Results 81 to 90 of about 21,829 (156)

Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers [PDF]

, 2018
Objectives: Our objective was to develop population pharmacokinetic (PK) models for ceftazidime and avibactam in the plasma and epithelial lining fluid (ELF) of healthy volunteers and to compare ELF concentrations to plasma PK/pharmacodynamic (PD ...
Dimelow, R, Newell, P, MacPherson, M, Das, S, Wright, JG   +4 more
core   +1 more source

Evaluation of a simple method for testing aztreonam and ceftazidime-avibactam synergy in New Delhi metallo-beta-lactamase producing Enterobacterales.

PLoS ONE
NDM-producing carbapenem-resistant bacterial infections became a challenge for clinicians. Combination therapy of aztreonam and ceftazidime-avibactam is a prudent choice for these infections.
Salman Khan, Arghya Das, Deepali Vashisth, Anwita Mishra, Ashima Jain Vidyarthi, Raghav Gupta, Nazneen Nahar Begam, Babita Kataria, Sushma Bhatnagar   +8 more
doaj   +1 more source

Therapeutic drug monitoring of ceftazidime/avibactam: why one leg is not enough to run

Background: Therapeutic drug monitoring (TDM) is becoming an increasingly recommended approach for assessing optimal pharmacokinetic/pharmacodynamic (PK/PD) target attainment of ceftazidime/avibactam.
Gatti, Milo, Viale, Pierluigi, Pea, Federico   +2 more
core   +1 more source

Ceftazidime-avibactam/aztreonam combination synergy against carbapenem-resistant Gram-negative isolates: In vitro study

Current Medicine Research and Practice
Background: The ceftazidime-avibactam combination is able to inhibit ESBLs, AmpCs and Class A carbapenemases and has been recommended for the treatment of complicated UTIs and ventilator-associated bacterial pneumonia.
Reena Rajan, A V Raghavendra Rao, Mathavi Suresh Kumar   +2 more
doaj   +1 more source

Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam ...
Mateo-Vargas, María Alejandra, Rodríguez-Pallares, Salud, Galán-Sánchez, Fátima, Arca-Suárez, Jorge, López Cerero, Lorena, Rodríguez-Iglesias, Manuel   +5 more
core   +1 more source

Multidrug-resistant Pseudomonas aeruginosa from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime–avibactam

Infection and Drug Resistance, 2018
Stan D Atkin,1 Shadaan Abid,1 Michael Foster,1 Moumita Bose,1 Ashley Keller,1 Rita Hollaway,2 Helio S Sader,3 David E Greenberg,1,4 James D Finklea,1 Mariana Castanheira,3 Raksha Jain1,4 1Department of Internal Medicine, University of Texas Southwestern ...
Atkin SD, Abid S, Foster M, Bose M, Keller A, Hollaway R, Sader HS, Greenberg DE, Finklea JD, Castanheira M, Jain R   +10 more
doaj  

Prevalence and mortality of ceftazidime/avibactam-resistant KPC-producing Klebsiella pneumoniae bloodstream infections (2018–2022) [PDF]

Funding Information: Open access funding provided by Università degli Studi di Torino within the CRUI-CARE Agreement. This research was supported by EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project ...
Bianco, Gabriele, Costa, Cristina, Bastos, Paulo, Almeida, André, Cavallo, Rossana, Boattini, Matteo, Comini, Sara, De Rosa, Francesco Giuseppe, Corcione, Silvia   +8 more
core   +1 more source

In vitro activity of ceftazidime-avibactam combination in in vitro checkerboard assays [PDF]

, 2015
Contains fulltext : 153132.pdf (Publisher’s version ) (Open Access)To evaluate the in vitro effects of the combination of ceftazidime and avibactam on the MICs of both compounds, checkerboard assays were performed for 81 clinical ...
Nichols, W.W., Melchers, M.J.B., Mouton, Johan, Melchers, MJ, van Mil, AC, Berkhout, J., Mil, A.C. van, Mouton †, J.W., Mouton, J.W., Berkhout, J, Nichols, WW   +10 more
core   +2 more sources

Activity of ceftazidime-avibactam combinations against carbapenem-resistant Klebsiella pneumoniae assessed by checkerboard method

: The aim of this study is to detect the carbapenemase type and to determine the in vitro effects of ceftazidime/avibactam-colistin, ceftazidime/avibactam-meropenem and ceftazidime/avibactam-tigecycline combinations against Carbapenem-Resistant ...
Ayten Nur Uzun, Uzun, Ayten Nur, Hilal Tanriverdi, Tanriverdi, Hilal, GENÇ, SERPİL, Serpil Genç   +5 more
core   +1 more source

Carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection successfully treated with ceftazidime/avibactam plus tigecycline

, 2020
Ceftazidime/avibactam combines ceftazidime with a new beta-lactam that successfully that inhibits Amber Class A and D carbapenemases.We report a clinical case of a 61 year-old man with a carbapenemase-producing Klebsiella pneumoniae intra-abdominal ...
Mariana Guedes, Nuno Rocha-Pereira, Raquel Duro, Isabel Abreu, Telma Fonseca   +4 more
core   +1 more source