Results 11 to 20 of about 10,239 (195)

Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling

Mediators of Inflammation, 2022
Systemic lupus erythematosus (SLE) is an autoimmune disease leading to inflammatory damage in multiple target organs, and lupus nephritis (LN) is one of the most life-threatening organ manifestations.
Xiaoyang Wang, Weili Cheng, Xiaopan Chen, Yanan Gong, Guangjie Wang, Xiaoxue Zhang, Yuanyuan Qi   +6 more
doaj   +4 more sources

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways

Frontiers in Pharmacology, 2022
The super-enhancer, a cluster of enhancers with strong transcriptional activity, has become one of the most interesting topics in recent years. This study aimed to investigate pathogenic super-enhancer–driven genes in IBD and screen therapeutic drugs ...
Hailong Cao, Honggang Zhou
exaly   +5 more sources

CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer

BMC Cancer
Background As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease management.
Jiahong Tan, Lin Zhao, Daoqi Wang, Xiaodie Wu, Yongxiang Bi, Hanying Wang, Na Ma, Dehong Yang, Wei Dong, Jie Zhang   +9 more
doaj   +4 more sources

Mendelian Randomization and Transcriptome Analyses Reveal Important Roles for CEBPB and CX3CR1 in Osteoarthritis

Bioengineering
Background: Chemokines play a pivotal role in the progression of osteoarthritis (OA), but their exact mechanisms remain unclear. This study aimed to identify potential chemokine-associated biomarkers and investigate their causal relationships with OA ...
Hui Gao, Xinling Gan, Jing He, Chengqi He   +3 more
doaj   +5 more sources

CEBPB Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via CTLA4 Up-regulation in T Cells [PDF]

Cancer Communications
Background: Immune checkpoint inhibitors are ineffective in the majority of colorectal cancers (CRCs) that are microsatellite stable. However, the underlying reasons for their unresponsiveness and mechanisms of immune evasion are poorly understood.
Hye Jeong Yun, Chan Ho Park, Dahye Yun, Hye-Ri Shin, Jeong Dong Lee, Changhee Park, Kiyeon Kim, Heejun Shim, Hyejin Sim, Se Min Kim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Yoojoo Lim, Seung-Yong Jeong, Kyu Joo Park, Tae-You Kim, Junil Kim, Jae-Kyung Won, Sae-Won Han   +19 more
doaj   +3 more sources

CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer [PDF]

Cancer Communications
Background: Liver metastasis represents the most common distant dissemination in gastric cancer (GC) but persists as a challenging condition to manage, and its driving molecular mechanisms remain poorly understood.
Zhixiang Zuo, Jiaqi Liang, Li-Na He, Kai Xu, Muren Hu, Kunming Zhang, Wei Gao, Junyi Yin, Lanlin Zhang, Boning Ma, Zhiqian Hu, Pengfei Zhang, Hong Jiang   +12 more
doaj   +5 more sources

CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma

Frontiers in Immunology, 2022
Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients ...
Jingrun Yang, Jingrun Yang, Yang Xu, Kuixia Xie, Ling Gao, Wenying Zhong, Xinhua Liu, Xinhua Liu   +7 more
exaly   +5 more sources

CEBPB as a prognostic biomarker and its association with immune cells in clear cell renal cell carcinoma

Biochemistry and Biophysics Reports
Clear cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy with a poor prognosis. This study examines the expression, prognostic significance, and immune association of CCAAT/enhancer-binding protein beta (CEBPB) in ccRCC.
Yaoqiang Ren, Min Wei, Quanfa Tian, Wenke Guo   +3 more
doaj   +4 more sources

Doxorubicin induces ferroptosis in endometrial cancer by suppressing the MKK6/p38/CEBPB axis [PDF]

Journal of Translational Medicine
Background Doxorubicin is a cornerstone chemotherapeutic agent. However, its role in ferroptosis and the underlying molecular mechanisms in endometrial cancer (EC) remain inadequately explored.
Jingyan Zhang, Zhenhui Wang, Yanfang Li, Panpan Zhao, Dan Ren, Xiaoqin Lu   +5 more
doaj   +4 more sources

Prospective signs of cleidocranial dysplasia in Cebpb deficiency [PDF]

Journal of Biomedical Science, 2014
Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of
Huang, Boyen, Takahashi, Katsu, Jennings, Ernest, Pumtang-on, Pongthorn, Kiso, Honoka, Togo, Yumiko, Saito, Kazuyuki, Sugai, Manabu, Akira, Shizuo, Shimizu, Akira, Bessho, Kazuhisa   +10 more
openaire   +5 more sources