Results 91 to 100 of about 10,239 (195)

CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression

Medical Oncology
Ovarian cancer (OC) is among the most prevalent malignant tumors affecting the female reproductive system. Notably, CEBPB has emerged as a highly promising biomarker, attracting substantial attention for its role in mediating chemotherapy resistance to PARP inhibitors (PARPi).
Tan, Jiahong, Wang, Daoqi, Tu, Aiqing, Xu, Qin, Zhuan, Li, Wu, Xiaodie, Zhao, Lin, Dong, Wei, Zhang, Jie, Feng, Yun   +9 more
openaire   +2 more sources

Identification of target genes of transcription factor CEBPB in acute promyelocytic leukemia cells induced by all-trans retinoic acid [PDF]

, 2013
ObjectiveTo indentify target genes of transcription factor CCAAT enhancer-binding protein β (CEBPB) in acute promyelocytic leukemia cells induced by all-trans retinoic acid.MethodsA new strategy for high-throughput identification of direct target genes ...
Zhou, Jun, Zhang, Yang-De, Li, Xiang, Yao, De-Ming, Yu, Lei   +4 more
core   +1 more source

Restricted TCR Diversity and Expansion of CD177+CD8+ and TLR4+CD4+T Cell Subsets in Septic Shock‐Associated Immunosuppression: A Single‐Cell Multi‐Omics Study

MedComm, Volume 7, Issue 9, September 2026.
Our study enrolled 10 septic shock patients with immunosuppression and 10 healthy controls and sorted CD8+ and CD4+ T cells for transcriptome sequencing. Disease‐specific cell types, key transcripts, and TCR features were identified using integrated analysis.
Yawen Xie, Xunyao Wu, Guoyu Zhao, Xianli Lei, Jiahui Zhang, Na Cui, Bin Du   +6 more
wiley   +1 more source

METTL7A‐Dependent m6A Methylation Orchestrates CXCR4hi Neutrophil Pathogenicity and NETosis in Skin Inflammation

MedComm, Volume 7, Issue 9, September 2026.
In psoriasis, METTL7A is upregulated in aged CXCR4hi neutrophils, where it stabilizes PLSCR1 mRNA via m6A modification to enhance reactive oxygen species (ROS) production and neutrophil extracellular trap (NET) formation, thereby exacerbating disease severity.
Wanting Liu, Jinkai Liang, Huiyi Quan, Xuan Liu, Kang Li, Xin Tang, Jiaqi Wang, Yunfeng Gu, Yaxing Bai, Ke Xue, Zhiguo Li, Xiaolei Su, Erle Dang, Jiaoling Chen, Gang Wang, Shuai Shao   +15 more
wiley   +1 more source

Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BICRABL-expressing cells

, 2006
Translational regulation by oncogenic proteins may be a rapid and efficient mechanism to modulate gene expression. We report here the identification of the CEBPB gene as a target of translational regulation in myeloid precursor cells transformed by the ...
CALABRETTA, Bruno, Mariani SA, Perrotti D, Neviani P, Zhang Y, Panne ML, FERRARI, Giovanna, Martinez R, Bardini M, GUERZONI, Clara   +9 more
core   +1 more source

Additional file 4 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

, 2022
Additional file 4: Figure S4. (A) RNF145 expression was detected by qRT-PCR in different groups. (B) JASPAR database was applied to predict the binding sites of RNF145 to CEBPB. **P 
Bingyao Liu (6428873), Lei Zhu (16642), Juan Liu (6492), Yi Shuai (9176540), Bo Chen (32294), Ke Liu (121889), Maodian He (12336562), Junxia Li (136291), Lei Jin (120473), Xiaolei Shi (319891), Xinyao He (3109851), Liang Rong (3800992)   +11 more
core   +1 more source

Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
This study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa   +2 more
wiley   +1 more source

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

CEBPB and C19MC mark TNBCs and potentially drive TNBCs from other molecular sub-types of breast cancer.

, 2018
A, Schematic showing how CEBPB and REST play antagonistic roles in C19MC transcription to further regulate TNBC markers and REST mRNA to promote the triple negative status.
Andrew S. Brohl (596305), Elsa R. Flores (258494), Goodwin G. Jinesh (5870897)   +2 more
core   +1 more source

Prenatal Alcohol Exposure Produces Selective Changes in Neuroimmune Gene Expression Across Brain Regions of Adult Mice

Alcohol, Clinical and Experimental Research, Volume 50, Issue 9, September 2026.
PAE creates a unique inflammatory signature in the mature adult brain with region‐specific changes in genes implicated in glial‐immune function. We report at least 60 differentially expressed genes in different brain regions due to PAE, many of which are associated with neuroimmune function.
Alissa N. Jones, Ariana N. Pritha, Ashlynn M. Aguilar, Andrea A. Pasmay, Justin R. Carter, Nikolaos Mellios, Shahani Noor   +6 more
wiley   +1 more source