Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein [PDF]
Abstract Background The recent emergence of four new members of the paramyxovirus family has heightened the awareness of and re-energized research on new and emerging diseases. In particular, the high mortality and person to person transmission associated with the most recent Nipah virus outbreaks, as well as the very
Eaton Bryan T +5 more
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This study explores socioeconomic and health‐related aspects of a bat‐hunter community in Bangladesh, focusing on their unique cultural practices and the associated risks of bat‐borne infections. The hunter community predominantly engages in day labor and seasonal bat hunting as supplementary income.
A. K. M. Dawlat Khan, Hannah Wesley
wiley +1 more source
The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import [PDF]
Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host’s innate immune response. The W protein is one of four products encoded from the P gene and binds a number of host proteins to regulate signalling pathways.
Sofiya Tsimbalyuk +5 more
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The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response. [PDF]
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system.
Preeti Bharaj +9 more
doaj +1 more source
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang +19 more
wiley +1 more source
HenipavirusInfection in Fruit Bats (Pteropus giganteus), India
(Uploaded by Plazi for the Bat Literature Project) We tested 41 bats for antibodies against Nipah and Hendra viruses to determine whether henipaviruses circulate in pteropid fruit bats (Pteropus giganteus) in northern India. Twenty bats were seropositive for Nipah virus, which suggests circulation in this species, thereby extending the known ...
Epstein, Jonathan H. +7 more
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Integrating host condition into spatiotemporal multiscale models improves virus shedding predictions
Understanding where and when pathogens occur in the environment has implications for reservoir population health and infection risk. In reservoir hosts, infection status and pathogen shedding are affected by processes interacting across different scales: from landscape features affecting host location and transmission to within‐host processes affecting
Andrew M. Kramer +9 more
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Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot
Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz +2 more
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Zoonotic paramyxoviruses. Genus Henipavirus
Over the last two decades, data has been accumulated for zoonotic paramyxoviruses, also affecting human pathology. Of greatest importance are the two species of genus Henipavirus of family Paramyxoviridae – Hendra virus (HeV) and Nipah virus (NiV), that ...
Kostadinova, Tsvetelina; TRS Medical Laboratory Assistant, Medical College,Medical University of Varna +2 more
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Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren +19 more
wiley +1 more source

