Results 21 to 30 of about 10,239 (195)

Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib

Melanoma Research, 2020
Introduction of targeted therapy in the treatment of metastatic cutaneous malignant melanoma (CMM) has improved clinical outcome during the last years. However, only in a subset of the CMM patients, this will lead to long-term effects. CEBPB is a transcription factor that has been implicated in various physiological and pathological processes ...
Vidarsdottir, Linda, Fernandes, Rita Valador, Zachariadis, Vasilios, Das, Ishani, Edsbacker, Elin, Sigvaldadottir, Ingibjorg, Azimi, Alireza, Hoiom, Veronica, Hansson, Johan, Grander, Dan, Egyhazi Brage, Suzanne, Pokrovskaja Tamm, Katja   +11 more
openaire   +4 more sources

Abnormal expression of CEBPB promotes the progression of renal cell carcinoma through regulating the generation of IL-6

Heliyon, 2023
Background: The CCAAT/enhancer-binding protein beta (CEBPB), a transcription factor regulating immune and inflammatory responses, has been implicated in the pathogenesis of various malignancies.
Yaoqiang Ren
exaly   +3 more sources

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb−/−Runx2+/− Murine Incisors [PDF]

Scientific Reports, 2018
AbstractAdult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells. Thus, Cebpb acts upstream of Sox2 to regulate stemness.
Kazuyuki Saito, Katsu Takahashi, Boyen Huang, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Sayaka Mishima, Masaki Nagata, Machiko Iida, Yoshihito Tokita, Masato Asai, Akira Shimizu, Toshihisa Komori, Hidemitsu Harada, Mary MacDougall, Manabu Sugai, Kazuhisa Bessho   +17 more
openaire   +3 more sources

Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD [PDF]

Molecular Cancer Research, 2020
Abstract The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival. As a potential therapeutic approach to exploit these findings, we created dominant-negative (DN) ATF5 forms lacking DNA ...
Sun, Xiaotian, Jefferson, Parvaneh, Zhou, Qing, Angelastro, James M, Greene, Lloyd A   +4 more
openaire   +6 more sources

Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise [PDF]

The Journal of Physiological Sciences, 2015
In mouse models, CCAAT enhancer-binding protein beta (CEBPB) is necessary for M2 macrophage-mediated regeneration after muscle injury. In humans, CEBPB expression in blood was strongly associated with muscle strength. In this study we aimed to test whether CEBPB expression in blood in people is increased 2 days after exercise designed to induce muscle ...
Blackwell, James R., Harries, LW, Pilling, LC, Ferrucci, L, Jones, Andrew M., Melzer, D   +5 more
openaire   +5 more sources

Transcriptional Regulation of Autophagy Genes via Stage-Specific Activation of CEBPB and PPARG during Adipogenesis: A Systematic Study Using Public Gene Expression and Transcription Factor Binding Datasets

Cells, 2019
Autophagy is the cell self-eating mechanism to maintain cell homeostasis by removing damaged intracellular proteins or organelles. It has also been implicated in the development and differentiation of various cell types including the adipocyte.
Jinseok Hwang, Deok Ryong Kim, Mahmoud Ahmed   +2 more
exaly   +3 more sources

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer [PDF]

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +2 more sources

Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization

Cell Reports, 2023
Summary: Macroautophagy/autophagy plays a pivotal role in immune regulation. Its significance is evident in modulation of immune cell differentiation and maturation, physiologically and pathologically.
Yongcheng Zhu
exaly   +3 more sources

CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming. [PDF]

Theranostics
RATIONALE: Triple negative breast cancer (TNBC) poorly responds to immune checkpoint blockade (ICB) therapy. Dormant tumor cells are recognized as immunotherapy-resistant reservoirs that may lead to tumor relapse, although the underlying mechanisms ...
Bai J, Su H, Wang S, Dong Y, Gao Y.
europepmc   +2 more sources

CEBPB dampens the cuproptosis sensitivity of colorectal cancer cells by facilitating the PI3K/AKT/mTOR signaling pathway

The Saudi Journal of Gastroenterology
Background: Cuproptosis is a novel pathway that differs from other forms of cell death and has been confirmed to be applicable for predicting tumor prognosis and clinical treatment response.
Tianchen Huang, Yong Zhang, Yachao Wu, Xiaodong Han, Lei Li, Zhipeng Guo, Kan Li, Yanshan Xin, Weijie Wang   +8 more
doaj   +2 more sources