Results 21 to 30 of about 13,695 (188)

MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice [PDF]

, 2013
Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver.
A Grefhorst, A Kauffmann, AC Calkin, AM Lakner, Ashley M. Miller, B Wang, BS Carvalho, Carlos Fernández-Hernando, Christopher A. Lavery, CL Chang, CP Day, Cristina M. Ramirez, Derek S. Gilchrist, E Lima-Cabello, Elisa Araldi, Iain B. McInnes, IP Pogribny, J Stanczyk, J Zhou, Jagtar Nijjar, JC Cohen, L Salmena, M He, M Kurowska-Stolarska, M Nazari-Jahantigh, M Skarn, Mariola Kurowska-Stolarska, Massimo Federici, MM Donners, N Ghouri, N Kloting, R Breitling, R Sanges, RC Gentleman, RM O’Connell, RS Huang, RX Leng, S Bala, S Bala, T Chen, W Filipowicz, W Huang, ZB Han   +42 more
core   +16 more sources

A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies [PDF]

Brain, 2021
Abstract Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease pathogenesis remains incompletely ...
Yinan Yao, Seong Su Kang, Yiyuan Xia, Zhi-Hao Wang, Xia Liu, Thorsten Muller, Yi E Sun, Keqiang Ye   +7 more
openaire   +2 more sources

Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury [PDF]

PeerJ, 2021
Background Renal ischemia-reperfusion injury (IRI) is a disease with high incidence rate in kidney related surgery. Micro RNA (miRNA) and transcription factors (TFs) are widely involved in the process of renal IRI through regulation of their target genes.
Peng Ke, Lin Qian, Yi Zhou, Liu Feng, Zhentao Zhang, Chengjie Zheng, Mengnan Chen, Xinlei Huang, Xiaodan Wu   +8 more
doaj   +2 more sources

Prospective signs of cleidocranial dysplasia in Cebpb deficiency [PDF]

Journal of Biomedical Science, 2014
Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of
Huang, Boyen, Takahashi, Katsu, Jennings, Ernest, Pumtang-on, Pongthorn, Kiso, Honoka, Togo, Yumiko, Saito, Kazuyuki, Sugai, Manabu, Akira, Shizuo, Shimizu, Akira, Bessho, Kazuhisa   +10 more
openaire   +3 more sources

Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice [PDF]

Biochemical and Biophysical Research Communications, 2015
The CCAAT/enhancer-binding protein β (C/EBPβ) transcription factor is required for granulopoiesis under stress conditions. However, little is known about its roles in steady state hematopoiesis. Here, we analyzed the peripheral blood and bone marrow of Cebpb(-/-) mice at steady state by flow cytometry and unexpectedly found that the number of ...
Akihiro, Tamura, Hideyo, Hirai, Asumi, Yokota, Atsushi, Sato, Tsukimi, Shoji, Takahiro, Kashiwagi, Masaki, Iwasa, Aya, Fujishiro, Yasuo, Miura, Taira, Maekawa   +9 more
openaire   +2 more sources

A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]

, 2020
Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J, Binder, Elisabeth B, Carrillo-Roa, Tania, Cattaneo, Annamaria, DeModena, Anna, Henigsberg, Neven, Kelsoe, John R, Leckband, Susan G, Liu, Jia Jia, McCarthy, Michael, Mors, Ole, Ren, Hongyan, Rietschel, Marcella, Shekhtman, Tatyana, Wei, Ya Bin   +14 more
core   +2 more sources

Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib

Melanoma Research, 2020
Introduction of targeted therapy in the treatment of metastatic cutaneous malignant melanoma (CMM) has improved clinical outcome during the last years. However, only in a subset of the CMM patients, this will lead to long-term effects. CEBPB is a transcription factor that has been implicated in various physiological and pathological processes ...
Vidarsdottir, Linda, Fernandes, Rita Valador, Zachariadis, Vasilios, Das, Ishani, Edsbäcker, Elin, Sigvaldadottir, Ingibjorg, Azimi, Alireza, Höiom, Veronica, Hansson, Johan, Grandér, Dan, Egyházi Brage, Suzanne, Pokrovskaja Tamm, Katja   +11 more
openaire   +3 more sources

Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice

Cellular & Molecular Biology Letters, 2023
Background Lupus nephritis (LN) is associated with significant mortality and morbidity, while effective therapeutics and biomarkers are limited since the pathogenesis is complex. This study investigated the roles of the CEBPB/BZW1/eIF2α axis in metabolic
Huimeng Qi, Zhaoguo Zheng, Qiang Liu
doaj   +1 more source

Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. [PDF]

PLoS Genetics, 2013
Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the
Caterina Clementi, Swamy K Tripurani, Michael J Large, Mark A Edson, Chad J Creighton, Shannon M Hawkins, Ertug Kovanci, Vesa Kaartinen, John P Lydon, Stephanie A Pangas, Francesco J DeMayo, Martin M Matzuk   +11 more
doaj   +1 more source

Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD

Molecular Cancer Research, 2020
Abstract The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival. As a potential therapeutic approach to exploit these findings, we created dominant-negative (DN) ATF5 forms lacking DNA ...
Sun, Xiaotian, Jefferson, Parvaneh, Zhou, Qing, Angelastro, James M, Greene, Lloyd A   +4 more
openaire   +5 more sources