Results 61 to 70 of about 3,863 (179)
Recent developments in experimental animal models ofHenipavirusinfection [PDF]
Pathogens and Disease, 2014 Hendra (HeV) and Nipah (NiV) viruses (genus Henipavirus (HNV; family Paramyxoviridae) are emerging zoonotic agents that can cause severe respiratory distress and acute encephalitis in humans. Given the lack of effective therapeutics and vaccines for human use, these viruses are considered as public health concerns. Several experimental animal models of
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The Journal of Clinical Investigation, 2023 The emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could spark another pandemic, most ...
Courtney Woolsey +12 more
doaj +1 more source
Land Use Change and Infectious Disease Emergence
Reviews of Geophysics, Volume 63, Issue 2, June 2025.Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli +6 more
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Protein Science, Volume 34, Issue 4, April 2025.Abstract The Hendra (HeV) and Nipah (NiV) viruses are high‐priority, biosafety level‐4 pathogens that cause fatal neurological and respiratory disease. Their P gene encodes not only the P protein, an essential polymerase cofactor, but also the virulence factors V and W.
Frank Gondelaud +4 more
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Protein Science, Volume 34, Issue 3, March 2025.Abstract Hendra virus (HeV) is a biosafety level 4 human pathogen belonging to the Henipavirus genus within the Paramyxoviridae family. In HeV, the phosphoprotein‐encoding gene also drives the synthesis of the V and W proteins that are two major players in the host innate immune response evasion.
Frank Gondelaud +8 more
wiley +1 more source
Characterization of functional human antibodies targeting henipavirus and flavivirus glycoproteins
, 2021 The henipaviruses Hendra (HeV) and Nipah (NiV), and the flavivirus yellow fever (YFV), pose massive global public health threats. No small molecule or antibody-based countermeasures are available to treat humans infected by HeV, NiV, or YFV, and major ...
Doyle, Michael Patrick
core
In silico Drug Discovery of Novel Small Lead Compounds Targeting Nipah Virus Attachment Glycoprotein
Journal of Integrated Health Sciences, 2018 Introduction: Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans.
Ashish P. Shah +3 more
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Reviews in Medical Virology, Volume 35, Issue 2, March 2025.ABSTRACT As Nipah virus (NiV) infection is characterised by a possible pandemic risk, being currently limited to a small but deadly belt, the attention of other countries is essential. It has often been pointed out that NiV is an under‐researched virus with a high‐risk potential. This study aimed to show the global research history and status quo based
Doris Klingelhöfer +4 more
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The FEBS Journal, Volume 292, Issue 3, Page 556-581, February 2025.The W proteins of Nipah and Hendra viruses exhibit fibrillation abilities in vitro, which have been attributed to the intrinsically disordered N‐terminal domain (NTD). Our research shows that the C‐terminal domain (CTD) of both viruses is intrinsically disordered and non‐fibrillogenic.
Giulia Pesce +5 more
wiley +1 more source
Проблемы особо опасных инфекций, 2018 Chiroptera is one of the largest in numbers orders of mammals which can take on the role of natural host and vector of various viruses, bacteria, and pathogenic fungi.
A. M. Porshakov +3 more
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