Results 41 to 50 of about 13,695 (188)

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]

, 2014
BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W., Ferreira, Leonardo F., Judge, Andrew R., Judge, Sarah M., Kandarian, Susan C., Roberts, Brandon M., Wu, Chia-Ling   +6 more
core   +1 more source

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. [PDF]

, 2015
Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown.
Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Gallagher, Evan P, Hardiman, Gary, Lavado, Ramon, Maryoung, Lindley A, Schlenk, Daniel, Stapleton, Patricia L   +8 more
core   +1 more source

An integrative method to decode regulatory logics in gene transcription [PDF]

, 2017
Modeling of transcriptional regulatory networks (TRNs) has been increasingly used to dissect the nature of gene regulation. Inference of regulatory relationships among transcription factors (TFs) and genes, especially among multiple TFs, is still ...
Boheler, KR, Guan, D, He, B, Lu, A, Qin, J, Wang, C, Wang, JJ, Yan, B, Zhang, G, Zhu, H   +9 more
core   +2 more sources

Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes

iScience, 2023
Summary: DPP4 has been shown to induce diabetes-associated mitochondrial dysfunction and cognitive impairment through its non-canonical function. Here, we report that enhanced DPP4 expression in diabetes contributes to IP3R2-mediated mitochondria ...
Jiaxiu Li, Ya Hui, Zhiqiang Xu, Jie Tan, Kai Yin, Liuyu Kuang, Yunyun Tang, Junjie Wei, Qiongsui Zhong, Tianpeng Zheng   +9 more
doaj   +1 more source

miR-34a-/- mice are susceptible to diet-induced obesity [PDF]

, 2016
Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H., Caslake, Muriel, Collier, Andrew, Donnelly, Iona, Holmes, William, Kurowska-Stolarska, Mariola, Lavery, Christopher A., Miller, Ashley M.   +7 more
core   +1 more source

Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disease

Genes and Diseases, 2022
The damage of proximal tubular epithelial cells (PTECs) is considered a central event in the pathogenesis of chronic kidney disease (CKD) and deregulated repair processes of PTECs result in epithelial–mesenchymal transition (EMT), which in turn ...
Xin Yan, Rui Peng, Yilu Ni, Lei Chen, Qingling He, Qianyin Li, Qin Zhou   +6 more
doaj   +1 more source

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium [PDF]

, 2016
Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength.
Arking, D.E. (Dan), Arnold, A.M. (Alice M.), Atzmon, G. (Gil), Bennett, D.A. (David A.), Buchman, A.S. (Aron), Callisaya, M. (Michele), Chibinik, L.B. (Lori B.), Chou, W.-C. (Wen-Chi), Cummings, S., Davies, G. (Gail), Deary, I.J. (Ian), DeJager, P.L. (Philip L.), Eicher, J.D. (John D.), Evans, D.A. (Denis), Evans, D.S. (Daniel), Faul, J.D. (Jessica D.), Ferrucci, L. (Luigi), Garcia, M. (Melissa), Gillham-Nasenya, I. (Irina), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hofman, A. (Albert), Holtfreter, B. (Birte), Hsu, Y.-H. (Yi-Hsiang), Ittermann, T. (Till), Johnson, A.D. (Andrew), Karasik, D. (David), Kardia, S.L.R. (Sharon), Kiel, D.P. (Douglas P.), Kocher, T. (Thomas), Kritchevsky, S.B. (Stephen), Lahousse, L. (Lies), Liewald, D.C.M. (David), Liu, Y. (YongMei), Lohman, K. (Kurt), Lopez, L.M. (Lorna), Lunetta, K.L. (Kathryn), Mangino, M. (Massimo), Matteini, A.M. (Amy M.), Murabito, J. (Joanne), Newman, A.B. (Anne B.), Psaty, B.M. (Bruce), Rivadeneira Ramirez, F. (Fernando), Rotter, J.I. (Jerome I.), Seshadri, S. (Sudha), Siggeirsdottir, K. (Kristin), Smith, A.V. (Albert Vernon), Smith, J.A. (Jennifer A), Spector, T.D. (Timothy), Srikanth, V. (Velandai), Starr, J.M. (John), Tanaka, T. (Toshiko), Teumer, A. (Alexander), Thomson, R. (Russell), Tranah, G.J. (Gregory), Uitterlinden, A.G. (André), Völker, U. (Uwe), Völzke, H. (Henry), Walston, J. (Jeremy), Weir, D.R. (David), Windham, B.G. (Gwen), Yaffe, K., Yu, L. (Lei), Zhao, W. (Wei), Zhuang, W.V., Zillikens, M.C. (Carola), Zmuda, J. (Joseph)   +66 more
core   +1 more source

The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish

Aquaculture and Fisheries, 2023
Epiboly, the coordinated spreading of the enveloping layer (EVL), the yolk syncytial layer (YSL) and the deep cells (DCs) toward the vegetal pole, is required for gastrulation. Interference with the EVL leads to early developmental failure.
Xin Zhang, Zhichao Wu, Mengdi Bu, Ruiqin Hu, Xiaowen Zhang, Wenhao Li, Liangbiao Chen   +6 more
doaj   +1 more source

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]

, 2013
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D, Ford, Gregory D, Gates, Alicia S, Laplaca, Michelle C, Surles-Zeigler, Monique C, White, Todd E   +5 more
core   +2 more sources

RETRACTED ARTICLE: Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

Journal of Translational Medicine, 2022
Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored.
Zili Zhou, Yan Shu, Haijun Bao, Shengbo Han, Zhengyi Liu, Ning Zhao, Wenzheng Yuan, Chenxing Jian, Xiaogang Shu   +8 more
doaj   +1 more source