Results 51 to 60 of about 3,471,294 (187)

Cefiderocol resistance in a clinical ST11-KL64 hypervirulent Klebsiella pneumoniae isolate mediated by a novel CirA truncation and SHV-12 β-lactamase [PDF]

BMC Microbiology
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections have emerged as a major global public health threat. Cefiderocol is a novel siderophore-conjugated cephalosporin with potent activity to treat severe infections caused by CRKP.
Peiyao Zhou, Jiana Fu, Xiaoxia He, Haojin Gao, Chunyang Wu, Fangyou Yu, Ying Zhou   +6 more
doaj   +2 more sources

Cefiderocol in Combating Carbapenem-Resistant Acinetobacter baumannii: Action and Resistance

Biomedicines
Acinetobacter baumannii (A. baumannii) has emerged as a prominent multidrug-resistant (MDR) pathogen, significantly complicating treatment strategies due to its formidable resistance mechanisms, particularly against carbapenems.
Bahman Yousefi, Setayesh Kashanipoor, Payman Mazaheri, Farnaz Alibabaei, Ali Babaeizad, Shima Asli, Sina Mohammadi, Amir Hosein Gorgin, Tahereh Alipour, Valentyn Oksenych, Majid Eslami   +10 more
doaj   +4 more sources

Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance

Scientific Reports
Cefiderocol-resistant bacteria pose a growing concern in both clinical and environmental settings. This study investigates cefiderocol-resistant bacteria in wastewater from six German tertiary care hospitals.
Tim Erler, Laura Carlsen, Jennifer Dengler, Jens Andre Hammerl, Andreas J. Stroehlein, Marc Hoffmann, Johannes K. Knobloch, Christoph Lübbert, Cihan Papan, Thomas Schwanz, Janine Zweigner, Anurag Kumar Bari, Basil Britto Xavier, John W. A. Rossen, Nico T. Mutters, Mykhailo Savin   +15 more
doaj   +3 more sources

Cross-resistance to cefiderocol and ceftazidime–avibactam in KPC β-lactamase mutants and the inoculum effect

Clinical Microbiology and Infection, 2021
Claire Amaris Hobson, Hervé Jacquier, Melanie Magnan   +2 more
exaly   +2 more sources

Genomic analysis reveals multi-level resistance network linking oxidative stress pathway mutations to cefiderocol resistance and clonal evolution in <i>Klebsiella pneumoniae</i> from the United Arab Emirates. [PDF]

Front Cell Infect Microbiol
Daoud L, Collyns T, Ghazawi A, Al-Marzooq F.   +3 more
europepmc   +2 more sources

49 Bacterial siderophores drive cefiderocol resistance and crossprotection [PDF]

Journal of Cystic Fibrosis, 2023
A. Milesi Galdino, M. Vaillancourt, D. Celedonio, Peter Jorth   +3 more
openalex   +2 more sources

New mutations in genes associated with cefiderocol resistance in a clinical isolate of Pseudomonas aeruginosa [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
Objective. To assess the effects of chromosomal mutations on emergence of cefiderocol resistance among Pseudomonas aeruginosa clinical isolates. Materials and Methods.
Bocharova Yu.A., Savinova T.A., Mayansky N.A., Chebotar I.V.   +3 more
doaj   +1 more source

New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae [PDF]

Antimicrobial Agents and Chemotherapy, 2022
Dennis Nurjadi, Kaan Kocer, Sabrina Klein   +2 more
exaly   +2 more sources

Review of: "Evolution of β-lactamase mediated cefiderocol resistance" [PDF]

, 2022
Hélio S. Sader
openalex   +2 more sources

In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol [PDF]

The Journal of Antibiotics
AbstractCefiderocol, a novel siderophore cephalosporin, demonstrates promising in vitro activity against multidrug-resistant Gram-negative bacteria, including carbapenemase-producing strains. Nonetheless, only a few reports are available regarding the acquisition of resistance in clinical settings, primarily due to its recent usage. This study aimed to
Richard Kriz, Kathrin Spettel, Alina Pichler, Katharina Schefberger, Maria Sanz-Codina, Felix Lötsch, Nicole Harrison, Birgit Willinger, Markus Zeitlinger, Heinz Burgmann, Heimo Lagler   +10 more
openalex   +3 more sources