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Genomic and Clinical Features Associated With Reduced Susceptibility to Cefiderocol and Cross-Resistance to β-Lactam/β-Lactamase Inhibitors in a Global Cohort of Pseudomonas aeruginosa

open access: hybrid
Stephanie L Egge   +12 more
openalex   +1 more source
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High prevalence of cefiderocol resistance in carbapenem-resistant Escherichia coli: A warning from multicenter clinical data in China

Journal of Infection
AIMS This study aimed to evaluate the in vitro efficacy of cefiderocol and other agents against carbapenem-resistant Escherichia coli (CREC) clinical isolates in China and to elucidate the genetic mechanisms underlying cefiderocol resistance. METHODS A
Junxin Zhou, Qianyi Chen, Ying Cui
exaly   +2 more sources

CefiderocolFinder: a tool for detecting genetic adaptations implicated in cefiderocol resistance.

open access: yesClinical Microbiology and Infection
OBJECTIVES Cefiderocol is a novel last-resort cephalosporin antimicrobial increasingly used for difficult-to-treat infections by multidrug-resistant microorganisms (MDRO), and is effective against carbapenem-resistant Enterobacterales and Pseudomonas ...
Bryan van den Brand   +57 more
semanticscholar   +5 more sources

Rapid cefiderocol NP test for detection of cefiderocol susceptibility/resistance in Enterobacterales

Journal of Antimicrobial Chemotherapy, 2022
Abstract Background Cefiderocol is among the latest generation of commercialized antibiotics against a large variety of MDR Gram-negative bacteria including carbapenem-resistant Enterobacterales and non-fermenters such as Pseudomonas aeruginosa and Acinetobacter baumannii.
Patrice Nordmann   +3 more
openaire   +2 more sources

Cefiderocol: Clinical application and emergence of resistance

Drug Resistance Updates
Antibacterial drug resistance of gram-negative bacteria (GNB) results in high morbidity and mortality of GNB infection, seriously threaten human health globally. Developing new antibiotics has become the critical need for dealing with drug-resistant bacterial infections.
Hong Du
exaly   +3 more sources

NDM-driven cefiderocol resistance: effect and therapeutic considerations.

The Lancet Infectious Diseases
Brenda A Warecki   +3 more
semanticscholar   +3 more sources

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