Results 21 to 30 of about 3,690 (153)

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, EarlyView.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources

An Overview of Cefiderocol’s Therapeutic Potential and Underlying Resistance Mechanisms

Life, 2023
Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat (DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas aeruginosa, CR Acinetobacter baumannii, and CR- and third-generation-cephalosporins-
Sara Domingues, Tiago Lima, Maria José Saavedra, Gabriela Jorge Da Silva   +3 more
doaj   +1 more source

Clinical Outcome of Cefiderocol for Infections with Carbapenem-Resistant Organisms

Antibiotics, 2023
Cefiderocol is a novel cephalosporin recently approved by the FDA to aid clinicians in the fight against multidrug-resistant (including carbapenem-resistant) gram-negative organisms.
Monirul I. Sajib, Melinda Monteforte, Roderick Go   +2 more
doaj   +1 more source

Population Analysis of Escherichia coli Sequence Type 361 and Reduced Cefiderocol Susceptibility, France

Emerging Infectious Diseases, 2023
Cefiderocol resistance is increasingly reported in New Delhi metallo-β-lactamase–producing Enterobacterales. Genomic and phenotypic analysis of Escherichia coli sequence type 361, a primary clone causing carbapenemase spread in France, revealed ...
Agnès B. Jousset, Laura Bouabdallah, Aurélien Birer, Isabelle Rosinski-Chupin, Jean-François Mariet, Saoussen Oueslati, Cécile Emeraud, Delphine Girlich, Philippe Glaser, Thierry Naas, Rémy A. Bonnin, Laurent Dortet   +11 more
doaj   +1 more source

In Vitro Activities and Inoculum Effects of Cefiderocol and Aztreonam-Avibactam against Metallo-β-Lactamase-Producing Enterobacteriaceae

Microbiology Spectrum, 2023
Cefiderocol and aztreonam-avibactam (ATM-AVI) both had activity against carbapenem-resistant Gram-negative bacilli, including those that produce metallo-β-lactamases (MBLs).
Yu-Shan Huang, Pao-Yu Chen, Pei-Chun Chou, Jann-Tay Wang   +3 more
doaj   +1 more source

Reduce susceptibility to cefiderocol in gram negative bacteria in children: Is hope already lost before it’s even arrived?

Journal of Infection and Public Health
Background: In last years the diffusion of carbapenem resistance in Gram-negative bacteria (CR-GNB) is increasing worldwide, mainly due to the expression of carbapenemases.
Chiara Russo, Alessio Mesini, Marcello Mariani, Elisa Tavella, Claudia Sette, Elisabetta Ugolotti, Claudia Bartalucci, Candida Palmero, Roberto Bandettini, Elio Castagnola   +9 more
doaj   +1 more source

In-Vitro Efficacy of Cefiderocol in Carbapenem-Non-Susceptible Gram-Negative Bacilli of Different Genotypes in Sub-Region of North Rhine Westphalia, Germany

Pathogens, 2021
In the last two decades, the worldwide dissemination of multidrug-resistant Gram-negative bacteria (MDR-GNB) has continued. Therapy options for such infections caused by MDR-GNB remain scarce, and only few new antimicrobial agents have been granted ...
Beniam Ghebremedhin, Parviz Ahmad-Nejad
doaj   +1 more source

Synergistic Activity of Cefiderocol in Combination with Avibactam, Sulbactam or Tazobactam against Carbapenem-Resistant Gram-Negative Bacteria

Cells
We investigated the activity of cefiderocol/β-lactamase inhibitor combinations against clinical strains with different susceptibility profiles to cefiderocol to explore the potentiality of antibiotic combinations as a strategy to contain the major public
Russell E. Lewis, Marta Palombo, Erica Diani, Benedetta Secci, Davide Gibellini, Paolo Gaibani   +5 more
doaj   +1 more source

Proteomic and Transcriptomic Analyses Indicate Reduced Biofilm-Forming Abilities in Cefiderocol-Resistant Klebsiella pneumoniae

Frontiers in Microbiology, 2022
The advent of cefiderocol provides hope for the clinical treatment of multi-drug resistant gram-negative bacteria (GNB), especially those with carbapenem resistance.
Jinfeng Bao, Jinfeng Bao, Jinfeng Bao, Lu Xie, Yating Ma, Ran An, Bing Gu, Bing Gu, Chengbin Wang   +8 more
doaj   +1 more source

Role of Cefiderocol in Multidrug-Resistant Gram-Negative Central Nervous System Infections: Real Life Experience and State-of-the-Art

Antibiotics
Cefiderocol is a new molecule effective against multidrug-resistant (MDR) Gram-negative pathogens. Currently, there is limited evidence regarding the use of cefiderocol in central nervous system (CNS) infections.
Alessio Sollima, Francesco Rossini, Paola Lanza, Carlo Pallotto, Marianna Meschiari, Ivan Gentile, Roberto Stellini, Angelica Lenzi, Alice Mulé, Francesca Castagna, Silvia Lorenzotti, Silvia Amadasi, Evelyn Van Hauwermeiren, Barbara Saccani, Benedetta Fumarola, Liana Signorini, Francesco Castelli, Alberto Matteelli   +17 more
doaj   +1 more source