Results 81 to 90 of about 13,550 (188)

Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC- producing Enterobacteriaceae [PDF]

, 2018
Introduction: Difficult Gram-negative infections are increasingly treated with new β-lactamase inhibitor combinations, e.g. ceftazidime/avibactam.
Livermore, David M., Doumith, Michel, Nichols, Wright W., Jamrozy, Dorota, Woodford, Neil, Mushtaq, Shazad   +5 more
core   +1 more source

Genomic characterization of ceftazidime/avibactam-resistant Klebsiella pneumoniae: a retrospective analysis on clinical isolates from an Italian transplant unit

Frontiers in Microbiology
IntroductionKlebsiella pneumoniae infections are a significant healthcare concern due to advancing antimicrobial resistance rates and virulence genes’ detection. Specifically, ceftazidime/avibactam resistance is increasingly diffused among K.
Emanuele Nicitra, Emanuele Nicitra, Maddalena Calvo, Ilenia Martina Pia Filannino, Nicolò Musso, Grete Francesca Privitera, Davide Lo Porto, Andrea Cona, Francesco Monaco, Alessandra Mularoni, Stefania Stefani, Stefania Stefani, Dafne Bongiorno   +12 more
doaj   +1 more source

Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant β-Lactam Resistance Mechanisms [PDF]

, 2016
The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections.
Martínez-Martínez, Luis, Navarro Risueño, Ferran, Pascual Leone, Álvaro, Conejo, M Carmen, Cabot, Gabriel, Conejo, M. Carmen, Navarro, Ferrán, Ocampo-Sosa, Alain Antonio, Ocampo-Sosa, Alain A, Torrens, Gabriel, Pascual, Álvaro, Zamorano, Laura, Oliver, Antonio, Ocampo-Sosa, Alain A.   +13 more
core   +1 more source

A Study on Ceftazidime/Avibactam and Aztreonam Synergy Among Aztreonam-resistant Metallo-β-lactamase Producing Enterobacterales in a Tertiary Care Hospital

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Global detection of bacteria harboring metallo-β-lactamase (MBL) genes has increased at an alarming rate. However, there is no concurrent increase in available antibiotics for treatment, which has turned these infections into a public ...
Adelyn D’SOUZA, Rachana SHETTY, Asha Pai KB   +2 more
doaj   +1 more source

isolates resistant to ceftazidime/avibactam and cefiderocol in a university hospital in Madrid, Spain

, 2023
20.500.12530/87908Ceftazidime/avibactam and cefiderocol are two of the latest antibiotics with activity against a wide variety of Gram-negatives, including carbapenem-resistant Enterobacterales.
Soriano, Cruz, Pérez-Viso, Blanca, Ruiz-Garbajosa, Patricia, Raúl De Pablo, Cruz Soriano, Patricia Ruiz-Garbajosa, Juan Antonio Castillo-Polo, Rafael Cantón, Castillo-Polo, Juan Antonio, Cantón, Rafael, María Isabel Morosini, Hernández-García, Marta, Morosini, María Isabel, De Pablo, Raúl, Blanca Pérez-Viso, Marta Hernández-García   +15 more
core   +1 more source

Activity of ceftazidime/avibactam against problem Enterobacteriaceae and Pseudomonas aeruginosa in the UK, 2015-2016 [PDF]

, 2017
Background: Ceftazidime/avibactam combines an established oxyimino-cephalosporin with the first diazabicyclooctane β-lactamase inhibitor to enter clinical use.
Michel Doumith, Neil Woodford, Katie L Hopkins, David M Livermore, Livermore, David M, Doumith, Michel, Hill, Robert, Hopkins, Katie L, Meunier, Danièle, Pike, Rachel, Staves, Peter, Danièle Meunier, Rachel Pike, Woodford, Neil, Peter Staves, Robert Hill   +15 more
core   +1 more source

A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

Background The emergence of β-lactamase-producing bacteria limits the effectiveness of β-lactam (BL) antibiotics, and the combination with a β-lactamase inhibitor (BLI) aims to counteract this resistance.
O'Jeanson, Amaury, O'Jeanson, Amaury,, Nielsen, Elisabet I.,, Friberg, Lena E., Nielsen, Elisabet I., Friberg, Lena E.,   +5 more
core   +1 more source

Evaluation of ceftazidime/avibactam in combination with colistin against KPC-2-producing Klebsiella pneumoniae in static and dynamic time-kill experiments

Objectives Ceftazidime/avibactam is used for severe infections caused by carbapenemase-producing Klebsiella pneumoniae. Combination therapy with older antibiotics is frequently used, but the supporting data are limited.
Sandegren, Linus, Allander, Lisa, O'Jeanson, Amaury, Vikdahl, Emma, Lagerbäck, Pernilla, Tängdén, Thomas, Chatzopoulou, Margarita   +6 more
core   +1 more source

In vitro Synergistic Activity of Ceftazidime-Avibactam in Combination with Aztreonam or Meropenem Against Clinical Enterobacterales Producing blaKPC or blaNDM

Infection and Drug Resistance, 2023
Junyang Kuai,1 Yawei Zhang,1 Binghuai Lu,2 Hongbin Chen,1 Yulin Zhang,2 Henan Li,1 Yuanyuan Wang,3 Qi Wang,1 Hui Wang,1 Xiaojuan Wang1 1Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of China ...
Kuai J, Zhang Y, Lu B, Chen H, Zhang Y, Li H, Wang Y, Wang Q, Wang H, Wang X   +9 more
doaj  

Evolution of ceftazidime-avibactam and cefiderocol resistance in ST131-H30R1-Escherichia coli isolates with KPC-3 mutants and application of FTIR biotyping

Microbiology Spectrum
Ceftazidime-avibactam and cefiderocol represent two of the few alternatives for infections by KPC-producing Enterobacterales. We reported the emergence of resistance to both ceftazidime-avibactam and cefiderocol in a KPC-producing ST131-Escherichia coli (
Juan Antonio Castillo-Polo, Marta Hernández-García, Ainhize Maruri-Aransolo, Carmen de la Vega, Patricia Ruiz-Garbajosa, Rafael Cantón   +5 more
doaj   +1 more source