Results 61 to 70 of about 71,313 (308)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Chicken deubiquitinases in spleen, cecum and liver

, 2021
This study entails a chemical proteomic experiment performed to identify deubiquitinases in the chicken tissues, including spleen, cecum, and liver, based on the reactivity of these enzymes with active site-directed ...
Edelmann, M (via Mendeley Data)
core   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Marked Response in Microbial Community and Metabolism in the Ileum and Cecum of Suckling Piglets After Early Antibiotics Exposure

Frontiers in Microbiology, 2018
In modern swine husbandry systems, antibiotics have been used as growth promoters for piglets during suckling or weaning period. However, while early colonization of intestinal microbiota has been regarded crucial for the host’s later life performance ...
Miao Yu, Miao Yu, Miao Yu, Chunlong Mu, Chunlong Mu, Chuanjian Zhang, Chuanjian Zhang, Yuxiang Yang, Yuxiang Yang, Yong Su, Yong Su, Weiyun Zhu, Weiyun Zhu   +12 more
doaj   +1 more source

The Responses of Lactobacillus reuteri LR1 or Antibiotic on Intestinal Barrier Function and Microbiota in the Cecum of Pigs

Frontiers in Microbiology, 2022
This study aimed to investigate responses of the Lactobacillus reuteri or an antibiotic on cecal microbiota and intestinal barrier function in different stages of pigs.
Bijing Yang, Bijing Yang, Chunyan Liu, Chunyan Liu, Yanna Huang, Qiwen Wu, Yunxia Xiong, Xuefen Yang, Shenglan Hu, Zongyong Jiang, Li Wang, Hongbo Yi   +11 more
doaj   +1 more source

Bowel wall thickening and mucosal folding in the cecum.

, 2021
Bowel wall thickening and mucosal folding in the cecum.
Si-Guo Liu (11402414), Hui-Xin Cheng (11402387), Jin-Ling Wang (11402384), Wei-Hong Zhao (672623), Zeng-Qiang Miao (11402399), Yu-Lin Ding (11402402), Li Zhao (147498), Yong-Hong Liu (4745961), Jirintai Sulijid (11402405), Hai-Liang Chai (11402393), Shu-Ying Liu (785775), Yu Wang (12152), Yi-Min Ma (11402390), Li-Feng Wang (149916), Guang-Hui Dang (11402408), Zhan-Sheng Zhang (11402396), Feng-Long Wang (11402411)   +16 more
core   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Primary B-Cell Lymphoma of Caecum Presenting as an Ulcerative Lesion in a Young Male

Journal of Digestive Endoscopy, 2020
Extra nodal site of non–Hodgkin’s lymphoma is mostly in the gastrointestinal tract. Large intestine is rarely affected compared with stomach or small bowel. The colon is affected in 0.4% of cases approximately.
Arvind Bamanikar, Swapnil Patil, Shivam Sharma   +2 more
doaj   +1 more source