Results 51 to 60 of about 7,241 (141)

Assessing the mechanistic synergy between cancer virotherapy and external beam radiation

, 2021
One of the core radiobiological features determining response to fractionated treatment is repair of ionising radiation-mediated damage. Adenoviruses are shown to inhibit the DNA damage response (DDR), in particular the pathways involved in repairing ...
Pokrovska, Tzveta
core   +1 more source

European mistletoe shares a similar demographic strategy with non‐parasitic plants

Journal of Ecology, Volume 114, Issue 5, May 2026.
European mistletoe (Viscum album) does not have a distinct demographic strategy from non‐parasitic plants, as quantified by time‐based life history traits. We found that mistletoe vital rates were driven by mistletoe size and position in the host tree.
Oliver G. Spacey, Owen R. Jones, Sydne Record, Sharon D. Janssen, Arya Y. Yue, Wenyi Liu, Alice Rosen, Chris J. Thorogood, Roberto Salguero‐Gómez   +8 more
wiley   +1 more source

Newly development of liposomes vaccines using influenza virus and T cell epitope peptide derived from Japanese cedar pollen

, 2013
リポソームカプセルのリン脂質2重層にNKT細胞活性化物質「α-GalCer」を挿入し、スギ花粉T細胞エピトープを封入し、CTLエピトープを表面に結合することによってリポソームワクチンを構築した。インフルエンザウイルス感染およびスギ花粉症モデルマウスを対象に、リポソームワクチンを6日間、予防的に投与し、IFV抗体価を指標として検討した結果、新しいインフルエンザウイルスワクチンの有効性が証明された。We constructed liposomes vaccines, in α-GalCe, an ...
44, 中村, 裕之, 30231476
core   +1 more source

Henipavirus Infections: Lessons from Animal Models

Pathogens, 2013
The Henipavirus genus contains two highly lethal viruses, the Hendra and Nipah viruses and one, recently discovered, apparently nonpathogenic member; Cedar virus.
Kévin P. Dhondt, Branka Horvat
doaj   +1 more source

Making sense of TILs: recommendations for morphological assessment of tumour‐infiltrating lymphocytes in gastro‐oesophageal carcinoma

Histopathology, Volume 88, Issue 6, Page 1126-1141, May 2026.
This review examines the role of tumour‐infiltrating lymphocytes (TILs) in gastro‐oesophageal carcinoma (GEC), focusing on their composition, clinical relevance and therapeutic utility. It proposes a framework for standardised evaluation and reporting of TILs, addressing GEC‐specific pathology challenges to support the widespread use and validation of ...
Ylva A Weeda, Roberto Salgado, Filip van Herpe, Daniel Sur, Michael Vieth, Sherene Loi, Ahmad P Tafti, Hardas Alexandros, Akira I Hida, Amarpreet Bhalla, Andrey I Khramtsov, Anna Ehinger, Atsushi Tanaka, Balazs Acs, Caner Ercan, Cornelia M Focke, Daniel Ehinger, Dan Huang, Galina F Khramtsova, Haruto Nishida, Nianyi Li, Nickolas Littlefield, Sanna Steen, Selim Sevim, Shin Ichihara, Shinnosuke Morikawa, Stefan Michiels, Thomas Papathomas, Toshihiro Haga, Qiangqiang Gu, Weiqi Sheng, Hoel Kervadec, Hugo M Horlings, Francisco Sanchez‐Vega, Yelena Y Janjigian, Myriam Chalabi, Hanneke W M van Laarhoven, Liudmila L Kodach, Sybren L Meijer   +38 more
wiley   +1 more source

Use of En Bloc Kidney Allografts for Pediatric Kidney‐Alone and Multiorgan Transplant Recipients in the United States

Pediatric Transplantation, Volume 30, Issue 5, May 2026.
Despite policy changes in the United States designed to increase the use of en bloc kidneys, utilization in pediatric recipients has declined sharply over time. In the current era, en bloc kidneys are used primarily in pediatric multiorgan recipients. However, in a select population, they can have good long‐term outcomes.
Rachel M. Engen, James D. Perkins, Lyndsay A. Harshman, Clare Lindner, Juhi Kumar, Dechu Puliyanda, Sharon M. Bartosh, Jodi M. Smith   +7 more
wiley   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, Volume 66, Issue S1, Page S266-S277, May 2026.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Cardiovascular event rates rise after acute infections. After a single pyelonephritis episode in Ldlr−/− mice, atherosclerotic plaque necrotic core size increased, mediated by chemokine receptor CCR2‐induced monocyte mobilization from the bone marrow.
Lena Possenriede, Peyman Falahat, Marie Foerster, Georg W. Sendtner, Julia Miranda, Leonie Richard‐Stropahl, Uta Scheidt, Christian Kurts, Florian Wagenlehner, Ekaterina K. Koltsova, Sibylle von Vietinghoff   +10 more
wiley   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Created in BioRender. Haralambie, O. (2025) https://BioRender.com/dh5ly89. ABSTRACT Digestive disorders such as inflammatory bowel disease (IBD) and colorectal cancer are among the most significant global health challenges, largely driven by chronic inflammation and oxidative stress.
Oana‐Roxana Haralambie, Sanda Andrei
wiley   +1 more source