Results 61 to 70 of about 13,695 (188)
Myeloid transformation by MLL - ENL depends strictly on C/EBP
Life Science Alliance, 2021 This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.
Radoslaw Wesolowski +7 more
doaj +1 more source
Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming
Advanced Materials, EarlyView.Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung +6 more
wiley +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, 2021 Objective. Ovarian cancer (OC) represents the most lethal gynecologic malignancy globally. Over the decades, lncRNAs have been considered as study focuses due to their genome-wide expression through multiple mechanisms in which regulation of target gene transcription through interaction with transcription factors or epigenetic proteins is proven.
Shuyan Yang +4 more
openaire +2 more sources
The Saudi Journal of GastroenterologyBackground: Cuproptosis is a novel pathway that differs from other forms of cell death and has been confirmed to be applicable for predicting tumor prognosis and clinical treatment response.
Tianchen Huang +8 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
Molecular mechanisms in the pathogenesis of classical Hodgkin lymphoma [PDF]
, 2015 Obwohl in den letzten Jahren bereits einige beteiligte Faktoren und Mechanismen der Pathogenese des klassischen Hodgkin-Lymphoms (cHL) aufgeklärt wurden, ist sie bis heute größenteils noch unbekannt.
Schneider, Markus
core
Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells [PDF]
, 2011 Despite the growing understanding of PDGF signaling, studies of PDGF function have encountered two major obstacles: the functional redundancy of PDGFRα and PDGFRβ in vitro and their distinct roles in vivo.
Berger, Bonnie +8 more
core +1 more source
Itraconazole inhibits tumor growth via
Cancer ScienceAbstractAdvanced colorectal cancer (CRC) is characterized by a high recurrence and metastasis rate, which is the primary cause of patient mortality. Unfortunately, effective anti‐cancer drugs for CRC are still lacking in clinical practice. We screened FDA‐approved drugs by utilizing targeted organoid sequencing data and found that the antifungal drug ...
Yong Zhang +6 more
openaire +2 more sources