Results 1 to 10 of about 13,695 (188)

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways

Frontiers in Pharmacology, 2022
The super-enhancer, a cluster of enhancers with strong transcriptional activity, has become one of the most interesting topics in recent years. This study aimed to investigate pathogenic super-enhancer–driven genes in IBD and screen therapeutic drugs ...
Hailong Li, Jinhe Li, Jinhe Li, Ting Xiao, Yayue Hu, Yayue Hu, Ying Yang, Xiaoting Gu, Ge Jin, Hailong Cao, Honggang Zhou, Honggang Zhou, Cheng Yang, Cheng Yang   +13 more
doaj   +5 more sources

Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization

Cell Reports, 2023
Summary: Macroautophagy/autophagy plays a pivotal role in immune regulation. Its significance is evident in modulation of immune cell differentiation and maturation, physiologically and pathologically.
Yongcheng Zhu, Yunyao Liu, Yuxiang Ma, Liu Chen, He Huang, Siting Huang, Huiling Zhang, Yuying He, Cheng Tan, Yuan He, Lei Qiang   +10 more
doaj   +5 more sources

Abnormal expression of CEBPB promotes the progression of renal cell carcinoma through regulating the generation of IL-6

Heliyon, 2023
Background: The CCAAT/enhancer-binding protein beta (CEBPB), a transcription factor regulating immune and inflammatory responses, has been implicated in the pathogenesis of various malignancies.
Yaoqiang Ren, Wenke Guo, Baoping Qiao
doaj   +3 more sources

CEBPB Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via CTLA4 Up-regulation in T Cells [PDF]

Cancer Communications
Background: Immune checkpoint inhibitors are ineffective in the majority of colorectal cancers (CRCs) that are microsatellite stable. However, the underlying reasons for their unresponsiveness and mechanisms of immune evasion are poorly understood.
Hye Jeong Yun, Chan Ho Park, Dahye Yun, Hye-Ri Shin, Jeong Dong Lee, Changhee Park, Kiyeon Kim, Heejun Shim, Hyejin Sim, Se Min Kim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Yoojoo Lim, Seung-Yong Jeong, Kyu Joo Park, Tae-You Kim, Junil Kim, Jae-Kyung Won, Sae-Won Han   +19 more
doaj   +2 more sources

Epigenetically-controlled CEBPB regulates kidney cancer tumorigenesis via GPD1L-mediated ether lipid synthesis [PDF]

Cell Death and Disease
Clear cell renal cell carcinoma (ccRCC) is characterized by disrupted lipid metabolism, traditionally attributed to VHL mutations and HIF stabilization.
Thi Ha Nguyen, Xuan Linh Mai, Tin Tin Manh Nguyen, Hoonsik Nam, Sunghyouk Park, Ji Yun Lee   +5 more
doaj   +2 more sources

CEBPB as a prognostic biomarker and its association with immune cells in clear cell renal cell carcinoma [PDF]

Biochemistry and Biophysics Reports
Clear cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy with a poor prognosis. This study examines the expression, prognostic significance, and immune association of CCAAT/enhancer-binding protein beta (CEBPB) in ccRCC.
Yaoqiang Ren, Min Wei, Quanfa Tian, Wenke Guo   +3 more
doaj   +2 more sources

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner [PDF]

Animals
N6-methyladenosine (m6A), a predominant and reversible modification of mammalian RNA, plays a critical role in regulating growth, development, and metabolism.
Hongyun Jiao, Lu Zhu, Xinyu Tang, Ping Gong, Wei Wang, Baolong Liu, Jun Luo   +6 more
doaj   +2 more sources

CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer [PDF]

Cancer Communications
Background: Liver metastasis represents the most common distant dissemination in gastric cancer (GC) but persists as a challenging condition to manage, and its driving molecular mechanisms remain poorly understood.
Zhixiang Zuo, Jiaqi Liang, Li-Na He, Kai Xu, Muren Hu, Kunming Zhang, Wei Gao, Junyi Yin, Lanlin Zhang, Boning Ma, Zhiqian Hu, Pengfei Zhang, Hong Jiang   +12 more
doaj   +2 more sources

CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma

Frontiers in Immunology, 2022
Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients ...
Jingrun Yang, Jingrun Yang, Yang Xu, Kuixia Xie, Ling Gao, Wenying Zhong, Xinhua Liu, Xinhua Liu   +7 more
doaj   +3 more sources

Doxorubicin induces ferroptosis in endometrial cancer by suppressing the MKK6/p38/CEBPB axis [PDF]

Journal of Translational Medicine
Background Doxorubicin is a cornerstone chemotherapeutic agent. However, its role in ferroptosis and the underlying molecular mechanisms in endometrial cancer (EC) remain inadequately explored.
Jingyan Zhang, Zhenhui Wang, Yanfang Li, Panpan Zhao, Dan Ren, Xiaoqin Lu   +5 more
doaj   +2 more sources