Results 81 to 90 of about 3,863 (179)

A Functional Genomics Approach to Henipavirus Research: The Role of Nuclear Proteins, MicroRNAs and Immune Regulators in Infection and Disease [PDF]

, 2017
Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are zoonotic RNA viruses that cause lethal disease in humans and are designated as Biosafety Level 4 (BSL4) agents. Moreover, henipaviruses belong to the same group of viruses that cause disease more commonly in humans such as measles, mumps and respiratory syncytial virus. Due to the
Stewart, CR, Deffrasnes, C, Foo, CH, Bean, AGD, Wang, L-F   +4 more
openaire   +3 more sources

Supplementary material from What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts

, 2019
Pathogen circulation among reservoir hosts is a precondition for zoonotic spillover. Unlike the acute, high morbidity infections typical in spillover hosts, infected reservoir hosts often exhibit low morbidity and mortality. Although it has been proposed
Romain Garnier (534823), Richard D. Suu-Ire (6876098), Olivier Restif (62644), Daniel J. Becker (795061), Alison J. Peel (133833), Louise Gibson (4911478), Raina K. Plowright (356000), Andrew A. Cunningham (117238), David T. S. Hayman (188106), Emma E. Glennon (6836753), James L. N. Wood (111001)   +10 more
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Interferon Production and Signaling Pathways Are Antagonized during Henipavirus Infection of Fruit Bat Cell Lines

PLoS ONE, 2011
(Uploaded by Plazi for the Bat Literature Project) Bats are natural reservoirs for a spectrum of infectious zoonotic diseases including the recently emerged henipaviruses (Hendra and Nipah viruses). Henipaviruses have been observed both naturally and experimentally to cause serious and often fatal disease in many different mammal species, including ...
Virtue, Elena R., Marsh, Glenn A., Baker, Michelle L., Wang, Lin-Fa, Tripp, Ralph   +4 more
openaire   +6 more sources

A highly effective ferritin-based divalent nanoparticle vaccine shields Syrian hamsters against lethal Nipah virus

Frontiers in Immunology
The Nipah virus (NiV), a highly deadly bat-borne paramyxovirus, poses a substantial threat due to recurrent outbreaks in specific regions, causing severe respiratory and neurological diseases with high morbidity. Two distinct strains, NiV-Malaysia (NiV-M)
Chunhong Yin, Chunhong Yin, Yan Feng Yao, Yan Feng Yao, Peipei Yang, Peipei Yang, Hang Liu, Hang Liu, Ge Gao, Ge Gao, Yun Peng, Yun Peng, Miaoyu Chen, Miaoyu Chen, Mingqing Lu, Mingqing Lu, Xuekai Zhang, Xuekai Zhang, Weiwei Guo, Weiwei Guo, Zihan Zhang, Zihan Zhang, Xue Hu, Xue Hu, Zhiming Yuan, Zhiming Yuan, Chao Shan, Chao Shan, Chao Shan, Chao Shan   +29 more
doaj   +1 more source

Henipavirus in Pteropus vampyrus Bats, Indonesia [PDF]

, 2006
The emergence of Nipah virus (NiV) in Malaysia in 1999 resulted in 265 known human infections (105 fatal), widespread infection in pigs (with >1 million culled to control the outbreak), and the collapse of the Malaysian pig export market.
Sendow, I., Curran, J., Darminto, ., Greer Meehan, Daniels, P., Buick, T., Peter Daniels, John Curran, Chris Morrissy, Field, H.E., Morrissy, C., Indrawati Sendow, Hume Ernest Field, Tim Buick, Meehan, G.   +14 more
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Spillover and emergence of bat-origin viral infections

, 2021
This thesis describes four years of research to quantify and characterise the system dynamics of bat-origin viral emergence events. Chapters 2–5 are comprised of four quantitative analyses: a compartmental model comparison of stochastic henipavirus ...

core   +1 more source

Henipaviruses at the Interface Between Bats, Livestock and Human Population in Africa: A Review

, 2019
Nipah virus (NiV) and Hendra virus (HeV) are closely related members within the genus Henipavirus, family Paramyxoviridae, for which fruit bats serve as the reservoir.
Sado Kamdem, Sylvain Leroy, Mbacham, Wilfred Fon, Groschup, Martin H., Wade, Abel, Fischer, Kerstin, Gontao, Pierre, Nlôga, Alexandre Michel Njan, Balkema-Buschmann, Anne, Mbu'u, Cyrille Mbanwi   +8 more
core   +1 more source

Unravelling the mystery of Nipah virus: from virus to therapeutics: current insights and future frontiers

Bulletin of the National Research Centre
Background Nipah virus (NiV) is a high-risk zoonotic infection that results in severe respiratory and neurological disease, with case fatality rates typically exceeding 70%. Driven by reservoir-host spillover and intermittent human-to-human transmission,
Jignesh Bhate, Rakesh Jain, Arun Vivek Jayabalan   +2 more
doaj   +1 more source

Novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle

Emerging Microbes and Infections
Nipah virus (NiV), a highly pathogenic Henipavirus in humans, has been responsible for annual outbreaks in recent years. Experiments involving live NiV are highly restricted to biosafety level 4 (BSL-4) laboratories, which impedes NiV research.
Yulong Wang, Linjin Fan, Pengfei Ye, Zequn Wang, Chudan Liang, Quan Liu, Xiaofeng Yang, Zhenyu Long, Wendi Shi, Yuandong Zhou, Jingyan Lin, Huijun Yan, Hongxin Huang, Linna Liu, Jun Qian   +14 more
doaj   +1 more source

Data from: What's stirring in the reservoir? modelling mechanisms of henipavirus circulation in fruit bat hosts

, 2019
Pathogen circulation among reservoir hosts is a precondition for zoonotic spillover. Unlike the acute, high morbidity infections typical in spillover hosts, infected reservoir hosts often exhibit low morbidity and mortality. Although it has been proposed
Becker, Daniel J., Garnier, Romain, Gibson, Louise, Plowright, Raina K., Restif, Olivier, Glennon, Emma E., Peel, Alison J., Cunningham, Andrew A., Suu-Ire, Richard D., Hayman, David T. S., Wood, James L. N.   +10 more
core   +1 more source