Results 1 to 10 of about 10,537 (192)

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways

Frontiers in Pharmacology, 2022
The super-enhancer, a cluster of enhancers with strong transcriptional activity, has become one of the most interesting topics in recent years. This study aimed to investigate pathogenic super-enhancer–driven genes in IBD and screen therapeutic drugs ...
Xiaoting Gu, Jinhe Li, Yayue Hu
exaly   +5 more sources

CEBPB Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via CTLA4 Up-regulation in T Cells [PDF]

Cancer Communications
Background: Immune checkpoint inhibitors are ineffective in the majority of colorectal cancers (CRCs) that are microsatellite stable. However, the underlying reasons for their unresponsiveness and mechanisms of immune evasion are poorly understood.
Hye Jeong Yun, Chan Ho Park, Dahye Yun, Hye-Ri Shin, Jeong Dong Lee, Changhee Park, Kiyeon Kim, Heejun Shim, Hyejin Sim, Se Min Kim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Yoojoo Lim, Seung-Yong Jeong, Kyu Joo Park, Tae-You Kim, Junil Kim, Jae-Kyung Won, Sae-Won Han   +19 more
doaj   +3 more sources

CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer [PDF]

Cancer Communications
Background: Liver metastasis represents the most common distant dissemination in gastric cancer (GC) but persists as a challenging condition to manage, and its driving molecular mechanisms remain poorly understood.
Zhixiang Zuo, Jiaqi Liang, Li-Na He, Kai Xu, Muren Hu, Kunming Zhang, Wei Gao, Junyi Yin, Lanlin Zhang, Boning Ma, Zhiqian Hu, Pengfei Zhang, Hong Jiang   +12 more
doaj   +5 more sources

CEBPB as a Prognostic Biomarker and Its Association With Immune Cells in Clear Cell Renal Cell Carcinoma

Biochemistry and Biophysics Reports
Clear cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy with a poor prognosis. This study examines the expression, prognostic significance, and immune association of CCAAT/enhancer-binding protein beta (CEBPB) in ccRCC.
Yaoqiang Ren
exaly   +4 more sources

Abnormal Expression of CEBPB Promotes the Progression of Renal Cell Carcinoma Through Regulating the Generation of IL-6

Heliyon, 2023
Background: The CCAAT/enhancer-binding protein beta (CEBPB), a transcription factor regulating immune and inflammatory responses, has been implicated in the pathogenesis of various malignancies.
Yaoqiang Ren
exaly   +3 more sources

Molecular Signatures of HIV-Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV. [PDF]

Adv Sci (Weinh)
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Chennakesavan K, Samikkannu M, Gupta S, Tayo OI, Acharya A, Cai JJ, Byrareddy SN, Samikkannu T.   +7 more
europepmc   +2 more sources

Curcumin alleviates metabolic dysfunction-associated steatotic liver disease via gut microbiota-dependent epigenetic alterations [PDF]

Molecular Biomedicine
Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent, yet effective therapies remain limited. Curcumin (Cur), a polyphenol with well-documented metabolic benefits, shows therapeutic promise in MASLD, but its efficacy
Yong Zhu, Jinhu Ma, Danhong Wang, Mingzhu Cui, Jin Peng, Xuejin Lu, Xingyue Pei, Yi Wang, Jing Lv, Yuxuan Yan, Wenhao Ma, Mingtao Zhao, Shulei You, Jie Ma, Yunshu Tang, Yaling Zhu   +15 more
doaj   +2 more sources

Macrophage Autophagy Deficiency-Induced CEBPB Accumulation Alleviates Atopic Dermatitis via Impairing M2 Polarization

Cell Reports, 2023
Summary: Macroautophagy/autophagy plays a pivotal role in immune regulation. Its significance is evident in modulation of immune cell differentiation and maturation, physiologically and pathologically.
Yongcheng Zhu, Yunyao Liu, Yuxiang Ma, Liu Chen, He Huang, Siting Huang, Huiling Zhang, Yuying He, Cheng Tan, Yuan He, Lei Qiang   +10 more
exaly   +3 more sources

CEBPB Is Associated With Active Tumor Immune Environment and Favorable Prognosis of Metastatic Skin Cutaneous Melanoma

Frontiers in Immunology, 2022
Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients ...
Xinhua Liu
exaly   +3 more sources

Epigenetically-controlled CEBPB regulates kidney cancer tumorigenesis via GPD1L-mediated ether lipid synthesis [PDF]

Cell Death and Disease
Clear cell renal cell carcinoma (ccRCC) is characterized by disrupted lipid metabolism, traditionally attributed to VHL mutations and HIF stabilization.
Thi Ha Nguyen, Xuan Linh Mai, Tin Tin Manh Nguyen, Hoonsik Nam, Sunghyouk Park, Ji Yun Lee   +5 more
doaj   +2 more sources