Results 51 to 60 of about 42,856 (342)

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. [PDF]

, 2020
Death due to sepsis remains a persistent threat to critically ill patients confined to the intensive care unit and is characterized by colonization with multi-drug-resistant healthcare-associated pathogens.
Alverdy, John C, Antonopoulos, Dionysios A, Barreiro, Luis B, Bouziat, Romain, Christley, Scott, DeFazio, Jennifer R, Ernest, Jordan D, Fleming, Irma D, Gilbert, Jack A, Harris, Katharine G, Hyoju, Sanjiv K, Jabri, Bana, Keskey, Robert, Khodarev, Nikolai N, Kim, Sangman M, Krezalek, Monika A, Malik, Ankit, Ranoa, Diana R, Sangani, Kishan, Sangwan, Naseer, Shakhsheer, Baddr A, Weichselbaum, Ralph R, Wiegerinck, Mara, Zaborin, Alexander, Zaborina, Olga   +24 more
core  

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model [PDF]

, 2008
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora).
Allison C, Blum S, Cummings JH, Donaldson RM, Elaine Holmes, Fan TW, Francois‐Pierre J Martin, Fuller R, Ikram‐ul H, Ivan K S Yap, Jeremy K Nicholson, John C Lindon, Laurent B Fay, Macfarlane GT, Norbert Sprenger, Per Lek, Peter van Bladeren, Serge Rezzi, Sunil Kochhar, Torbjörn Lundstedt, Yulan Wang, Zeisel SH, Ziad Ramadan   +22 more
core   +2 more sources

Ketamine inhibits TNF-α-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS

Cell Death Discovery, 2022
Systemic inflammatory response syndrome (SIRS) is a sepsis-associated inflammatory state and a self-defense mechanism against specific and nonspecific stimuli. Ketamine influences many key processes that are altered during sepsis. However, the underlying
Bin Deng, Daowei Yang, Huanghui Wu, Lu Wang, Rui Wu, Hongrui Zhu, Ailing Huang, Jingyi Song, Tieliang Cai, Shanshan Liu, Jingsi Wu, Huiying Zhou, Chunhui Li   +12 more
doaj   +1 more source

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice [PDF]

, 2013
Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global ...
Brinkman, Brigitta, Cauwe, Benedicte, Garcia Yunta, Roberto, Hildebrand, Falk, Liston, Adrian, Nguyen, (Thi Loan Anh, Raes, Jeroen, Vandenabeele, Peter   +7 more
core   +3 more sources

Tissue-resident, memory CD8+ T cells are effective in clearing intestinal Eimeria falciformis reinfection in mice

Frontiers in Immunology, 2023
Eimeria, a cousin of malarial parasites, causes coccidiosis that results in huge losses in the poultry industry. Although live coccidiosis vaccines have been developed and used widely for the successful control of the disease, the mechanism underlying ...
Fangyun Shi, Fangyun Shi, Fangyun Shi, Sixin Zhang, Sixin Zhang, Ning Zhang, Ning Zhang, Ying Yu, Ying Yu, Pei Sun, Xinming Tang, Xianyong Liu, Xianyong Liu, Xianyong Liu, Xun Suo, Xun Suo, Xun Suo   +16 more
doaj   +1 more source

Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. [PDF]

, 2018
Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by ...
Alexander, Walker, Dilbarova, Rima, Gilligan, John, Hoxha, Kevther, Kossenkov, Andrew, Mullin, James M., Prendergast, George C., Thomas, Sunil, Whittaker, Kelly   +8 more
core   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Utilization of Pyrosequencing to Monitor the Microbiome Dynamics of Probiotic Treated Poultry (Gallus gallus domesticus) during Downstream Poultry Processing [PDF]

, 2017
Antibiotic growth promoters that have been historically employed to control pathogens and increase the rate of animal development for human consumption are currently banned in many countries.
Bray, Joey, Clack, Beatrice, Guttala, Vamsy Priya, Medrano, Enrique G.   +3 more
core   +3 more sources

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source