Results 51 to 60 of about 10,537 (192)

CEBPB transkripsiyon faktörünün MN1 ekspresyonu üzerindeki etkisi

, 2022
Transkripsiyonel düzenleyici olarak rol oynayan yüksek MN1 gen ekspresyonunun in vivo fare modelinde myeloproliferatif hastalık (MPD) gelişimine, yüksek MN1 ekspresyonu birlikte CBFb-MYH11 varlığının ise akut miyeloid lösemi (AML) gelişimine neden olduğu
Sarıman, Melda, Abacı, Neslihan, Salman Yaylaz, Burcu, Emrence, Zeliha, Sırma Ekmekci, Sema   +4 more
core  

Deficiency of RARα Suppresses Decidualization via Downregulating CEBPB Transcription in Women With Recurrent Implantation Failure

Frontiers in Endocrinology, 2022
BackgroundRecurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and development.
Caiyi Huang, Caiyi Huang, Caiyi Huang, Caiyi Huang, Caiyi Huang, Qian Zhang, Qian Zhang, Qian Zhang, Tianxiang Ni, Tianxiang Ni, Tianxiang Ni, Tingting Zhou, Tingting Zhou, Tingting Zhou, Chunzi Lv, Chunzi Lv, Chunzi Lv, Yan Li, Yan Li, Yan Li, Junhao Yan, Junhao Yan, Junhao Yan, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen   +27 more
doaj   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Deletion of Cebpb has no effect on lung structure, but leads to aggregation of lymphoid cells in the lung.

, 2015
(A) Immunoblots of lung extracts from Cebpb+/+ or Cebpb-/- mice. Note that the predominant isoform expressed in mouse lungs is LAP and C/EBPβ expression in the lung is effectively lost in Cebpb-/- mice.
Ayako Hirata (701756), Mihoko Yamamoto (701760), Hideo Watanabe (701762), Kwok-Kin Wong (165223), Daniel B. Costa (701761), Sohei Nakayama (701757), Paul A. VanderLaan (701758), Elena Levantini (701759), Hideyo Hirai (247643), Susumu S. Kobayashi (701763), Yi Cai (233861)   +10 more
core   +1 more source

Additional file 7 of Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

, 2022
Additional file 7: Figure S7.
Yan Shu (441370), Chenxing Jian (12829267), Zhengyi Liu (838941), Wenzheng Yuan (838940), Zili Zhou (4452364), Shengbo Han (8078363), Haijun Bao (12829264), Ning Zhao (84707), Xiaogang Shu (838942)   +8 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids

PLoS ONE, 2023
Background Choledochal cysts (CC) are congenital bile duct anomalies with 6–30% risk for developing bile duct cancer. However, the molecular mechanisms underlying cancer risk of CC are unknown. We sought to identify the gene expression changes underlying
Yongqin Ye, Vincent Chi Hang Lui, Rosana Ottakandathil Babu, Zhongluan Wu, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Bin Wang, Paul Kwong Hang Tam   +8 more
doaj   +2 more sources

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Mechanism of circDYM/CEBPB/ZC3H4 axis in LPS-induced Microglial Apoptosis

, 2023
AbstractCircular RNAs (circRNAs) are a subtype of non-coding RNAs and contribute to the various central nervous system (CNS) diseases. However, microglia apoptosis which is regulated by circRNAs in major depressive disorder (MDD) is incompletely clear.
Zhongqiu Zhou, Qingqing Ye, Hui Ren, Li Yang, Yuan Zhang, Bing Han, Honghong Yao, Ying Bai   +7 more
openaire   +1 more source

Myeloid transformation by MLL - ENL depends strictly on C/EBP

Life Science Alliance, 2021
This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.
Radoslaw Wesolowski, Elisabeth Kowenz-Leutz, Karin Zimmermann, Dorothea Dörr, Maria Hofstätter, Robert K Slany, Alexander Mildner, Achim Leutz   +7 more
doaj   +1 more source