Results 41 to 50 of about 3,471,294 (187)

In vivo development of cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii associated with the downregulation of a TonB-dependent siderophore receptor, PiuA. [PDF]

J Antimicrob Chemother
Multidrug-resistant Gram-negative bacteria are one of the major threats to human health, largely due to the dissemination of some high-risk successful multidrug-resistant clones.
Findlay J, Bianco G, Boattini M, Nordmann P.   +3 more
europepmc   +2 more sources

Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations

International Journal of Infectious Diseases
Cefiderocol, a siderophore-conjugated cephalosporine, is a promising drug used to treat infection with carbapenem-resistant gram-negative bacteria. Here, we report a case of pneumonia induced by multiple gram-negative pathogens, including a carbapenem ...
Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenaël Le Moal, Arnaud W. Thille, Olivier Barraud, Sandrine Marchand, Julien M. Buyck   +8 more
doaj   +2 more sources

Evolution of cefiderocol resistance in Stenotrophomonas maltophilia using in vitro serial passage techniques. [PDF]

JAC Antimicrob Resist, 2022
Objectives Cefiderocol is a siderophore cephalosporin active against MDR Gram-negatives including Stenotrophomonas maltophilia. Cefiderocol resistance remains uncommon and incompletely understood. We selected for cefiderocol-resistant S.
Werth BJ, Ashford NK, Penewit K, Waalkes A, Holmes EA, Bryan A, Salipante SJ.   +6 more
europepmc   +2 more sources

Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii. [PDF]

Antimicrob Agents Chemother, 2022
Cefiderocol is a novel siderophore cephalosporin that displays activity against Gram-negative bacteria. To establish cefiderocol susceptibility levels of Acinetobacter baumannii strains from China, we performed susceptibility testing and genomic analyses
Liu X, Lei T, Yang Y, Zhang L, Liu H, Leptihn S, Yu Y, Hua X.   +7 more
europepmc   +2 more sources

Genomic Insights of Two Acinetobacter Non-Baumannii Strains with Uncommon Mechanisms of Resistance Leading to Cefiderocol Resistance

Infection, Genetics and Evolution
The emergence of antimicrobial resistance in Acinetobacter species poses a significant clinical challenge, particularly in non-baumannii species, which are often overlooked in healthcare settings.
Usman Akhtar, Samyar Moheb, Carol Davies‐Sala, Joshua Gutierrez, Fernando Pasterán, Marisel R. Tuttobene, Tomás Subils, Chun Fu Cheng, Quentin Vallé, Rajnikant Sharma, Marcelo E. Tolmasky, Gauri G. Rao, Robert A. Bonomo, Germán M. Traglia, María Soledad Ramirez   +14 more
semanticscholar   +3 more sources

A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance. [PDF]

Antimicrob Agents Chemother
Carbapenem resistance due to metallo-β-lactamases (MBLs) such as the Verona integron-encoded metallo-β-lactamase (VIM) is particularly problematic due to the limited treatment options.
Freiberg JA, Tao L, Manuel C, Mike LA, Nelson GE, Harris BD, Mathers AJ, Talbot TR, Skaar EP, Humphries RM.   +9 more
europepmc   +2 more sources

Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance. [PDF]

Front Microbiol
Acinetobacter baumannii is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative ...
Morosi L, Golzato D, Bussini L, Guma H, Tordato F, Armanini F, Asif Z, Carella F, Morelli P, Bartoletti M, Da Rin G, Casari E, Martano G, Rescigno M, Segata N, Carloni S, Cento V.   +16 more
europepmc   +2 more sources

Combinatorial effects of a novel SHV-248 variant, NDM-5, and ompK35 deficiency drive high-level cefiderocol resistance in Klebsiella pneumoniae [PDF]

Microbiology Spectrum
Cefiderocol holds significant therapeutic value against metallo-β-lactamase-producing Enterobacterales. However, reduced susceptibility to cefiderocol in NDM-producing strains is increasingly observed.
Chuwen Zhao, Yuxuan Liu, Hanxu Hong, Yun Cao, Xinyue Dai, Qianbin Dai, DanDan Wei, Yang Liu   +7 more
doaj   +2 more sources

A Selective Culture Medium for Screening Cefiderocol Resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. [PDF]

J Clin Microbiol, 2023
Ibrahim A, Bouvier M, Sadek M, Decousser JW, Poirel L, Nordmann P.   +5 more
europepmc   +3 more sources

Global molecular epidemiology of the incomplete CirA protein related to cefiderocol resistance in Klebsiella pneumoniae : a genome-based study

Microbiology spectrum
CirA is an iron transporter comprising 657 amino acids in Klebsiella pneumoniae, and incomplete CirA alone leads to reduced susceptibility to cefiderocol. We performed a genome-based analysis to study the prevalence of incomplete CirA in K.
Haiyan Long, Yu Feng, Zhiyong Zong
openalex   +2 more sources