Genomic Analysis of Third Generation Cephalosporin Resistant Escherichia coli from Dairy Cow Manure
The production of extended-spectrum β-lactamases (ESBLs) conferring resistance to new derivatives of β-lactams is a major public health threat if present in pathogenic Gram-negative bacteria. The objective of this study was to characterize ceftiofur (TIO)
Muhammad Attiq Rehman +7 more
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Multidrug resistance (MDR) plasmids drive the spread of antibiotic resistance between bacterial lineages. The immediate impact of MDR plasmid acquisition on fitness and cellular processes varies among bacterial lineages, but how the evolutionary ...
Laura Carrilero +4 more
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Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity [PDF]
This study explores the killing kinetics within 12 h of four oral third-generation cephalosporins against ten Streptococcus pneumoniae strains exhibiting cefotaxime minimum inhibitory concentrations (MICs) from 0.03 to 2 microg/ml.
Alou Cervera, Luis +9 more
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New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits [PDF]
Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in experimental pneumococcal meningitis. Cefotaxime penetrated only moderately into the cerebrospinal fluid of rabbits with meningitis, whereas cefpimizole,
Täuber, MG +4 more
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Population pharmacokinetics of cefotaxime in intensive care patients [PDF]
PURPOSE: To characterise the pharmacokinetics and associated variability of cefotaxime in adult intensive care unit (ICU) patients and to assess the impact of patient covariates.
Lipcsey, Miklós +5 more
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IDENTICAL ANTIMICROBIAL EFFECT OF CEFTRIAXONE AND CEFOTAXIME AMONG DIFFERENT BACTERIAL ISOLATES [PDF]
Background: This study aimed to screen the antimicrobial-resistant profile of these 3rd generation cephalosporins and to identify their similarity and interchangeability.
Khaled Abu El Aish +2 more
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Influence of the developmental state of valvular lesions on the antimicrobial activity of cefotaxime in experimental enterococcal infections [PDF]
Cefotaxime has little antimicrobial activity in vitro against most strains of enterococci, as measured by conventional MICs and MBCs. However, the MICs of cefotaxime against many enterococci are markedly reduced by the addition of serum to the test ...
Drake, TA +4 more
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The article provides information on the stability of the niosomal form of cefotaxime. Aliquots of the preparations were stored separately at (4 ± 2) ºС and (22 ± 2) ºС for 180 days.
V. N. Shakhova +3 more
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Molecular characterization and antibiotic resistance profile of ESBL-producing Escherichia coli isolated from healthy cow raw milk in smallholder dairy farms in Bangladesh [PDF]
Background and Aim: The emergence of antimicrobial-resistant bacteria, such as Escherichia coli in milk, is a serious public health concern as milk is considered a complete food and an important part of daily human diet worldwide, including in Bangladesh.
Azimun Nahar +6 more
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Neutropenia Associated with Cefotaxime [PDF]
Neutropenia is rarely associated with cephalosporins. We report a case of neutropenia associated with cefotaxime. A seven-year-old boy was admitted to the Chidoribashi Hospital with suspected septicemia. Cefotaxime 2 g/d was started.
Tomoji Ohsawa, Fumitaka Furukawa
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