Results 71 to 80 of about 13,695 (188)

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

PI3Kγ is a molecular switch that controls immune suppression [PDF]

, 2016
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer1,2,3,4,5. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, whereas macrophages in neoplastic and ...
A Arranz, A Sica, Abraham V. Nguyen, AJ Gunderson, B Chaurasia, B Győrffy, B Ruffell, B Vanhaesebroeck, C Baer, CA Evans, Camila C. Figueiredo, Christopher J. Leem, David G. Winkler, EL Martin, Ezra E. W. Cohen, Gyunghwi Woo, Hongying Li, I Tabas, Jeffery Kutok, Judith A. Varner, Karen McGovern, Karen S. Messer, Kelly A. Frazer, M Martini, Matthew Rausch, MC Schmid, MC Schmid, MC Schmid, Megan M. Kaneda, Melissa Pink, Michael C. Schmid, Michael Karin, MJ Gray, MJ Rauh, MM Kaneda, N van Rooijen, Natacha Ralainirina, P Sharma, Philippe Foubert, Roman Sasik, S Yue, Sara Gorjestani, SL Topalian, SM Pyonteck, TA Wynn, V Byles, V Poli, Vito J. Palombella, Xuefeng Wu, Y Ben-Neriah   +49 more
core   +2 more sources

scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles. [PDF]

, 2020
Simultaneous measurements of transcriptomic and epigenomic profiles in the same individual cells provide an unprecedented opportunity to understand cell fates. However, effective approaches for the integrative analysis of such data are lacking.
Jin, Suoqin, Nie, Qing, Zhang, Lihua
core   +1 more source

Single‐Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations

Allergy, EarlyView.
Integrated single‐cell transcriptomics and large‐scale immunophenotyping reveal the molecular landscape of human basophils. Circulating basophils comprise two transcriptionally distinct populations. A user‐friendly web resource enables interactive exploration of the generated data.
Sofia Papavasileiou, Jiezhen Mo, Daryl Boey, Chenyan Wu, Magnus Tronstad, Lucille Margerie, Remi‐André Olsen, Jörg A. Bachmann, Jing Hui Low, Jocelyn Ong, Lars Heede Blom, Anand Kumar Andiappan, Gunnar Nilsson, Joakim S. Dahlin   +13 more
wiley   +1 more source

STAT1 activation in association with JAK2 exon 12 mutations [PDF]

, 2015
La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder ...
Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R., Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R.   +33 more
core   +4 more sources

Transcription factor CEBPB mediates intracranial aneurysm rupture by inflammatory and immune response

CNS Neuroscience & Therapeutics
AbstractIntroductionGenetic factors play a major part in mediating intracranial aneurysm (IA) rupture. However, research on the role of transcription factors (TFs) in IA rupture is rare.AimsBioinformatics analysis was performed to explore the TFs and related functional pathways involved in IA rupture.ResultsA total of 63 differentially expressed ...
Zhongbin Tian, Xuefang Wu, Baorui Zhang, Wei Li, Chao Wang   +4 more
openaire   +2 more sources

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex

Cell Death and Disease, 2023
Due to a lack of research on the critical non-coding RNAs in regulating ferroptosis, our study aimed to uncover the crucial ones involved in the process. We found that LINC01133 could make pancreatic cancer cells more resistant to ferroptosis.
Shaowen Wang, Jionghuang Chen, Pengping Li, Yangchao Chen   +3 more
doaj   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. [PDF]

, 2018
Genome-wide investigations of host-pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy.
Benner, Christopher, Branche, Emilie, Carlin, Aaron F, Glass, Christopher K, Heinz, Sven, Ley, Klaus, Shresta, Sujan, Suarez-Amaran, Lester, Viramontes, Karla M, Vizcarra, Edward A   +9 more
core  

CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength [PDF]

, 2015
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Declining muscle strength is a core feature of aging.
Bandinelli, S, Bradley-Smith, Rachel, Ferrucci, L, Guralnik, Jack, Harries, LW, Henley, William E., Hernandez, LD, Melzer, D, Pilling, LC, Singleton, AB   +9 more
core   +1 more source