Results 101 to 110 of about 11,407 (210)

Suboptimal ceftazidime-avibactam exposure drives sequential blaKPC mutations and intra-host coexistence of Klebsiella pneumoniae harboring distinct variants leading to persistent infection

Microbiology Spectrum
KPC-producing Klebsiella pneumoniae infections are a rising global health threat. The factors driving blaKPC mutations during treatment and their contribution to infection persistence remain unclear.
Feng Yang, Weiwei Yang, Jinghao Zhang, Chengkang Tang, Li Ding, Siquan Shen, Yanhao Zhou, Hongyu Zhao, Jiaojiao Zhou, Fupin Hu   +9 more
doaj   +1 more source

Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li, Fei Zeng, Jie Zhang, Yuangong Zhang, Wenjuan Yin   +4 more
wiley   +1 more source

Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles [PDF]

, 2017
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against ‘problem’ isolates sent to the UK national reference laboratory from July 2015, when ...
Aiysha Chaudhry, Akova, Al-Agamy, Babouee Flury, Berrazeg, Bonacorsi, Bonfiglio, Bonfiglio, Cabot, Cabot, Castón, Cavallo, Chang, Chen, Daniele Meunier, David M. Livermore, Doumith, Edelstein, Farrell, Gelfand, Hernández-Tejedor, Katie L. Hopkins, Livermore, Livermore, Livermore, Livermore, Livermore, Neil Woodford, Normark, Papp-Wallace, Papp-Wallace, Peter Staves, Poirel, Poirel, Rachael Adkin, Rachel Pike, Reynolds, Robert Hill, Shazad Mushtaq, Sousa-Dominguez, Strateva, Sucher, Vickery, Williams   +43 more
core   +1 more source

Persistent Burkholderia cepacia Bacteremia in Reconstructive Surgery: Resistance to Ceftazidime/Avibactam and Co‐Trimoxazole With Risk of Infective Endocarditis—A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Persistent Burkholderia cepacia bacteremia in soft tissue infections creates diagnostic and therapeutic challenges due to its resistance profile and potential for endovascular involvement. Early culture‐guided therapy, multidisciplinary coordination, and vigilance for complications, such as infective endocarditis, are essential for achieving ...
Chukwuka Elendu, Dependable C. Amaechi, Tochi C. Elendu, Emmanuel C. Amaechi, Ijeoma D. Elendu, Adaobi S. Ikedilo   +5 more
wiley   +1 more source

Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem [PDF]

, 2016
BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes).
Benvenuti, Manuela, Docquier, Jean-Denis, Luca, Filomena De, Mangani, Stefano, Nordmann, Patrice, Poirel, Laurent, Pozzi, Cecilia, Rossolini, Gian Maria   +7 more
core   +1 more source

A Study on Ceftazidime/Avibactam and Aztreonam Synergy Among Aztreonam-resistant Metallo-β-lactamase Producing Enterobacterales in a Tertiary Care Hospital

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Global detection of bacteria harboring metallo-β-lactamase (MBL) genes has increased at an alarming rate. However, there is no concurrent increase in available antibiotics for treatment, which has turned these infections into a public ...
Adelyn D’SOUZA, Rachana SHETTY, Asha Pai KB   +2 more
doaj   +1 more source

Bloodstream Infection Caused by Carbapenemase‐Producing Enterobacterales in a Tertiary Hospital of Colombia: A 6 Year Retrospective Study

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background The global spread of carbapenemase‐producing Enterobacterales (CPE) has emerged as a significant public health challenge. However, epidemiological studies on CPE infections in Latin America remain scarce. This study aims to characterize bloodstream infections (BSIs) caused by CPE at a tertiary hospital over a 6‐year period and analyze the ...
Juan David Cáceres-González, Jorge Álvarez, Lorena Matta-Cortés, Ernesto Martínez-Buitrago, Johann A. Ospina-Galindez, Claudia C. Paredes-Amaya, Bishnu P. Marasini   +6 more
wiley   +1 more source

Advances in antibiotic therapy in the critically ill [PDF]

, 2016
Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains ...
Antonelli, Massimo, Bassetti, Matteo, Calandra, Thierry, Chastre, Jean, De Backer, Daniel, François, Bruno, Karam, George, Rello, Jordi, Roberts, Jason A., Taccone, Fabio S., Torres, Antoni, Universitat Autonoma de Barcelona, Vincent, Jean-Louis, Welte, Tobias   +13 more
core   +2 more sources

Genomic characterization of ceftazidime/avibactam-resistant Klebsiella pneumoniae: a retrospective analysis on clinical isolates from an Italian transplant unit

Frontiers in Microbiology
IntroductionKlebsiella pneumoniae infections are a significant healthcare concern due to advancing antimicrobial resistance rates and virulence genes’ detection. Specifically, ceftazidime/avibactam resistance is increasingly diffused among K.
Emanuele Nicitra, Emanuele Nicitra, Maddalena Calvo, Ilenia Martina Pia Filannino, Nicolò Musso, Grete Francesca Privitera, Davide Lo Porto, Andrea Cona, Francesco Monaco, Alessandra Mularoni, Stefania Stefani, Stefania Stefani, Dafne Bongiorno   +12 more
doaj   +1 more source

Clinical Epidemiological Analysis of the Genotypic Spectrum and Mortality Risk in Carbapenem‐Resistant Klebsiella pneumoniae (CRKP) Infections

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Carbapenem‐resistant Klebsiella pneumoniae (CRKP) has become a global public health threat, with significantly increased morbidity and mortality among high‐risk inpatients. High‐risk genotypes of CRKP, primarily including K. pneumoniae carbapenemase (KPC), oxacillinase‐48–like (OXA‐48–like), New Delhi metallo‐β‐lactamase (NDM), imipenemase ...
Qiongfang Zhang, Ze Fang, Bo Fang, Hailing Zeng, Jiaojiao Xu, Muhammad Abu Bakr Shabbir   +5 more
wiley   +1 more source