The impact of inoculum size on the activity of cefoperazone-sulbactam against multidrug resistant organisms [PDF]
Journal of Microbiology, Immunology and Infection, 2018 Objectives: This study aims to assess the in vitro activity of cefoperazone alone and different cefoperazone-sulbactam ratios against different inoculum sizes of multidrug resistant organisms.
Yin-Ching Chuang +2 more
exaly +4 more sources
Severe delayed coagulopathy caused by cefoperazone/sulbactam: A case report [PDF]
Journal of International Medical ResearchThis case report described a suspected severe coagulopathy attributed to cefoperazone/sulbactam, and this adverse reaction might be associated with the inhibition of the vitamin K cycle by cefoperazone/sulbactam, leading to vitamin K deficiency within ...
Siqin Sun +4 more
doaj +3 more sources
Comparative pharmacokinetics of cefoperazone following intravenous and intramuscular administration in goats [PDF]
International Journal of Veterinary Science and Medicine, 2015 The pharmacokinetic profile of cefoperazone was studied in goats following intravenous and intramuscular administration of 20 mg/kg body weight. Cefoperazone concentrations in serum were determined by microbiological assay technique using Escherichia ...
Taha Attia +4 more
exaly +4 more sources
Frontiers in Medicine, 2021 There has previously been a report of a patient developing haemolytic anaemia following exposure to cefoperazone. Another case has been reported involving the detection of cefoperazone-dependent antibodies in the absence of immune haemolytic anaemia.
Yuanjun Wu
exaly +3 more sources
Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect [PDF]
Annals of MedicineBackground Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeutic index and extensive interindividual pharmacokinetic variability complicate optimal dosing during the ...
Jinlin Guo +6 more
doaj +2 more sources
Evaluating the Risk of Coagulopathy in Cephalosporins with Different Side Chains: A Propensity Score–Weighted Study [PDF]
MedicinaBackground and Objectives: Cephalosporins containing N-hydroxyethyltetrazolethiol (HTT) or N-methylthiotetrazole (NMTT) side chains, such as flomoxef and cefoperazone, have been linked to coagulation abnormalities.
Chien-Hsiang Tai +2 more
doaj +2 more sources
Extreme and rapidly reversible prolongation of prothrombin time during cefoperazone/sulbactam therapy in a patient with gastrointestinal dysfunction and parenteral nutrition: a case report [PDF]
Frontiers in PharmacologyThis case report describes a suspected coagulation disorder induced by cefoperazone/sulbactam administered for anti-infective therapy. The coagulopathy may be associated with the inhibition of vitamin K synthesis and utilization caused by cefoperazone ...
Tian-Rui Gao +3 more
doaj +2 more sources
International Journal of Infectious Diseases, 2020 Objectives: To evaluate the antimicrobial activities of cefoperazone-sulbactam and comparator agents tested against a large collection of clinical isolates of Gram-negative organisms. Methods: A total of 19 545 Gram-negative organisms were collected from
Helio Sader +2 more
exaly +3 more sources
Perioperative antibiotic prophylaxis in surgery
Perioperative Medicine, 2021 Infectious complications in surgery occupy a significant place among the causes of death and increase in the cost of medical care for various pathologies.
Dmytro Dmytriiev +2 more
doaj +1 more source
Cefoperazone Induced Gastrointestinal Bleeding [PDF]
Journal of Clinical and Diagnostic Research, 2016 Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K ...
Goutham Reddy Katukuri +3 more
doaj +1 more source