Results 11 to 20 of about 10,537 (192)

Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling

Mediators of Inflammation, 2022
Systemic lupus erythematosus (SLE) is an autoimmune disease leading to inflammatory damage in multiple target organs, and lupus nephritis (LN) is one of the most life-threatening organ manifestations.
Xiaoyang Wang, Weili Cheng, Xiaopan Chen, Yanan Gong, Guangjie Wang, Xiaoxue Zhang, Yuanyuan Qi   +6 more
doaj   +4 more sources

CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer

BMC Cancer
Background As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease management.
Jiahong Tan, Lin Zhao, Daoqi Wang, Xiaodie Wu, Yongxiang Bi, Hanying Wang, Na Ma, Dehong Yang, Wei Dong, Jie Zhang   +9 more
doaj   +4 more sources

Mendelian Randomization and Transcriptome Analyses Reveal Important Roles for CEBPB and CX3CR1 in Osteoarthritis

Bioengineering
Background: Chemokines play a pivotal role in the progression of osteoarthritis (OA), but their exact mechanisms remain unclear. This study aimed to identify potential chemokine-associated biomarkers and investigate their causal relationships with OA ...
Hui Gao, Xinling Gan, Jing He, Chengqi He   +3 more
doaj   +5 more sources

Doxorubicin induces ferroptosis in endometrial cancer by suppressing the MKK6/p38/CEBPB axis [PDF]

Journal of Translational Medicine
Background Doxorubicin is a cornerstone chemotherapeutic agent. However, its role in ferroptosis and the underlying molecular mechanisms in endometrial cancer (EC) remain inadequately explored.
Jingyan Zhang, Zhenhui Wang, Yanfang Li, Panpan Zhao, Dan Ren, Xiaoqin Lu   +5 more
doaj   +4 more sources

Prospective signs of cleidocranial dysplasia in Cebpb deficiency [PDF]

Journal of Biomedical Science, 2014
Background: Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations.
Jennings, EA, Sugai, Manabu, Manabu Sugai, Yumiko Togo, Pongthorn Pumtang-on, Ernest A Jennings, Pumtang-on, Pongthorn, Bessho, Kazuhisa, Takahashi, K, Pumtang-On, P, Togo, Y, Akira, S, Saito, Kazuyuki, Togo, Yumiko, Takahashi, Katsu, Shimizu, A, Bessho, K, Kazuhisa Bessho, Kiso, H, Huang, Boyen, Saito, K, Kiso, Honoka, Honoka Kiso, Sugai, M, Akira Shimizu, Kazuyuki Saito, Huang, B, Jennings, Ernest, Boyen Huang, Shizuo Akira, Shimizu, Akira, Katsu Takahashi, Akira, Shizuo   +32 more
core   +5 more sources

Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib

Melanoma Research, 2020
Introduction of targeted therapy in the treatment of metastatic cutaneous malignant melanoma (CMM) has improved clinical outcome during the last years. However, only in a subset of the CMM patients, this will lead to long-term effects.
Grander, Dan, Fernandes, Rita Valador, Pokrovskaja Tamm, Katja, Zachariadis, Vasilios, Edsbacker, Elin, Das, Ishani, Sigvaldadottir, Ingibjorg, Azimi, Alireza, Hoiom, Veronica, Vidarsdottir, Linda, Hansson, Johan, Egyhazi Brage, Suzanne   +11 more
core   +4 more sources

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb⁻/⁻Runx2⁺/⁻ Murine Incisors [PDF]

Scientific Reports, 2018
Adult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells.
Mary MacDougall, Asai, Masato, Sugai, Manabu, Manabu Sugai, Asahara, Masakazu, Yumiko Togo, Bessho, Kazuhisa, Nagata, Masaki, Toshihisa Komori, Komori, Toshihisa, Saito, Kazuyuki, Togo, Yumiko, Takahashi, Katsu, Sayaka Mishima, MacDougall, Mary, Kazuhisa Bessho, Huang, Boyen, Hidemitsu Harada, Harada, Hidemitsu, Kiso, Honoka, Tsukamoto, Hiroko, Mishima, Sayaka, Honoka Kiso, Yoshihito Tokita, Akira Shimizu, Hiroko Tsukamoto, Kazuyuki Saito, Boyen Huang, Masato Asai, Masakazu Asahara, Iida, Machiko, Shimizu, Akira, Katsu Takahashi, Machiko Iida, Masaki Nagata, Tokita, Yoshihito   +35 more
core   +3 more sources

Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/β-Catenin Pathway

Stem Cells International, 2022
Fracture is the most common traumatic organ injury, and fracture nonunion is a critical clinical challenge. The research on the mechanisms of skeletal stem cell (SSC) differentiation and fracture healing may help develop new treatment strategies and ...
Jiansong Wang, Chensong Yang, Fanyu Kong, Zhi Zhang, Shengchao Ji, Guixin Sun   +5 more
doaj   +2 more sources

miR-155与CEBPB的靶向验证及繁殖性能相关基因的检测

野生动物学报, 2023
CEBPB具有调节黄体生成促进排卵的作用，对动物繁殖性能极为重要，试验旨在通过构建CEBPB的3'端非翻译区（3'UTR）双荧光素酶报告基因载体，验证MicroRNA-155（miR-155）调控CEBPB的分子机制。应用在线生物信息学软件预测miR-155与CEBPB基因3'UTR的靶向结合区，PCR扩增获取民猪组织基因组的CEBPB的3'UTR，将其插入psi-Check-2载体，构建野生型（wt-3'UTR）和突变型重组表达载体（mut-3'UTR），鉴定正确后，分别与miR-155模拟物 ...
李军义, 刘娣, 马红, 汪亮, 霍秀鹏, 郝丽   +5 more
doaj   +2 more sources

Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD [PDF]

Molecular Cancer Research, 2020
The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival.
Zhou, Qing, Greene, Lloyd A, Jefferson, Parvaneh, Angelastro, James M, Sun, Xiaotian   +4 more
core   +6 more sources