Results 11 to 20 of about 26,214 (161)

A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery. [PDF]

Antiviral Res, 2021
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic, bat-borne paramyxoviruses in the genus Henipavirus that cause severe and often fatal acute respiratory and/or neurologic diseases in humans and livestock. There are currently no approved antiviral therapeutics or vaccines for use in humans to treat or prevent NiV or HeV infection.
Amaya M, Cheng H, Borisevich V, Navaratnarajah CK, Cattaneo R, Cooper L, Moore TW, Gaisina IN, Geisbert TW, Rong L, Broder CC.   +10 more
europepmc   +5 more sources

Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells [PDF]

Viruses
Cedar virus (CedV), closely related to the Hendra and Nipah viruses, is a novel Henipavirus that was originally isolated from flying foxes in Australia in 2012. Although its glycoprotein G exhibits relatively low sequence similarity with its counterparts
Lea Lenhard, Martin Müller, Sandra Diederich, Lisa Loerzer, Virginia Friedrichs, Bernd Köllner, Stefan Finke, Anca Dorhoi, Gang Pei   +8 more
doaj   +4 more sources

Rousettus aegyptiacus Fruit Bats Do Not Support Productive Replication of Cedar Virus upon Experimental Challenge [PDF]

Viruses
Cedar henipavirus (CedV), which was isolated from the urine of pteropodid bats in Australia, belongs to the genus Henipavirus in the family of Paramyxoviridae.
Björn-Patrick Mohl, Sandra Diederich, Kerstin Fischer, Anne Balkema-Buschmann   +3 more
doaj   +4 more sources

Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. [PDF]

Proc Natl Acad Sci U S A, 2019
Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra virus (HeV), zoonotic agents of fatal human disease. CedV receptor-binding protein (G) shares only ∼30% sequence identity with those of NiV and HeV, although they can all use ephrin-B2 as an entry receptor. We demonstrate that CedV also enters cells through additional
Laing ED, Navaratnarajah CK, Cheliout Da Silva S, Petzing SR, Xu Y, Sterling SL, Marsh GA, Wang LF, Amaya M, Nikolov DB, Cattaneo R, Broder CC, Xu K.   +12 more
europepmc   +6 more sources

Tetracistronic minigenomes elucidate a functional promoter for Ghana virus and unveils Cedar virus replicase promiscuity for all henipaviruses. [PDF]

J Virol
AbstractBatborne henipaviruses, such as Nipah virus and Hendra virus, represent a major threat to global health due to their propensity for spillover, severe pathogenicity, and high mortality rate in human hosts. Coupled with the absence of approved vaccines or therapeutics, work with the prototypical species and uncharacterized, emergent species is ...
Haas GD, Kowdle S, Schmitz KS, Azarm KD, Johnson KN, Klain WR, Freiberg AN, Cox RM, Plemper RK, Lee B.   +9 more
europepmc   +6 more sources

Analysis of Recombinant Cedar Virus Infection and Cross-Protection Against Related Henipaviruses in African Green Monkeys [PDF]

Viruses
Cedar virus (CedV), related to the highly pathogenic bat-borne henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), is non-pathogenic in small animal models, likely due to the inability to produce interferon-antagonist proteins.
Declan D. Pigeaud, Moushimi Amaya, Viktoriya Borisevich, Karla A. Fenton, Krystle N. Agans, Courtney Woolsey, Antony S. Dimitrov, Abhishek N. Prasad, Natalie S. Dobias, Daniel J. Deer, Joan B. Geisbert, Robert W. Cross, Christopher C. Broder, Thomas W. Geisbert   +13 more
doaj   +2 more sources

Serologic Evidence of Human Exposure to Bat-Borne Zoonotic Paramyxoviruses, Cambodia [PDF]

Viruses
Fruit bats in the genus Pteropus are the natural reservoirs for zoonotic paramyxoviruses, notably henipaviruses and pararubulaviruses, which are found across Southeast Asia and Oceania.
Neil Mittal, Spencer L. Sterling, Phireak Hip, Dolyce H. W. Low, Piseth Ly, Menghou Mao, Pidor Ouch, Adrian C. Paskey, Lianying Yan, Alan Hitch, Gavin J. D. Smith, Jeffery Hertz, Andrew G. Letizia, Ian H. Mendenhall, Eric D. Laing   +14 more
doaj   +2 more sources

An in vivo BSL-2 model for henipavirus infection based on bioluminescence imaging of recombinant Cedar virus replication in mice. [PDF]

Front Chem Biol
Henipaviruses are enveloped single-stranded, negative-sense RNA viruses of the paramyxovirus family. Two henipaviruses, Nipah virus and Hendra virus, cause a systemic respiratory and/or neurological disease in humans and ten additional species of mammals, with a high fatality rate. Because of their highly pathogenic nature, Nipah virus and Hendra virus
Huaman C, Clouse C, Rader M, Yan L, Bai S, Gunn BM, Amaya M, Laing ED, Broder CC, Schaefer BC.   +9 more
europepmc   +3 more sources

Trafficking and Activation of Henipavirus, Parahenipavirus, and Henipa-like Virus Fusion Proteins [PDF]

Viruses
Henipaviruses are emerging zoonotic viruses that have caused deadly outbreaks in humans and livestock across several regions of the world. The fusion (F) protein of henipaviruses plays a critical role in viral entry into host cells and represents a key ...
Chanakha K. Navaratnarajah, Roberto Cattaneo   +1 more
doaj   +2 more sources

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR) [PDF]

Radiation Oncology, 2020
Background Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxicity and/or absence of increased ...
Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan, Maria A. Hawkins   +10 more
doaj   +7 more sources