Results 91 to 100 of about 10,537 (192)

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

SMAD1,5,8 phosphorylation in hrBMP2-treated human endometrial stromal cells and SMAD1/5 and CEBPB ChIP experiments.

, 2013
A) Phosphorylation of SMAD1,5,8 in hESC treated with 100 ng/ml hrBMP2 for 0 (non treated = NT), 30, 45, 60 minutes, 3 or 6 hours. B-ACTIN was used as loading control. B) Phosphorylation of SMAD1,5,8 in hESC transfected with NT (left) or ALK2 siRNA (right)
Shannon M. Hawkins (251961), Swamy K. Tripurani (464062), Michael J. Large (485131), Stephanie A. Pangas (485132), Caterina Clementi (485130), Vesa Kaartinen (38989), Mark A. Edson (200197), John P. Lydon (476343), Francesco J. DeMayo (143652), Chad J. Creighton (81967), Martin M. Matzuk (200210), Ertug Kovanci (476340)   +11 more
core   +1 more source

CEBPB and C19MC mark TNBCs and potentially drive TNBCs from other molecular sub-types of breast cancer.

, 2018
A, Schematic showing how CEBPB and REST play antagonistic roles in C19MC transcription to further regulate TNBC markers and REST mRNA to promote the triple negative status.
Andrew S. Brohl (596305), Elsa R. Flores (258494), Goodwin G. Jinesh (5870897)   +2 more
core   +1 more source

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST.

PLoS ONE
A haplotype block at the sclerostin (SOST) gene correlates with bone mineral density (BMD) and increased periodontitis risk in smokers. Investigating the putative causal variants within this block, our study aimed to elucidate the impact of linked ...
Avneesh Chopra, Jiahui Song, January Weiner Rd, Dieter Beule, Arne S Schaefer   +4 more
doaj   +1 more source

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner

Animals
N6-methyladenosine (m6A), a predominant and reversible modification of mammalian RNA, plays a critical role in regulating growth, development, and metabolism.
Hongyun Jiao, Lu Zhu, Xinyu Tang, Ping Gong, Wei Wang, Baolong Liu, Jun Luo   +6 more
doaj   +1 more source

Identification of key genes and novel immune infiltration-associated biomarkers of sepsis

Innate Immunity, 2020
Sepsis is the major cause of mortality in the intensive care unit. The aim of this study was to identify the key prognostic biomarkers of abnormal expression and immune infiltration in sepsis.
Chao Xu, Jianbo Xu, Ling Lu, Wendan Tian, Jinling Ma, Meng Wu   +5 more
doaj   +1 more source

ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion

PNAS Nexus
Abstract ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β-cell line EndoC-βH1 did not impair
Wei Xuan Tan, Lillian Yuxian Lim, Nesha Afsha, Gloria Mei En Chan, Carmen Ching, Gokce Oguz, Suat Peng Neo, Safiah Mohamed Ali, Adaikalavan Ramasamy, Jayantha Gunaratne, Walter Hunziker, Chin Meng Khoo, Adrian Kee Keong Teo   +12 more
openaire   +2 more sources

Additional file 2 of Potential prognosis index for m6A-related mRNA in cholangiocarcinoma

, 2022
Additional file 2: Supplementary Fig. S1. Survival analysis of CHOL patients with m6A-related mRNA expression. A-E) Kaplan–Meier survival of AIP (A), CEBPB (B), SDC1 (C), VPS23 (D) and STXBP2 (E) in CHOL patient.
Chunqing Zhang (397606), Faji Yang (6753209), Xu Zhou (36698), Hengjun Gao (50821), Chaoqun Ma (1867639), Qingqiang Ni (12829006), Dongliang Wang (418198), Jun Lu (36049), Haini Zhao (12829000), Jianlu Wang (2568484), Huaqiang Zhu (7436468), Shuchao Zhao (12829003), Hongguang Li (829886)   +12 more
core   +1 more source

Multi-omics characterization of macrophage polarization-related features in osteoarthritis based on a machine learning computational framework

Heliyon
Background: OA imposes a heavy burden on patients and society in that its mechanism is still unclear, and there is a lack of effective targeted therapy other than surgery.
Ping Hu, Beining Li, Zhenyu Yin, Peng Peng, Jiangang Cao, Wanyu Xie, Liang Liu, Fujiang Cao, Bin Zhang   +8 more
doaj   +1 more source

Activation of KRT5, KRT14 and KRT17 enhancers mark the functional CEBPB activation.

, 2018
A, Schematic showing the enhancer regulatory factors that map to C19MC start site. B, RNASeq data showing CEBPB expression in C19MC-based patient groups.
Andrew S. Brohl (596305), Elsa R. Flores (258494), Goodwin G. Jinesh (5870897)   +2 more
core   +1 more source