Results 31 to 40 of about 10,239 (195)

Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.

PLoS ONE, 2018
Triple negative breast cancers (TNBCs) are known to express low PGR, ESR1, and ERBB2, and high KRT5, KRT14, and KRT17. However, the reasons behind the increased expressions of KRT5, KRT14, KRT17 and decreased expressions of PGR, ESR1, and ERBB2 in TNBCs ...
Goodwin G Jinesh, Elsa R Flores, Andrew S Brohl   +2 more
doaj   +2 more sources

Epigenetically-controlled CEBPB regulates kidney cancer tumorigenesis via GPD1L-mediated ether lipid synthesis [PDF]

Cell Death and Disease
Clear cell renal cell carcinoma (ccRCC) is characterized by disrupted lipid metabolism, traditionally attributed to VHL mutations and HIF stabilization.
Thi Ha Nguyen, Xuan Linh Mai, Tin Tin Manh Nguyen, Hoonsik Nam, Sunghyouk Park, Ji Yun Lee   +5 more
doaj   +2 more sources

Deficiency of RARα Suppresses Decidualization via Downregulating CEBPB Transcription in Women With Recurrent Implantation Failure

Frontiers in Endocrinology, 2022
BackgroundRecurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and development.
Caiyi Huang, Caiyi Huang, Caiyi Huang, Caiyi Huang, Caiyi Huang, Qian Zhang, Qian Zhang, Qian Zhang, Tianxiang Ni, Tianxiang Ni, Tianxiang Ni, Tingting Zhou, Tingting Zhou, Tingting Zhou, Chunzi Lv, Chunzi Lv, Chunzi Lv, Yan Li, Yan Li, Yan Li, Junhao Yan, Junhao Yan, Junhao Yan, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen   +27 more
doaj   +3 more sources

Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb

Biological Research
Abstract Background Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, has not been fully elucidated.
Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue, Xiaolong Liu   +9 more
openaire   +4 more sources

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner [PDF]

Animals
N6-methyladenosine (m6A), a predominant and reversible modification of mammalian RNA, plays a critical role in regulating growth, development, and metabolism.
Hongyun Jiao, Lu Zhu, Xinyu Tang, Ping Gong, Wei Wang, Baolong Liu, Jun Luo   +6 more
doaj   +2 more sources

Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise [PDF]

, 2014
In mouse models, CCAAT enhancer-binding protein beta (CEBPB) is necessary for M2 macrophage-mediated regeneration after muscle injury. In humans, CEBPB expression in blood was strongly associated with muscle strength.
LW Harries (21821876), James R. Blackwell (21825578), Andrew M. Jones (3826150), LC Pilling (21821873), D Melzer (14728009), L Ferrucci (682240)   +5 more
core   +6 more sources

CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling

Cell Death Discovery
Colorectal cancer (CRC) is a highly malignant carcinoma associated with poor prognosis, and metastasis is one of the most common causes of death in CRC. Serpin Family A Member 1 (SERPINA1) is a serine protease inhibitor from the Serpin family.
Yiming Ma, Ying Chen, Lei Zhan, Qian Dong, Yuanhe Wang, Xiaoyan Li, Lian He, Jingdong Zhang   +7 more
doaj   +3 more sources

Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury [PDF]

PeerJ, 2021
Background Renal ischemia-reperfusion injury (IRI) is a disease with high incidence rate in kidney related surgery. Micro RNA (miRNA) and transcription factors (TFs) are widely involved in the process of renal IRI through regulation of their target genes.
Peng Ke, Lin Qian, Yi Zhou, Liu Feng, Zhentao Zhang, Chengjie Zheng, Mengnan Chen, Xinlei Huang, Xiaodan Wu   +8 more
doaj   +2 more sources

Integrated bioinformatic identification and translational validation of key biomarkers and therapeutic candidates for preeclampsia-related acute kidney injury [PDF]

Archives of Gynecology and Obstetrics
Objective This study aimed to identify and validate key biomarkers for PE-AKI and to explore potential therapeutic candidates through an integrated bioinformatic and experimental approach.
Lina Gao, Dong Yan, Xiaohui Liu, De Chen, Xiaoling Liu, Jian Liu   +5 more
doaj   +2 more sources

A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies [PDF]

Brain, 2021
Abstract Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease pathogenesis remains incompletely ...
Yinan Yao, Seong Su Kang, Yiyuan Xia, Zhi-Hao Wang, Xia Liu, Thorsten Muller, Yi E Sun, Keqiang Ye   +7 more
openaire   +2 more sources