Results 81 to 90 of about 13,154 (163)

Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li, Fei Zeng, Jie Zhang, Yuangong Zhang, Wenjuan Yin   +4 more
wiley   +1 more source

Advances in antibiotic therapy in the critically ill [PDF]

, 2016
Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains ...
Antonelli, Massimo, Bassetti, Matteo, Calandra, Thierry, Chastre, Jean, De Backer, Daniel, François, Bruno, Karam, George, Rello, Jordi, Roberts, Jason A., Taccone, Fabio S., Torres, Antoni, Universitat Autonoma de Barcelona, Vincent, Jean-Louis, Welte, Tobias   +13 more
core   +2 more sources

In vitro Synergistic Activity of Ceftazidime-Avibactam in Combination with Aztreonam or Meropenem Against Clinical Enterobacterales Producing blaKPC or blaNDM

Infection and Drug Resistance, 2023
Junyang Kuai,1 Yawei Zhang,1 Binghuai Lu,2 Hongbin Chen,1 Yulin Zhang,2 Henan Li,1 Yuanyuan Wang,3 Qi Wang,1 Hui Wang,1 Xiaojuan Wang1 1Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of China ...
Kuai J, Zhang Y, Lu B, Chen H, Zhang Y, Li H, Wang Y, Wang Q, Wang H, Wang X   +9 more
doaj  

Successful treatment of KPC-MDR septic shock with ceftazidime-avibactam in a pediatric critically ill patient

IDCases, 2019
Ceftazidime–avibactam is a combination agent consisting of the β-lactamase inhibitor avibactam and the broad-spectrum cephalosporin ceftazidime. There are no published case reports or studies evaluating the use of CAZ-AVI in pediatric critically ill ...
Maria Vargas, Antonio Riccardo Buonomo, Pasquale Buonanno, Carmine Iacovazzo, Giuseppe Servillo   +4 more
doaj   +1 more source

Persistent Burkholderia cepacia Bacteremia in Reconstructive Surgery: Resistance to Ceftazidime/Avibactam and Co‐Trimoxazole With Risk of Infective Endocarditis—A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Persistent Burkholderia cepacia bacteremia in soft tissue infections creates diagnostic and therapeutic challenges due to its resistance profile and potential for endovascular involvement. Early culture‐guided therapy, multidisciplinary coordination, and vigilance for complications, such as infective endocarditis, are essential for achieving ...
Chukwuka Elendu, Dependable C. Amaechi, Tochi C. Elendu, Emmanuel C. Amaechi, Ijeoma D. Elendu, Adaobi S. Ikedilo   +5 more
wiley   +1 more source

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli [PDF]

, 2017
Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing β ...
Baker, K R, Guardabassi, L, Jana, B, Sigurðardóttir, H H   +3 more
core   +2 more sources

Bloodstream Infection Caused by Carbapenemase‐Producing Enterobacterales in a Tertiary Hospital of Colombia: A 6 Year Retrospective Study

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background The global spread of carbapenemase‐producing Enterobacterales (CPE) has emerged as a significant public health challenge. However, epidemiological studies on CPE infections in Latin America remain scarce. This study aims to characterize bloodstream infections (BSIs) caused by CPE at a tertiary hospital over a 6‐year period and analyze the ...
Juan David Cáceres-González, Jorge Álvarez, Lorena Matta-Cortés, Ernesto Martínez-Buitrago, Johann A. Ospina-Galindez, Claudia C. Paredes-Amaya, Bishnu P. Marasini   +6 more
wiley   +1 more source

Effective antibiotic conservation by emergency antimicrobial stewardship during a drug shortage [PDF]

, 2016
We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam
Casabar, Ed, Durkin, Michael J, Hays, Amanda J, Hsueh, Kevin, Jafarzadeh, S. Reza, Krekel, Tamara, Lane, Michael A, Reyes, Maria, Ritchie, David J   +8 more
core   +2 more sources

Bloodstream infection caused by KPC-producing Klebsiella pneumoniae resistant to ceftazidime/avibactam: epidemiology and genomic characterization [PDF]

, 2020
Objectives: The aim of this study was to evaluate the incidence of ceftazidime/avibactam resistance among Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) strains isolated from patients with bloodstream infection.
Ambretti S., Campoli C., Gaibani P., Re M.C., Viale P.L.   +4 more
core   +1 more source

A Study on Ceftazidime/Avibactam and Aztreonam Synergy Among Aztreonam-resistant Metallo-β-lactamase Producing Enterobacterales in a Tertiary Care Hospital

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Global detection of bacteria harboring metallo-β-lactamase (MBL) genes has increased at an alarming rate. However, there is no concurrent increase in available antibiotics for treatment, which has turned these infections into a public ...
Adelyn D’SOUZA, Rachana SHETTY, Asha Pai KB   +2 more
doaj   +1 more source