Results 61 to 70 of about 10,537 (192)

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb

Biological Research
Abstract Background Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, has not been fully elucidated.
Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue, Xiaolong Liu   +9 more
openaire   +3 more sources

Correction: Corrigendum: Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB [PDF]

Nature, 2014
Corrigendum: Regulatory evolution through divergence of a phosphoswitch in the transcription factor ...
Vincent J. Lynch, Gemma May, Günter P. Wagner   +2 more
openaire   +1 more source

Integrated transcriptomic analysis reveals a CEBPB-DUSP1 axis driving tumor progression in colorectal cancer.

PLoS ONE
Colorectal cancer (CRC) is a prevalent and lethal malignancy, yet the transcriptional networks driving its progression remain incompletely defined. Here, we used integrated transcriptomic analyses of healthy and colorectal cancer samples from three ...
Huarong Zhou, Lili Fang
doaj   +1 more source

The distribution of the maximum values of signals in the positive and negative samples for CEBPB, CUX1, TCF, and CTCF.

, 2022
As we can see, the maximum values of signals in the positive and negative samples for CEBPB, CUX1, and TCF are difficult to distinguish while the ones for CTCF are easy to distinguish. (TIF)
Qinhu Zhang (12219347), Ying He (125930), Zhen Cui (2966148), De-Shuang Huang (396909), Zhanheng Chen (12219353), Zhenhao Guo (11724770), Qi Liu (33068), Siguo Wang (12219350)   +7 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis

Oncology Research, 2021
Abstract Background: Metastasis and paclitaxel (PTX) resistance are the main reason for the poor prognosis of ovarian cancer (OC). Evidence has shown that RNA-binding proteins (RBPs) and long noncoding RNAs (lncRNAs) can modulate post-transcriptional regulation.
WANG, HAN, ZHOU, YINGYING, ZHANG, SIYANG, QI, YA, WANG, MIN   +4 more
openaire   +2 more sources

Additional file 1 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

, 2022
Additional file 1: Figure S1. (A) GSE145608 revealed the expression profile of hsa_circRNA_002141 (circZDBF2) in oral cancer cell lines and human normal control cell line. (B) CircZDBF2 expression was silenced in SCC9 and SCC15 cells via the transfection
Bingyao Liu (6428873), Lei Zhu (16642), Juan Liu (6492), Yi Shuai (9176540), Bo Chen (32294), Ke Liu (121889), Maodian He (12336562), Junxia Li (136291), Lei Jin (120473), Xiaolei Shi (319891), Xinyao He (3109851), Liang Rong (3800992)   +11 more
core   +1 more source

CEBPB promotes ulcerative colitis-associated colorectal cancer by stimulating tumor growth and activating the NF-κB/STAT3 signaling pathway

Open Life Sciences
Ulcerative colitis-associated colorectal cancer (UCCRC) represents a significant complication of ulcerative colitis. CEBPB has been shown to promote the invasion of colon cancer cells.
Gao Shan, Wang Wei, Tong Xu-Dong, Wang Dao-Rong, Tian Ai-Xia, Yang Wei, Chen Jin-Min   +6 more
doaj   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source