Results 51 to 60 of about 13,695 (188)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3 [PDF]

, 2016
The ubiquitin ligase MDM2 is best known for balancing the activity of the tumor suppressor p53. We have previously shown that MDM2 is vital for adipocyte conversion through controlling Cebpd expression in a p53-independent manner.
Barrio-Hernandez, I, Blagoev, B, Grøntved, L, Hallenborg, P, Kristiansen, K, Mandrup, S, Nielsen, R, Siersbæk, M   +7 more
core   +3 more sources

Transcription factor CEBPB inhibits the proliferation of osteosarcoma by regulating downstream target gene CLEC5A [PDF]

Journal of Clinical Laboratory Analysis, 2019
AbstractObjectiveTo screen the gene related to osteosarcoma (OS) metastasis and the molecular mechanism.MethodsGEO database and R2 chip analysis platform were used to screen genes related to OS metastasis. UCSC gene browser was used to find the transcription factor (TF) of CLEC5A. The mRNA level and protein expression of CLEC5A in OS tissues and normal
Jianhua Lu, Weikai Chen, Hao Liu, Huilin Yang, Tao Liu   +4 more
openaire   +2 more sources

Joint Analysis of CCAAT/Enhancer-Binding Protein Beta and Interleukin 1 Beta in the Treatment and Prognosis of Diffuse Large B-Cell Lymphoma

Frontiers in Bioscience-Landmark
Objective: The purpose of this study is to investigate the correlation between elevated levels of CCAAT/enhancer-binding protein beta (CEBPB) gene expression and unfavorable outcomes in diffuse large B-cell lymphoma (DLBCL).
Hongmin Wang, Shuo Zhang, Mengmeng Wang, Chaozhong Wang, Jihong Xu, Ming Jiang, Xue Han, Xiaotong Yang, Liping Zhang, Baotong Chen, Aichun Liu   +10 more
doaj   +1 more source

miR-155与CEBPB的靶向验证及繁殖性能相关基因的检测

野生动物学报, 2023
CEBPB具有调节黄体生成促进排卵的作用，对动物繁殖性能极为重要，试验旨在通过构建CEBPB的3'端非翻译区（3'UTR）双荧光素酶报告基因载体，验证MicroRNA-155（miR-155）调控CEBPB的分子机制。应用在线生物信息学软件预测miR-155与CEBPB基因3'UTR的靶向结合区，PCR扩增获取民猪组织基因组的CEBPB的3'UTR，将其插入psi-Check-2载体，构建野生型（wt-3'UTR）和突变型重组表达载体（mut-3'UTR），鉴定正确后，分别与miR-155模拟物 ...
李军义, 刘娣, 马红, 汪亮, 霍秀鹏, 郝丽   +5 more
doaj  

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb−/−Runx2+/− Murine Incisors

Scientific Reports, 2018
AbstractAdult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells. Thus, Cebpb acts upstream of Sox2 to regulate stemness.
Kazuyuki Saito, Katsu Takahashi, Boyen Huang, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Sayaka Mishima, Masaki Nagata, Machiko Iida, Yoshihito Tokita, Masato Asai, Akira Shimizu, Toshihisa Komori, Hidemitsu Harada, Mary MacDougall, Manabu Sugai, Kazuhisa Bessho   +17 more
openaire   +2 more sources

Unsupervised Bayesian linear unmixing of gene expression microarrays [PDF]

, 2013
Background: This paper introduces a new constrained model and the corresponding algorithm, called unsupervised Bayesian linear unmixing (uBLU), to identify biological signatures from high dimensional assays like gene expression microarrays. The basis for
A Hyvärinen, Aimee K Zaas, AK Zaas, Alfred O Hero III, B Chen, CM Carvalho, CP Robert, Cécile Bazot, D Dueck, DD Lee, EJ Fertig, Geoffrey S Ginsburg, GJ McLachlan, J Baek, J Paisley, Jean-Yves Tourneret, JM Nascimento, KY Yeung, M West, ME Winter, N Dobigeon, N Dobigeon, Nicolas Dobigeon, P Fogel, PJ Green, RO Duda, TD Moloshok, TF Cox, V Nikulin, WR Gilks, Y Huang   +30 more
core   +4 more sources

Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice [PDF]

Journal of Leukocyte Biology, 2017
Abstract Sepsis inflammation accelerates myeloid cell generation to compensate for rapid mobilization of the myeloid progenitors from bone marrow. This inflammation-driven myelopoiesis, however, generates myeloid progenitors with immunosuppressive functions that are unable to differentiate into mature, innate immune cells.
McPeak, Melissa B., Youssef, Dima, Williams, Danielle A., Pritchett, Christopher L., Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed   +6 more
openaire   +3 more sources

Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids

PLoS ONE, 2023
Background Choledochal cysts (CC) are congenital bile duct anomalies with 6–30% risk for developing bile duct cancer. However, the molecular mechanisms underlying cancer risk of CC are unknown. We sought to identify the gene expression changes underlying
Yongqin Ye, Vincent Chi Hang Lui, Rosana Ottakandathil Babu, Zhongluan Wu, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Bin Wang, Paul Kwong Hang Tam   +8 more
doaj   +2 more sources

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver [PDF]

, 2013
BACKGROUND: Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting ...
David J Steger, Diana Bernstein, John Lay, Klaus H Kaestner, Logan J Everett, Mitchell A Lazar, Sabina Lukovac   +6 more
core   +1 more source

Mechanism of circDYM/CEBPB/ZC3H4 axis in LPS-induced Microglial Apoptosis

, 2023
AbstractCircular RNAs (circRNAs) are a subtype of non-coding RNAs and contribute to the various central nervous system (CNS) diseases. However, microglia apoptosis which is regulated by circRNAs in major depressive disorder (MDD) is incompletely clear.
Zhongqiu Zhou, Qingqing Ye, Hui Ren, Li Yang, Yuan Zhang, Bing Han, Honghong Yao, Ying Bai   +7 more
openaire   +1 more source