Results 31 to 40 of about 10,537 (192)
A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies [PDF]
Brain, 2021 Abstract Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease pathogenesis remains incompletely ...
Yinan Yao +7 more
openaire +2 more sources
Cellular & Molecular Biology Letters, 2023 Background Lupus nephritis (LN) is associated with significant mortality and morbidity, while effective therapeutics and biomarkers are limited since the pathogenesis is complex. This study investigated the roles of the CEBPB/BZW1/eIF2α axis in metabolic
Huimeng Qi, Zhaoguo Zheng, Qiang Liu
doaj +1 more source
CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming. [PDF]
TheranosticsRATIONALE: Triple negative breast cancer (TNBC) poorly responds to immune checkpoint blockade (ICB) therapy. Dormant tumor cells are recognized as immunotherapy-resistant reservoirs that may lead to tumor relapse, although the underlying mechanisms ...
Bai J, Su H, Wang S, Dong Y, Gao Y.
europepmc +2 more sources
Cells, 2019 Autophagy is the cell self-eating mechanism to maintain cell homeostasis by removing damaged intracellular proteins or organelles. It has also been implicated in the development and differentiation of various cell types including the adipocyte.
Mahmoud Ahmed +5 more
doaj +1 more source
Cancer Cell International, 2022 Highlights EIF3B is a prognostic biomarker for HNSCC risk; EIF3B promotes HNSCC progression in vitro and in vivo; EIF3B promotes CEBPB translation and activates the MAPK pathway; IL6R and CCNG2 are targets of EIF3B-regulated CEBPB translation.
Chengzhi Xu +4 more
doaj +1 more source
Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. [PDF]
PLoS Genetics, 2013 Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the
Caterina Clementi +11 more
doaj +1 more source
New control of the senescence barrier in breast cancer
Molecular & Cellular Oncology, 2020 Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier.
Tânia D. F. Costa, Staffan Strömblad
doaj +1 more source
t(14;20)(q32;q13) IgH/CEBPB [PDF]
, 2009 Review on t(14;20)(q32;q13) IgH/CEBPB, with data on clinics, and the genes ...
Huret, JL
core +1 more source
Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise [PDF]
The Journal of Physiological Sciences, 2015 In mouse models, CCAAT enhancer-binding protein beta (CEBPB) is necessary for M2 macrophage-mediated regeneration after muscle injury. In humans, CEBPB expression in blood was strongly associated with muscle strength. In this study we aimed to test whether CEBPB expression in blood in people is increased 2 days after exercise designed to induce muscle ...
Blackwell, James R. +5 more
openaire +3 more sources
JHEP Reports, 2023 Background & Aims: Liver regeneration is vital for the recovery of liver function after injury, yet the underlying mechanism remains to be elucidated.
Guoqiang Li +22 more
doaj +1 more source