Results 1 to 10 of about 10,239 (195)

Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/β-Catenin Pathway

Stem Cells International, 2022
Fracture is the most common traumatic organ injury, and fracture nonunion is a critical clinical challenge. The research on the mechanisms of skeletal stem cell (SSC) differentiation and fracture healing may help develop new treatment strategies and ...
Jiansong Wang, Chensong Yang, Fanyu Kong, Zhi Zhang, Shengchao Ji, Guixin Sun   +5 more
doaj   +2 more sources

miR-155与CEBPB的靶向验证及繁殖性能相关基因的检测

野生动物学报, 2023
CEBPB具有调节黄体生成促进排卵的作用，对动物繁殖性能极为重要，试验旨在通过构建CEBPB的3'端非翻译区（3'UTR）双荧光素酶报告基因载体，验证MicroRNA-155（miR-155）调控CEBPB的分子机制。应用在线生物信息学软件预测miR-155与CEBPB基因3'UTR的靶向结合区，PCR扩增获取民猪组织基因组的CEBPB的3'UTR，将其插入psi-Check-2载体，构建野生型（wt-3'UTR）和突变型重组表达载体（mut-3'UTR），鉴定正确后，分别与miR-155模拟物 ...
李军义, 刘娣, 马红, 汪亮, 霍秀鹏, 郝丽   +5 more
doaj   +2 more sources

New control of the senescence barrier in breast cancer

Molecular & Cellular Oncology, 2020
Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier.
Tânia D. F. Costa, Staffan Strömblad
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Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration

JHEP Reports, 2023
Background & Aims: Liver regeneration is vital for the recovery of liver function after injury, yet the underlying mechanism remains to be elucidated.
Guoqiang Li, Lijun Zhu, Mingwei Guo, Dongmei Wang, Meiyao Meng, Yinzhao Zhong, Zhijian Zhang, Yi Lin, Caizhi Liu, Jiawen Wang, Yahui Zhang, Yining Gao, Yuxiang Cao, Zhirui Xia, Jin Qiu, Yu Li, Shuang Liu, Haibing Chen, Wenyue Liu, Yu Han, Minghua Zheng, Xinran Ma, Lingyan Xu   +22 more
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CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma. [PDF]

PLoS ONE, 2015
Lung cancer is the leading cause of cancer death worldwide. Although disruption of normal proliferation and differentiation is a vital component of tumorigenesis, the mechanisms of this process in lung cancer are still unclear.
Yi Cai, Ayako Hirata, Sohei Nakayama, Paul A VanderLaan, Elena Levantini, Mihoko Yamamoto, Hideyo Hirai, Kwok-Kin Wong, Daniel B Costa, Hideo Watanabe, Susumu S Kobayashi   +10 more
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Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes

iScience, 2023
Summary: DPP4 has been shown to induce diabetes-associated mitochondrial dysfunction and cognitive impairment through its non-canonical function. Here, we report that enhanced DPP4 expression in diabetes contributes to IP3R2-mediated mitochondria ...
Jiaxiu Li, Ya Hui, Zhiqiang Xu, Jie Tan, Kai Yin, Liuyu Kuang, Yunyun Tang, Junjie Wei, Qiongsui Zhong, Tianpeng Zheng   +9 more
doaj   +1 more source

Tetratricopeptide repeat domain 36 deficiency mitigates renal tubular injury by inhibiting TGF-β1-induced epithelial–mesenchymal transition in a mouse model of chronic kidney disease

Genes and Diseases, 2022
The damage of proximal tubular epithelial cells (PTECs) is considered a central event in the pathogenesis of chronic kidney disease (CKD) and deregulated repair processes of PTECs result in epithelial–mesenchymal transition (EMT), which in turn ...
Xin Yan, Rui Peng, Yilu Ni, Lei Chen, Qingling He, Qianyin Li, Qin Zhou   +6 more
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The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish

Aquaculture and Fisheries, 2023
Epiboly, the coordinated spreading of the enveloping layer (EVL), the yolk syncytial layer (YSL) and the deep cells (DCs) toward the vegetal pole, is required for gastrulation. Interference with the EVL leads to early developmental failure.
Xin Zhang, Zhichao Wu, Mengdi Bu, Ruiqin Hu, Xiaowen Zhang, Wenhao Li, Liangbiao Chen   +6 more
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RETRACTED ARTICLE: Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

Journal of Translational Medicine, 2022
Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored.
Zili Zhou, Yan Shu, Haijun Bao, Shengbo Han, Zhengyi Liu, Ning Zhao, Wenzheng Yuan, Chenxing Jian, Xiaogang Shu   +8 more
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Joint Analysis of CCAAT/Enhancer-Binding Protein Beta and Interleukin 1 Beta in the Treatment and Prognosis of Diffuse Large B-Cell Lymphoma

Frontiers in Bioscience-Landmark
Objective: The purpose of this study is to investigate the correlation between elevated levels of CCAAT/enhancer-binding protein beta (CEBPB) gene expression and unfavorable outcomes in diffuse large B-cell lymphoma (DLBCL).
Hongmin Wang, Shuo Zhang, Mengmeng Wang, Chaozhong Wang, Jihong Xu, Ming Jiang, Xue Han, Xiaotong Yang, Liping Zhang, Baotong Chen, Aichun Liu   +10 more
doaj   +1 more source