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Henipavirus Infections: Lessons from Animal Models [PDF]

Pathogens, 2013
The Henipavirus genus contains two highly lethal viruses, the Hendra and Nipah viruses and one, recently discovered, apparently nonpathogenic member; Cedar virus.
Kévin P. Dhondt, Branka Horvat
doaj   +8 more sources

Distinct Cell Transcriptomic Landscapes Upon Henipavirus Infections [PDF]

Frontiers in Microbiology, 2020
Hendra virus (HeV) and Cedar virus (CedV) are henipaviruses, which fall into the Paramyxoviridae family of single-stranded, negative-sense RNA viruses. HeV is classified as a Biosafety Level-4 (BSL-4) agent, as it is highly pathogenic and is often fatal ...
Mingyue Chen, Mingyue Chen, Mingyue Chen, Mary Tachedjian, Glenn A. Marsh, Jie Cui, Jie Cui, Lin-Fa Wang, Lin-Fa Wang   +8 more
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Henipavirus in Northern Short-Tailed Shrew, Alabama, USA [PDF]

Emerging Infectious Diseases
RNA metagenomic analysis of tissues from 4 wild-caught northern short-tailed shrews in Alabama, USA, revealed a novel henipavirus (family Paramyxoviridae).
Rhys H. Parry, KayLene Y.H. Yamada, Wendy R. Hood, Yang Zhao, Jinlong Y. Lu, Andrei Seluanov, Vera Gorbunova, Naphak Modhiran, Daniel Watterson, Ariel Isaacs   +9 more
doaj   +3 more sources

Trafficking and Activation of Henipavirus, Parahenipavirus, and Henipa-like Virus Fusion Proteins [PDF]

Viruses
Henipaviruses are emerging zoonotic viruses that have caused deadly outbreaks in humans and livestock across several regions of the world. The fusion (F) protein of henipaviruses plays a critical role in viral entry into host cells and represents a key ...
Chanakha K. Navaratnarajah, Roberto Cattaneo   +1 more
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Genetic Diversity and Geographic Spread of Henipaviruses [PDF]

Emerging Infectious Diseases
Henipaviruses, such as Hendra and Nipah viruses, are major zoonotic pathogens that cause encephalitis and respiratory infections in humans and animals.
Yakhouba Kane, Betty Nalikka, Alexander Tendu, Victor Omondi, Kathrina Mae Bienes, Abdou Padane, Veasna Duong, Nicolas Berthet, Gary Wong   +8 more
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Serological and molecular analysis of henipavirus infections in synanthropic fruit bat and rodent populations in the Centre and North regions of Cameroon (2018–2020) [PDF]

BMC Veterinary Research
Background Bats and rodents have been identified as reservoirs for several highly pathogenic and zoonotic viruses including henipaviruses, a genus within the Paramyxoviridae family.
Cyrille Mbanwi Mbu’u, Pierre Gontao, Abel Wade, Maren Penning, Balal Sadeghi, Aristid Ekollo Mbange, Matthew LeBreton, Sylvain Leroy Sado Kamdem, Franziska Stoek, Martin Hermann Groschup, Wilfred Fon Mbacham, Anne Balkema-Buschmann   +11 more
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The Current Pathogenicity and Potential Risk Assessment of Nipah Virus as Potential Cause of “Disease X”: A Narrative Review

Health Science Reports
Background and Aims The World Health Organization (WHO) recognized the potential for a severe international epidemic and introduced the term “Disease X” to classify pathogens that not yet identified.
Samiha Mehnaz, Ramisa Anjum, Fatema Rahman Mithila, Syed Masudur Rahman Dewan, Md. Rabiul Islam   +4 more
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From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology
Zoonotic infections are increasingly observed and bats (Chiroptera) are playing a pivotal role here. The causal chain of events has been elucidated for Henipavirus (family: paramyxoviruses) infections.
Harald Brüssow
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Ecological and Reproductive Cycles Drive Henipavirus Seroprevalence in the African Straw‐Coloured Fruit Bat (Eidolon helvum) [PDF]

Ecology and Evolution
Bats are known to host zoonotic viruses, including henipaviruses that cause high fatality rates in humans (Nipah virus and Hendra virus). However, the determinants of zoonotic spillover are generally unknown, as the ecological and demographic drivers of ...
Maya M. Juman, Louise Gibson, Richard D. Suu‐Ire, Sylvester Languon, Osbourne Quaye, Grace Fleischer, Samuel Asumah, E. Rosa Jolma, Avinita Gautam, Spencer L. Sterling, Lianying Yan, Christopher C. Broder, Eric D. Laing, James L. N. Wood, Andrew A. Cunningham, Olivier Restif   +15 more
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Characterization of an mRNA-Encoded Antibody Against Henipavirus [PDF]

Current Issues in Molecular Biology
Nipah and Hendra viruses are lethal zoonotic pathogens with no approved vaccines or therapeutics. mRNA produced via in vitro transcription enables endogenous protein expression and cost reduction.
Zixuan Liu, Bingjie Sun, Ting Fang, Xiaofan Zhao, Yi Ren, Zhenwei Song, Sijun He, Jianmin Li, Pengfei Fan, Changming Yu   +9 more
doaj   +2 more sources