Results 31 to 40 of about 1,106,036 (151)

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response. [PDF]

PLoS Pathogens, 2016
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system.
Preeti Bharaj, Yao E Wang, Brian E Dawes, Tatyana E Yun, Arnold Park, Benjamin Yen, Christopher F Basler, Alexander N Freiberg, Benhur Lee, Ricardo Rajsbaum   +9 more
doaj   +1 more source

Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions

Frontiers in Cellular and Infection Microbiology, 2020
Influenza A virus (IAV) is a threat to public health due to its high mutation rate and resistance to existing drugs. In this investigation, 15 targets selected from an influenza virus–host interaction network were successfully constructed as a ...
Lvjie Xu, Wen Jiang, Hao Jia, Lishu Zheng, Jianguo Xing, Ailin Liu, Guanhua Du   +6 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Additional file 1 of The role of N-linked glycosylation in proteolytic processing and cell surface transport of the Cedar virus fusion protein

, 2022
Additional file 1: Sequence information for codon-optimized CedV F HAtag gene. Start and stop codon are highlighted in bold and are underlined. CedV F gene was codon-optimized according to the human codon usage bias and synthesized by Gene Art. Additionally, the coding information for an HA-Tag was included.
Fischer, Kerstin, Topallar, Selin, Kraatz, Franziska, Groschup, Martin H., Diederich, Sandra   +4 more
openaire   +1 more source

Nonhuman Pedagogical Relations: Towards Conceptual Limits

Educational Theory, EarlyView.
Abstract This article considers the pedagogical relation as a relation to a nonhuman educator, wherein the educatee is a member of the Homo sapiens species. My aim is to clarify the extent to which a nonhuman‐human relation can be understood as pedagogical.
Silas C. Krabbe
wiley   +1 more source

Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion, EarlyView.
Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean‐Michel Pawlotsky, Syria Laperche, Daniel Candotti   +8 more
wiley   +1 more source

Privacy‐preserving multi‐agent systems for human‐centred inclusive healthcare AI

AI Magazine, Volume 47, Issue 3, Fall 2026.
ABSTRACT Healthcare environments present uniquely demanding constraints for the deployment of artificial intelligence (AI). Clinical decisions of significant consequence are rarely the product of a single isolated computation; rather, safe and effective patient care relies on the continuous collaboration of distributed entities, including clinicians ...
Mufti Mahmud, Noushath Shaffi, M Shamim Kaiser, M Arifur Rahman, M Mostafizur Rahman, Vimbi Viswan, Tamanna Sharmeen, Sweta Bhattacharya, Neelu Jyoti Ahuja, Ayse Ulgen, Imran Khan Niazi, Kanad Ray, Amir Hussain, David J Brown, Jason H. Moore   +14 more
wiley   +1 more source

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses

Pathogens
Recent advances in high-throughput sequencing technologies have led to the discovery of a plethora of previously unknown viruses in animal samples. Some of these newly detected viruses are closely related to human pathogens.
Kristina Meier, Judith Olejnik, Adam J. Hume, Elke Mühlberger   +3 more
doaj   +1 more source

Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno‐Free Culture Systems

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
Advances in cell sources, bioengineering, and manufacturing are reshaping the design of skin substitutes. This review highlights emerging strategies driving skin tissue engineering and discusses their potential to enable safer, reproducible, and clinically accessible skin substitutes for regenerative medicine.
Gilles Lemaître, Marina Trouillas, Tatiana Vinasco‐Sandoval, Cécile Giordano, Alexandre G. Lellouch, Walid Rachidi, Jean‐Jacques Lataillade, Nicolas O. Fortunel   +7 more
wiley   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source