Results 1 to 10 of about 49,161 (205)

Cefepime and New Cefepime/Beta-Lactamase Inhibitor Combination for the Treatment of Gram-Negative Bacteria: Chemical Structure and Mechanism of Action, Microbiological Target, Clinical Use and PK/PD Characteristics [PDF]

Pharmaceuticals
The global spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, presents a significant public ...
Davide Carcione, Gioconda Brigante, Antonella Carducci, Jari Intra, Simone Ambretti, Floriana Campanile, Gabriele Arcari, Nicasio Mancini, Dario Cattaneo, Floriana Gona, Mariagrazia Perilli, Alessandra Piccirilli, Nicholas Geremia, Verena Zerbato, Stefano Di Bella, Giovanna Maria Nicolò, Luigi Principe   +16 more
doaj   +2 more sources

Efficacy of Cefepime and Vancomycin in Prevention of Dacron and ePTFE Vascular Grafts Infected with Staphylococcus aureus: A Rat Subcutaneous Model [PDF]

Iranian Journal of Veterinary Surgery, 2021
The objective of the present study was to evaluate systemic and local effects of cefepime alone and/or in combination with vancomycin in the prevention of experimentally implanted Dacron and ePTFE vascular grafts infected with Staphylococcus aureus in ...
Parya Naserzadeh, Saeed Azizi, Amir Tukmachi   +2 more
doaj   +1 more source

Pharmacokinetics and Pharmacodynamics of Cefepime in Adults with Hematological Malignancies and Febrile Neutropenia after Chemotherapy

Antibiotics, 2021
Patients with chemotherapy-induced febrile neutropenia (CIFN) may have changes in the pharmacokinetics (PK) compared to patients without malignancies or neutropenia.
José C. Álvarez, Sonia I. Cuervo, Edelberto Silva, Jorge A. Díaz, Lorena L. Jiménez, Daniel S. Parra, Julio C. Gómez, Ricardo Sánchez, Jorge A. Cortés   +8 more
doaj   +1 more source

Neurotoxicity by Cefepime: Case-Control Study [PDF]

Journal of Neurocritical Care, 2014
Background: Cefepime is a fourth-generation cephalosporin widely used for empiric treatment of severe infections. Neurotoxicity by cefepime have been reported due to γ-aminobutyric acid A receptor inhibition or other mechanisms. The aim of this study was
Joong Koo Kang, Soon Bae Kim
doaj   +1 more source

Design of an Experimental Study for the Simultaneous Determination of Cefepime, Piperacillin and Tazobactam Using Micellar Organic Solvent-Free HPLC

Separations, 2022
Application of Sustainable analytical chemistry concepts has become crucial in order to remove the environmentally harmful impacts originating from the routine use of analytical techniques.
Hani M. Hafez, Sami El Deeb, Esraa Abd Alkareem Naji, Zahraa Ali Aziz, Amaal Sajid Mahmood, Nooralhuda Ibrahim Khalil, Adel Ehab Ibrahim   +6 more
doaj   +1 more source

Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam

mBio, 2023
Multi-drug resistant (MDR) Pseudomonas aeruginosa harbor a complex array of β-lactamases and non-enzymatic resistance mechanisms. In this study, the activity of a β-lactam/β-lactam-enhancer, cefepime/zidebactam, and novel β-lactam/β-lactamase inhibitor ...
Andrea M. Hujer, Steven H. Marshall, Andrew R. Mack, Kristine M. Hujer, Yamuna Devi Bakthavatchalam, Kushal Umarkar, Snehal R. Palwe, Swapna Takalkar, Prashant R. Joshi, Rahul Shrivastava, Hariharan Periasamy, Sachin S. Bhagwat, Mahesh V. Patel, Balaji Veeraraghavan, Robert A. Bonomo   +14 more
doaj   +1 more source

Use of Novel Antibiograms to Determine the Need for Earlier Susceptibility Testing and Administration for New β-Lactam/β-Lactamase Inhibitors in the United States

Antibiotics, 2022
Antimicrobial resistance is a global public health threat, and gram-negative bacteria, such as Enterobacterales and Pseudomonas aeruginosa, are particularly problematic with difficult-to-treat resistance phenotypes.
Kenneth P. Klinker, Levita K. Hidayat, Eric Wenzler, Joan-Miquel Balada-Llasat, Mary Motyl, C. Andrew DeRyke, Karri A. Bauer   +6 more
doaj   +1 more source

Susceptibility of HEK293 and RPTEC Cell Lines to Nephrotoxic Effects of Cefuroxime and Cefepime: A Comparative Study

Безопасность и риск фармакотерапии, 2023
Researchers need to identify the nephrotoxic properties of medicinal products both during preclinical development and when exploring options to optimise pharmacotherapy.
V. A. Evteev, I. S. Semenova, N. D. Bunyatyan, A. B. Prokofiev   +3 more
doaj   +1 more source

Continuous Infusion of High Doses of Cefepime in Intensive Care Unit: Assessment of Steady-State Plasma Level and Incidence on Neurotoxicity

Antibiotics, 2022
Continuous infusion (CI) with high doses of cefepime is recommended in the empirical antimicrobial regimen of critically ill patients with suspected Gram-negative sepsis.
Vanessa Jean-Michel, Corentin Homey, Patrick Devos, Pierre-Yves Delannoy, Nicolas Boussekey, Thomas Caulier, Olivier Leroy, Hugues Georges   +7 more
doaj   +1 more source

Cephalosporins’ Cross-Reactivity and the High Degree of Required Knowledge. Case Report and Review of the Literature

Antibiotics, 2020
Antibiotic cross-reactivity represents a phenomenon of considerable interest as well as antibiotic resistance. Immediate reactions to cephalosporins are reported in the literature with a prevalence of only 1–3% of the population, while anaphylactic ...
Stefano D’Errico, Paola Frati, Martina Zanon, Eleonora Valentinuz, Federico Manetti, Matteo Scopetti, Alessandro Santurro, Vittorio Fineschi   +7 more
doaj   +1 more source