Results 61 to 70 of about 42,856 (342)

The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome [PDF]

, 2014
Studies with dietary supplementation of various types of fibers have shown beneficial effects on symptoms of the metabolic syndrome. Short-chain fatty acids (SCFAs), the main products of intestinal bacterial fermentation of dietary fiber, have been ...
Bakker, Barbara M, Bleeker, Aycha, den Besten, Gijs, Gerding, Albert, Groen, Albert K, Havinga, Rick, Rao, Shodhan, Reijngoud, Dirk-Jan, van Eunen, Karen   +8 more
core   +7 more sources

Eimeria maxima-induced transcriptional changes in the cecal mucosa of broiler chickens

Parasites & Vectors, 2019
Background Apicomplexan protozoans of the genus Eimeria cause coccidiosis, one of the most economically relevant parasitic diseases in chickens. The lack of a complete understanding of molecular mechanisms in the host-parasite interaction limits the ...
Charles Li, Xianghe Yan, Hyun S. Lillehoj, Sungtaek Oh, Liheng Liu, Zhifeng Sun, Changqin Gu, Youngsub Lee, Zhezi Xianyu, Hongyan Zhao   +9 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Anti-Inflammatory Effects of Idebenone Attenuate LPS-Induced Systemic Inflammatory Diseases by Suppressing NF-κB Activation

Antioxidants
Inflammation is a natural protective process through which the immune system responds to injury, infection, or irritation. However, hyperinflammation or long-term inflammatory responses can cause various inflammatory diseases.
Yumin Choi, Young-Lai Cho, Sujeong Park, Minkyung Park, Keun-Seok Hong, Young Jun Park, In-Ah Lee, Su Wol Chung, Heedoo Lee, Seon-Jin Lee   +9 more
doaj   +1 more source

Poultry as a host for the zoonotic pathogen Campylobacter jejuni [PDF]

, 2012
Campylobacteriosis is the most reported foodborne gastroenteritic disease and poses a serious health burden in industrialized countries. Disease in humans is mainly caused by the zoonotic pathogen Campylobacter jejuni.
Haesebrouck, Freddy, Hermans, David, Heyndrickx, Marc, Martel, An, Messens, Winy, Pasmans, Frank, Rasschaert, Geertrui, Van Deun, Kim, Van Immerseel, Filip   +8 more
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Divertículo único do ceco: experiência de um hospital geral brasileiro Solitary diverticulum of the cecum: experience of a Brazilian general hospital

Arquivos de Gastroenterologia, 2003
RACIONAL: A diverticulite cecal é uma condição rara, especialmente em populações ocidentais. Sua importância reside no fato de fazer parte do diagnóstico diferencial da apendicite aguda e do carcinoma ulcerado de ceco.
Aljamir Duarte Chedid, Luciano Amaral Domingues, Marcio Fernandes Chedid, Maitê de Mello Villwock, Antônio Renato Mondelo   +4 more
doaj   +1 more source

Experimental infection of newly weaned pigs with human and porcine strains of Serpulina pilosicoli [PDF]

, 1996
Cultures of Serpulina pilosicoli 95/1000, isolated from a pig with porcine intestinal spirochetosis (PIS), and S. pilosicoli WesB, isolated from an Aboriginal child with diarrhea, were used to infect 5-week-old newly weaned pigs. Four of 12 pigs infected
Trott, D.J., Huxtable, C.R., Hampson, D.J.   +2 more
core   +1 more source

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. [PDF]

, 2020
ObjectivesThe intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that
Chan, Hung, Chan, Matthew TV, Cho, Chi H, Gallo, Richard L, Gin, Tony, Ho, Idy HT, Ho, Jeffery, Hu, Wei, Leung, Czarina CH, Li, Qing, Liang, Yonghao, Ling, Lowell, Liu, Xiaodong, Tse, Gary, Ugwu, Felix N, Wong, Sunny H, Wong, Wai Tat, Wu, William KK, Yau, Johnny CW, Yu, Jun, Zeng, Judeng, Zhang, Lin, Zhang, Yuchen   +22 more
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source