, 2017 Since 2010 the new antimicrobials introduced have activity against resistant Gram negative bacteria, long half-lives against Gram positive bacteria, better activity against Clostridium difficile, and safer antifungal properties. Limiting factors to using
Roland, Will
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Enfermedades infecciosas y microbiologia clinica (English ed.), 2017 Antimicrobial resistance in Enterobacteriaceae is increasing worldwide and is making treating infections caused by multidrug-resistant Enterobacteriaceae a challenge. The use of β-lactam agents is compromised by microorganisms harboring extended-spectrum β-lactamases (ESBLs) and other mechanisms of resistance.
López-Hernández, Inmaculada +9 more
openaire +4 more sources
Characterization of Ceftazidime-Avibactam-Resistant Carbapenem-Resistant Enterobacteriaceae, United States, 2015–2017 [PDF]
Infection Control & Hospital Epidemiology, 2020 Background: Carbapenem-resistant Enterobacteriaceae (CRE) are a major public health problem. Ceftazidime-avibactam (CZA) is a treatment option for CRE approved in 2015; however, it does not have activity against isolates with metallo-β-lactamases (MBLs). Emerging resistance to CZA is a cause for concern.
Uzma Ansari +15 more
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Mediterranean Journal of Infection Microbes and Antimicrobials, 2023 Introduction: Increasing ceftazidime-avibactam (CZA) resistance in P. aeruginosa isolates is of serious concern worldwide. Therefore, studies on the underlying resistance mechanisms gain even more importance. The aim of this study was to investigate the presence of beta-lactamase genes reported to be associated with resistance, including metallo-beta ...
Neslihan ARICI, Elif Seren TANRIVERDİ
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Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC- producing Enterobacteriaceae [PDF]
, 2018 Introduction: Difficult Gram-negative infections are increasingly treated with new β-lactamase inhibitor combinations, e.g. ceftazidime/avibactam.
Doumith, Michel +5 more
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Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients
Journal of Clinical Laboratory Analysis, EarlyView.In this study conducted at an oncology hospital, BCID2 panel results for the rapid identification of microorganisms and resistance genes in positive blood culture samples were compared with conventional culture methods. The BCID2 panel provided faster results and showed a high correlation with traditional methods.
İpek Mumcuoğlu +6 more
wiley +1 more source
Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients. [PDF]
, 2016 This study aimed to investigate the pharmacokinetics (PK), safety, and tolerability of a single dose of ceftazidime-avibactam in pediatric patients. A phase I, multicenter, open-label PK study was conducted in pediatric patients hospitalized with an ...
Armstrong, Jon +15 more
core
Empiric antibiotic therapy in urinary tract infection in patients with risk factors for antibiotic resistance in a German emergency department [PDF]
, 2018 Background: The aim of this study was to identify clinical risk factors for antimicrobial resistances and multidrug resistance (MDR) in urinary tract infections (UTI) in an emergency department in order to improve empirical therapy. Methods: UTI cases
Bischoff, Sebastian +4 more
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Activity of Ceftazidime-Avibactam against Fluoroquinolone-Resistant Enterobacteriaceae and Pseudomonas aeruginosa [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT Ceftazidime-avibactam and comparator antibiotics were tested by the broth microdilution method against 200 Enterobacteriaceae and 25 Pseudomonas aeruginosa strains resistant to fluoroquinolones (including strains with the extended-spectrum β-lactamase [ESBL] phenotype and ...
C, Pitart +4 more
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KPC-Mediated Resistance to Ceftazidime-Avibactam and Collateral Effects in Klebsiella pneumoniae
Antimicrobial Agents and Chemotherapy, 2021 Carbapenem-resistant Enterobacterales , such as Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae , represent a major threat to public health due to their rapid spread.
Jacqueline Findlay +3 more
openaire +3 more sources