Results 71 to 80 of about 44,409 (342)

A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice [PDF]

, 2019
Sepsis is a complex syndrome resulting from a dysregulated immune response to an infection. Due to the high prevalence, morbidity, and mortality, there is a lot of interest in understanding pathways that play a role in sepsis, with a focus on the immune ...
Eggermont, Melanie, Libert, Claude, Steeland, Sophie, Van Ryckeghem, Sara, Van Wonterghem, Elien, Vandenbroucke, Roosmarijn, Vandewalle, Jolien   +6 more
core   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Pasture intake protects against commercial diet-induced lipopolysaccharide production facilitated by gut microbiota through activating intestinal alkaline phosphatase enzyme in meat geese

Frontiers in Immunology, 2022
IntroductionDiet strongly affects gut microbiota composition, and gut bacteria can influence the intestinal barrier functions and systemic inflammation through metabolic endotoxemia.
Qasim Ali, Sen Ma, Sen Ma, Sen Ma, Umar Farooq, Jiakuan Niu, Fen Li, Defeng Li, Defeng Li, Defeng Li, Zhichang Wang, Zhichang Wang, Zhichang Wang, Hao Sun, Hao Sun, Hao Sun, Yalei Cui, Yalei Cui, Yalei Cui, Yinghua Shi, Yinghua Shi, Yinghua Shi   +21 more
doaj   +1 more source

Phytochemicals as antibiotic alternatives to promote growth and enhance host health [PDF]

, 2018
There are heightened concerns globally on emerging drug-resistant superbugs and the lack of new antibiotics for treating human and animal diseases. For the agricultural industry, there is an urgent need to develop strategies to replace antibiotics for ...
A Costabile, A Djeridane, A Foskolos, A Piñeiro-Vázquez, A Scalbert, A Sivropoulou, AJ Moeser, AK Patra, AM Elizondo, AS Neish, B Nagy, BB Oakley, BR Min, BR Min, C Benchaar, C Benchaar, C Cabral, C Jobin, C Oguey, C Rivera-Méndez, CF Carson, Cyril G. Gay, D Bravo, D Bravo, D Bravo, D Ferme, D Stanley, DK Kim, DK Kim, DK Kim, DK Kim, EG Manzanilla, EH Wall, EH Wall, EN Bergman, F Bäckhed, F Mathieu, Fang Chi, GG Han, HK Allen, HS Lillehoj, HS Lillehoj, HS Lillehoj, Hyun Lillehoj, I Fandiño, J Guban, J Lin, J Michiels, J Oh, J Oh, J Oh, J Oh, J Snel, J Xu, JA Patterson, JA Tekippe, JB Furness, JC McCann, JE Kim, JIR Castanon, JK Nicholson, JL Danzeisen, JM Diaz Carrasco, JM Díaz Carrasco, JM Fairbrother, JM Powell, JT Vasconcelos, K Stelwagen, KD Economou, KW Lee, L Reddy, LM Cox, LM Redondo, LM Redondo, LR Tager, LZ Jin, M Busquet, M Busquet, M Nakphaichit, M Nofrarias, M Rodríguez-Prado, MA Hildebrandt, Mariano E. Fernandez-Miyakawa, MJ Aguerre, MJ Sergeant, N French, N Noohi, NM Delzenne, NO Kaakoush, P Singh, P Trouillas, PJ Aar Van der, PL Teissedre, PTN Lan, PTN Lan, PW Cardozo, PW Cardozo, R Barajas, R Barajas, R Budriesi, R Mezzomo, R Mezzomo, RE Ley, RJ Wallace, RJW Lambert, Ron L. Cravens, S Ankri, S Calsamiglia, S Fukuda, S Krishnan, S Tamminga, SA Burt, SD Cox, Sergio Calsamiglia, SH Lee, SH Lee, SH Lee, SH Lee, SH Lee, SH Lee, SK Shabat, ST Oh, Sungtaek Oh, SYY Wong, T Frankič, T Hino, T Mašek, T Settle, TF Duffield, TF Duffield, TL Miller, TR Callaway, U Gadde, V Vasta, VA Torok, W Windisch, WH Kim, Y Lee, Y Liu, Y Liu, Y Liu, Y Liu, Y Nagano, Yanhong Liu, YW Min, Ì Gülçin   +145 more
core   +5 more sources

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive. To address this challenge, we developed a novel nano‐vaccine that combines Prussian blue nanozymes (PBNZs) adjuvants with a ferritin carrier loaded with ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source

Anti-microbial Use in Animals: How to Assess the Trade-offs [PDF]

, 2015
Antimicrobials are widely used in preventive and curative medicine in animals. Benefits from curative use are clear – it allows sick animals to be healthy with a gain in human welfare.
Acar J. F., Codex Alimentarius, Cogliani C., Davies S., Graham J. P., J. Rushton, McEwen S. A., Pagel S. W., Rushton J., Rushton J., Steinfeld H., Tisdell C., Wegener H. C.   +12 more
core   +2 more sources

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Cecal volvulus on top of Ladd’s band: a case report and review of literature

Bulletin of the National Research Centre
Background Cecal volvulus is a rare cause of bowel obstruction that represents a challenge in both diagnosis and management. This unique form of closed-loop obstruction occurs due to a twist in the mesentery with subsequent dilatation of the cecum.
Mohamed Salah Ayyad, Abdallah Alqasaby, Mohamed Rezk, Ahmed Abonosier, Shaimaa Khalid, Ahmed Azam   +5 more
doaj   +1 more source

Populations of Eimeria tenella express resistance to commonly used anticoccidial drugs in southern Nigeria

International Journal of Veterinary Science and Medicine, 2018
Coccidiosis is one of the most economically important diseases of poultry. This study determined the preponderance of chicken Eimeria in southern Nigeria and assessed the parasite’s resistance to three anticoccidial drugs: Amprolium hydrochloride ...
Agatha E. Ojimelukwe, Deborah E. Emedhem, Gabriel O. Agu, Florence O. Nduka, Austin E. Abah   +4 more
doaj   +1 more source