Results 151 to 160 of about 11,837 (160)

Complex evolutionary trajectories in vivo of two novel KPC variants conferring ceftazidime-avibactam resistance.

International Journal of Antimicrobial Agents
More and more ceftazidime-avibactam resistant KPC-producing K. pneumoniae have been reported with its widespread use, and the detection rate of KPC variants has increased dramatically.
Chengkang Tang, S. Shen, Weiwei Yang, Qingyu Shi, Li Ding, Renru Han, D. Yin, Yan Guo, Demei Zhu, F. Hu   +9 more
semanticscholar   +1 more source

Sequential Treatment Failure With Aztreonam-Ceftazidime-Avibactam Followed by Cefiderocol Due to Preexisting and Acquired Mechanisms in a New Delhi Metallo-β-lactamase-Producing Escherichia coli Causing Fatal Bloodstream Infection.

Clinical Infectious Diseases
We report a fatal case of New Delhi metallo-β-lactamase (NDM)-producing Escherichia coli in a bacteremic patient with sequential failure of aztreonam plus ceftazidime-avibactam followed by cefiderocol.
Fiona Senchyna, K. Murugesan, William Rotunno, S. Nadimpalli, Stan Deresinski, Niaz Banaei   +5 more
semanticscholar   +1 more source

Mutant prevention concentrations, in vitro resistance evolution dynamics, and mechanisms of resistance to imipenem and imipenem/relebactam in carbapenem-susceptible Klebsiella pneumoniae isolates showing ceftazidime/avibactam resistance

Antimicrobial Agents and Chemotherapy
Klebsiella pneumoniae carbapenemase (KPC) variants selected during ceftazidime/avibactam treatment usually develop susceptibility to carbapenems and carbapenem/β-lactamase inhibitors, such as imipenem and imipenem/relebactam.
T. Blanco-Martín, Lucía González-Pinto, Pablo Aja-Macaya, Salud Rodríguez-Pallares, Lucía Sánchez-Peña, E. Gato, M.ª del Carmen Fernández-López, Michelle Outeda-García, Arianna Rodríguez-Coello, Rosa Pedraza-Merino, Isaac Alonso-García, J. C. Vázquez-Ucha, Luis Martínez-Martínez, J. Arca-Suárez, A. Beceiro, G. Bou   +15 more
semanticscholar   +1 more source

First report of KPC variants conferring ceftazidime-avibactam resistance in Colombia: introducing KPC-197

Microbiology spectrum
Resistance to ceftazidime-avibactam (CZA) due to Klebsiella pneumoniae carbapenemase (KPC) variants is increasing worldwide. We characterized two CZA-resistant clinical Klebsiella pneumoniae strains by antimicrobial susceptibility test, conjugation ...
Elsa De la Cadena, M. Mojica, Laura J. Rojas, Betsy E. Castro, J. C. García-Betancur, S. Marshall, Natalia Restrepo, Nancy Patricia Castro-Caro, Magalis Fonseca-Carrillo, C. Pallares, R. Bonomo, M. V. Villegas   +11 more
semanticscholar   +1 more source

Renal Function and Its Impact on the Concentration of Ceftazidime-Avibactam: A cross-sectional study.

International Journal of Antimicrobial Agents
OBJECTIVES This study measured the effect of renal function on the plasma concentrations of ceftazidime and avibactam in critically ill patients. We also sought to measure the concentration ratio of ceftazidime to avibactam.
S. Lanini, Simone Giuliano, Jacopo Angelini, Sara Ferin, Luca Martini, Massimo Baraldo, Stella Cossettini, Jason Roberts, Carlo Tascini   +8 more
semanticscholar   +1 more source

In vivo emergence of cefiderocol and ceftazidime/avibactam cross-resistance in KPC-producing Klebsiella pneumoniae following ceftazidime/avibactam -based therapies.

Diagnostic microbiology and infectious disease
We described the emergence of ceftazidime/avibactam and cefiderocol cross-resistance in patients with KPC-producing Klebsiella pneumoniae infections. All strains with ceftazidime/avibactam and cefiderocol cross-resistance showed point mutations on KPC Ω ...
Stefano Amadesi, Alberto Amedeo, M. Rinaldi, Marta Palombo, M. Giannella, P. Gaibani   +5 more
semanticscholar   +1 more source

Identification of blaKPC-90 in Klebsiella pneumoniae associated with ceftazidime-avibactam resistance and the translocation & truncation of resistant genes mediated by IS26.

International Journal of Antimicrobial Agents
In this study, we discovered blaKPC-90 in ceftazidime-avibactam resistant clinical isolates of K. pneumoniae from a patient with multiple comorbidities.
Weiwei Yang, Heping Xu, Yuanxun Zhao, Wannan Chen, Xiaobo Ma, F. Hu   +5 more
semanticscholar   +1 more source

Evolution of ceftazidime/avibactam resistance and plasmid dynamics in OXA-48-producing Klebsiella spp. during long-term patient colonization

European Journal of Clinical Microbiology and Infectious Diseases
Salud Rodríguez-Pallares, M. A. Mateo-Vargas, M. Rodríguez-Iglesias, J. Arca-Suárez, Fátima Galán-Sánchez   +4 more
semanticscholar   +1 more source

Safety evaluation of ceftazidime/avibactam based on FAERS database

Infection
Xiuhong Zhang, Ying Jiang, Yating Guo, Wenbo Zhou, Weizhen Qiao, Haohao Zhu, Zhigang Qi   +6 more
semanticscholar   +1 more source

Clinical impact of ceftazidime/avibactam on the treatment of suspected or proven infections in a large cohort of patients with haematological malignancies: a multicentre observational real-world study.

Journal of Antimicrobial Chemotherapy
Mario Tumbarello, G. Giuliano, Marianna Criscuolo, M. D. del Principe, C. Papayannidis, N. Fracchiolla, M. Dargenio, Mariagiovanna Cefalo, G. Nadali, A. Candoni, C. Buquicchio, Francesco Marchesi, Marco Picardi, Federica Lessi, Monica Piedimonte, L. Prezioso, M. Piccini, C. Cattaneo, A. Busca, Sara Brunetti, E. Buzzatti, A. Dedola, M. Sciumè, N. Di Renzo, L. Cesini, Alessandra Vatteroni, F. Raffaelli, Livio Pagano   +27 more
semanticscholar   +1 more source