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Cefiderocol for Infections Caused by Multidrug-Resistant Gram-Negative Bacteria
Nursing for Women's Health, 2020In 2019, the U.S. Food and Drug Administration approved cefiderocol, a new treatment option for individuals with complicated urinary tract infections. Cefiderocol is a cephalosporin antibiotic indicated for use in adults 18 years or older who have minimal treatment options due to resistance for complicated urinary tract infections caused by Escherichia
Kendra Weaver +2 more
openaire +2 more sources
International Journal of Antimicrobial Agents
Cefiderocol is an ultimate antibiotic option for Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). While resistance often involves metallo-β-lactamases, mechanisms in KPC-producing strains are unclear. This study used in vitro evolution
Danni Pu +5 more
semanticscholar +1 more source
Cefiderocol is an ultimate antibiotic option for Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). While resistance often involves metallo-β-lactamases, mechanisms in KPC-producing strains are unclear. This study used in vitro evolution
Danni Pu +5 more
semanticscholar +1 more source
Clinical Microbiology and Infection
OBJECTIVES This study evaluated the in vitro activity of cefiderocol against clinical carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates in China prior to its clinical introduction, and investigated the mechanisms underlying resistance ...
Yang-hua Xiao +8 more
semanticscholar +1 more source
OBJECTIVES This study evaluated the in vitro activity of cefiderocol against clinical carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates in China prior to its clinical introduction, and investigated the mechanisms underlying resistance ...
Yang-hua Xiao +8 more
semanticscholar +1 more source
Expert Opinion on Drug Metabolism & Toxicology, 2022
Cefiderocol is a siderophore cephalosporin antibiotic and first of its kind approved by the Food and Drug Administration for the treatment of complicated urinary tract infections (cUTI) and hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) in patients 18 years or older caused by susceptible organisms.
Emily N. Drwiega +2 more
openaire +2 more sources
Cefiderocol is a siderophore cephalosporin antibiotic and first of its kind approved by the Food and Drug Administration for the treatment of complicated urinary tract infections (cUTI) and hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) in patients 18 years or older caused by susceptible organisms.
Emily N. Drwiega +2 more
openaire +2 more sources
Clinical Microbiology and Infection
OBJECTIVES Stenotrophomonas maltophilia (Sm) is responsible for infections among immunocompromised and hospitalized patients. Its genomic diversity led to the description of a large complex including numerous genogroups.
Céline Sakr +7 more
semanticscholar +1 more source
OBJECTIVES Stenotrophomonas maltophilia (Sm) is responsible for infections among immunocompromised and hospitalized patients. Its genomic diversity led to the description of a large complex including numerous genogroups.
Céline Sakr +7 more
semanticscholar +1 more source
International Journal of Antimicrobial Agents
Cefiderocol is a new siderophore-cephalosporin showing potent activity against Pseudomonas aeruginosa, including isolates showing extensively drug-resistant (XDR) or difficult-to-treat resistant (DTR) phenotypes. However, there is still a limited understanding of the potential resistance mechanisms.
Irène Gracia-Ahufinger +2 more
exaly +3 more sources
Cefiderocol is a new siderophore-cephalosporin showing potent activity against Pseudomonas aeruginosa, including isolates showing extensively drug-resistant (XDR) or difficult-to-treat resistant (DTR) phenotypes. However, there is still a limited understanding of the potential resistance mechanisms.
Irène Gracia-Ahufinger +2 more
exaly +3 more sources
Current Microbiology
The global spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly carbapenem- and colistin-resistant strains, represents a critical public health crisis with limited therapeutic options. Cefiderocol, a first-in-class siderophore cephalosporin, addresses this challenge through an innovative Trojan horse mechanism.
Mohammad Javad Roustaye Gourabi +6 more
openaire +2 more sources
The global spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly carbapenem- and colistin-resistant strains, represents a critical public health crisis with limited therapeutic options. Cefiderocol, a first-in-class siderophore cephalosporin, addresses this challenge through an innovative Trojan horse mechanism.
Mohammad Javad Roustaye Gourabi +6 more
openaire +2 more sources