Results 31 to 40 of about 3,826 (162)

Immunopathogenesis of Nipah Virus Infection and Associated Immune Responses

Immuno, 2023
Pandemics in the last two centuries have been initiated by causal pathogens that include Severe Acute Coronavirus 2 (SARS-CoV-2) and Influenza (e.g., the H1N1 pandemic of 2009).
Brent Brown, Tanya Gravier, Ingo Fricke, Suhaila A. Al-Sheboul, Theodor-Nicolae Carp, Chiuan Yee Leow, Chinua Imarogbe, Javad Arabpour   +7 more
doaj   +1 more source

Reprogrammed Pteropus Bat Stem Cells as A Model to Study Host-Pathogen Interaction during Henipavirus Infection [PDF]

Microorganisms, 2021
Bats are natural hosts for numerous zoonotic viruses, including henipaviruses, which are highly pathogenic for humans, livestock, and other mammals but do not induce clinical disease in bats. Pteropus bats are identified as a reservoir of henipaviruses and the source of transmission of the infection to humans over the past 20 years.
Aurine, Noémie, Baquerre, Camille, Gaudino, Maria, Jean, Christian, Dumont, Claire, Rival-Gervier, Sylvie, Kress, Clémence, Horvat, Branka, Pain, Bertrand   +8 more
openaire   +4 more sources

Computational Approaches for Structure-Based Molecular Characterization and Functional Annotation of the Fusion Protein of Nipah henipavirus

Chemistry Proceedings, 2022
Throughout history, viral epidemics of varying frequency and intensity have been responsible for inducing panic and causing widespread damage. The Nipah virus has one of the highest rates of fatalities of any infectious disease in the world.
Abu Saim Mohammad Saikat, Ranjit Chandra Das, Madhab Chandra Das   +2 more
doaj   +1 more source

Cedar virus biology and its applications as a surrogate for highly pathogenic henipaviruses

Cell Insight
Nipah Virus (NiV) and Hendra Virus (HeV), are the prototype species of the genus Henipavirus and are highly pathogenic agents capable of causing fatal diseases in both animals and humans.
Ahmad Jawad Sabir, Lijun Rong, Christopher C. Broder, Moushimi Amaya   +3 more
doaj   +1 more source

Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundIn the last couple of years, viral infections have been leading the globe, considered one of the most widespread and extremely damaging health problems and one of the leading causes of mortality in the modern period.
Shopnil Akash, Arafat Hossain, Md. Sarowar Hossain, Md. Mominur Rahman, Mohammad Z. Ahmed, Nemat Ali, Martin Valis, Kamil Kuca, Kamil Kuca, Rohit Sharma   +9 more
doaj   +1 more source

Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection [PDF]

The Journal of Infectious Diseases, 2012
Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are ...
Dhondt, Kévin P, Mathieu, Cyrille, Chalons, Marie, Reynaud, Joséphine M, Vallve, Audrey, Raoul, Hervé, Horvat, Branka   +6 more
openaire   +4 more sources

Unveiling emerging threats: Langya and Mojiang—A dance with unfamiliar foes

Infectious Diseases & Immunity
. Langya henipavirus (LayV) and Mojiang henipavirus (MojV) are emerging zoonotic pathogens that were first identified in China in 2018 and 2012 respectively, and are classified within the Henipavirus genus.
Snehasis Nayak, Haijuan Wang
doaj   +1 more source

Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models

Viruses, 2022
Nipah henipavirus (NiV) and Hendra henipavirus (HeV) are zoonotic emerging paramyxoviruses causing severe disease outbreaks in humans and livestock, mostly in Australia, India, Malaysia, Singapore and Bangladesh. Both are bat-borne viruses and in humans, their mortality rates can reach 60% in the case of HeV and 92% for NiV, thus being two of the ...
Philip Lawrence, Beatriz Escudero-Pérez
openaire   +3 more sources

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

Interferon Signaling Remains Functional during Henipavirus Infection of Human Cell Lines [PDF]

Journal of Virology, 2011
ABSTRACT Henipaviruses encode several proteins from the P gene, of which V and W have been demonstrated by gene-based transfection studies to antagonize the innate immune response, blocking both type I interferon production and signaling. This study examines the effects of henipavirus infection on the innate immune response in human cell ...
Elena R, Virtue, Glenn A, Marsh, Lin-Fa, Wang   +2 more
openaire   +2 more sources