Results 71 to 80 of about 10,537 (192)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex

Cell Death and Disease, 2023
Due to a lack of research on the critical non-coding RNAs in regulating ferroptosis, our study aimed to uncover the crucial ones involved in the process. We found that LINC01133 could make pancreatic cancer cells more resistant to ferroptosis.
Shaowen Wang, Jionghuang Chen, Pengping Li, Yangchao Chen   +3 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth

Allergy, EarlyView.
Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low, Xiaohui Man, Jocelyn Ong, Anna de Beer, Sofia Papavasileiou, Srinidhi Sudharson, Seohyun Kim, Yiping Fan, Hui Hua Liew, Alicia Tay, Shihui Foo, Shanshan W. Howland, Joakim S. Dahlin, Florent Ginhoux, Jerry Kok Yen Chan, Anand Kumar Andiappan   +15 more
wiley   +1 more source

CYP27B1 induction in response to TLR8 ligands is CEBPB-dependent.

, 2013
Macrophages transduced with non-specific scrambled shRNA (shNS) or CEBPB shRNA (shCEBPB) were treated for 24 h with CL097, ssRNA40, or ssRNA41. (A) Cells were lysed and immunoblot performed with antibodies to CEBPB and β-actin. (B) Immunoblots of CYP27B1
Stephen A. Spector (298587), Grant R. Campbell (298586)   +1 more
core   +1 more source

MiR-320 inhibits PRRSV replication by targeting PRRSV ORF6 and porcine CEBPB

Veterinary Research
Abstract Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV), results in huge economic losses to the world pig industry. MiRNAs have been reported to be involved in regulation of viral infection.
Gao, Xiaoxiao, You, Xiangbin, Wang, Guowei, Liu, Mengtian, Ye, Longlong, Meng, Yufeng, Luo, Gan, Xu, Dequan, Liu, Min   +8 more
openaire   +4 more sources

Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes [PDF]

Journal of Clinical Investigation, 2006
Anaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in vitro and in vivo and that ALK ...
PIVA, Roberto, PELLEGRINO, Elisa, MATTIOLI M, AGNELLI L, LOMBARDI L, BOCCALATTE F, COSTA, G, RUGGERI BA, CHENG M, CHIARLE, Roberto, PALESTRO, Giorgio, NERI A, INGHIRAMI, Giorgio   +12 more
openaire   +3 more sources

Additional file 4 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

, 2022
Additional file 4: Figure S4. (A) RNF145 expression was detected by qRT-PCR in different groups. (B) JASPAR database was applied to predict the binding sites of RNF145 to CEBPB. **P 
Bingyao Liu (6428873), Lei Zhu (16642), Juan Liu (6492), Yi Shuai (9176540), Bo Chen (32294), Ke Liu (121889), Maodian He (12336562), Junxia Li (136291), Lei Jin (120473), Xiaolei Shi (319891), Xinyao He (3109851), Liang Rong (3800992)   +11 more
core   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source