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Henipavirus Infections: Lessons from Animal Models [PDF]

Pathogens, 2013
The Henipavirus genus contains two highly lethal viruses, the Hendra and Nipah viruses and one, recently discovered, apparently nonpathogenic member; Cedar virus.
Kévin P. Dhondt, Branka Horvat
doaj   +8 more sources

Distinct Cell Transcriptomic Landscapes Upon Henipavirus Infections [PDF]

Frontiers in Microbiology, 2020
Hendra virus (HeV) and Cedar virus (CedV) are henipaviruses, which fall into the Paramyxoviridae family of single-stranded, negative-sense RNA viruses. HeV is classified as a Biosafety Level-4 (BSL-4) agent, as it is highly pathogenic and is often fatal ...
Mingyue Chen, Mingyue Chen, Mingyue Chen, Mary Tachedjian, Glenn A. Marsh, Jie Cui, Jie Cui, Lin-Fa Wang, Lin-Fa Wang   +8 more
doaj   +7 more sources

Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains. [PDF]

PLoS Neglected Tropical Diseases, 2018
Henipavirus infection causes severe respiratory and neurological disease in humans that can be fatal. To characterize the pathogenic mechanisms of henipavirus infection in vivo, we performed experimental infections in ferrets followed by genome-wide gene
Alberto J Leon, Viktoriya Borisevich, Nahal Boroumand, Robert Seymour, Rebecca Nusbaum, Olivier Escaffre, Luoling Xu, David J Kelvin, Barry Rockx   +8 more
doaj   +6 more sources

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection.

PLoS Pathogens, 2016
Hendra and Nipah viruses (genus Henipavirus, family Paramyxoviridae) are highly pathogenic bat-borne viruses. The need for high biocontainment when studying henipaviruses has hindered the development of therapeutics and knowledge of the viral infection ...
Celine Deffrasnes, Glenn A Marsh, Chwan Hong Foo, Christina L Rootes, Cathryn M Gould, Julian Grusovin, Paul Monaghan, Michael K Lo, S Mark Tompkins, Timothy E Adams, John W Lowenthal, Kaylene J Simpson, Cameron R Stewart, Andrew G D Bean, Lin-Fa Wang   +14 more
doaj   +5 more sources

Hendra virus: research progress on a bat-borne threat lurking at the human-animal interface [PDF]

Frontiers in Veterinary Science
Hendra virus (HeV) is a highly lethal zoonotic henipavirus that has caused recurrent cross-species spillover events in Australia since 1994. Its capacity for cross-species spillover, together with its tropism for vascular endothelial and neural tissues ...
Yanqin Duan, Yanqin Duan, Menghan Xu, Menghan Xu, Xuan Huang, Xuan Huang, Qi Liu, Qi Liu   +7 more
doaj   +2 more sources

Sequence-encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members. [PDF]

Protein Sci
Abstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Sawdekar H, Mignon J, Gondelaud F, Walimbe A, Mukhopadhyay S, Chamieh J, Longhi S.   +6 more
europepmc   +2 more sources

Henipavirus RNA in African bats. [PDF]

PLoS ONE, 2009
BackgroundHenipaviruses (Hendra and Nipah virus) are highly pathogenic members of the family Paramyxoviridae. Fruit-eating bats of the Pteropus genus have been suggested as their natural reservoir.
Jan Felix Drexler, Victor Max Corman, Florian Gloza-Rausch, Antje Seebens, Augustina Annan, Anne Ipsen, Thomas Kruppa, Marcel A Müller, Elisabeth K V Kalko, Yaw Adu-Sarkodie, Samuel Oppong, Christian Drosten   +11 more
doaj   +3 more sources

Henipavirus in Northern Short-Tailed Shrew, Alabama, USA [PDF]

Emerging Infectious Diseases
RNA metagenomic analysis of tissues from 4 wild-caught northern short-tailed shrews in Alabama, USA, revealed a novel henipavirus (family Paramyxoviridae).
Rhys H. Parry, KayLene Y.H. Yamada, Wendy R. Hood, Yang Zhao, Jinlong Y. Lu, Andrei Seluanov, Vera Gorbunova, Naphak Modhiran, Daniel Watterson, Ariel Isaacs   +9 more
doaj   +2 more sources

Indirect ELISA based on Hendra and Nipah virus proteins for the detection of henipavirus specific antibodies in pigs. [PDF]

PLoS ONE, 2018
Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus in the family Paramyxoviridae. Henipavirus infections were first reported in the 1990's causing severe and often fatal outbreaks in domestic animals and humans in Southeast Asia and
Kerstin Fischer, Sandra Diederich, Greg Smith, Sven Reiche, Vinicius Pinho Dos Reis, Eileen Stroh, Martin H Groschup, Hana M Weingartl, Anne Balkema-Buschmann   +8 more
doaj   +3 more sources

Serological and molecular analysis of henipavirus infections in synanthropic fruit bat and rodent populations in the Centre and North regions of Cameroon (2018–2020) [PDF]

BMC Veterinary Research
Background Bats and rodents have been identified as reservoirs for several highly pathogenic and zoonotic viruses including henipaviruses, a genus within the Paramyxoviridae family.
Cyrille Mbanwi Mbu’u, Pierre Gontao, Abel Wade, Maren Penning, Balal Sadeghi, Aristid Ekollo Mbange, Matthew LeBreton, Sylvain Leroy Sado Kamdem, Franziska Stoek, Martin Hermann Groschup, Wilfred Fon Mbacham, Anne Balkema-Buschmann   +11 more
doaj   +2 more sources