Results 101 to 110 of about 13,550 (188)

In vitro activity of ceftazidime-avibactam and aztreonam-avibactam against multidrug-resistant Klebsiella pneumoniae and Escherichia coli

, 2019
Background: Increasing resistance to broad-spectrum cephalosporin and carbapenem in Enterobacteriaceae makes it challenging to select appropriate antibiotics. There are limited treatment options for these pathogens.
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Prevalence and mortality of ceftazidime/avibactam-resistant KPC-producing Klebsiella pneumoniae bloodstream infections (2018–2022) [PDF]

Funding Information: Open access funding provided by Università degli Studi di Torino within the CRUI-CARE Agreement. This research was supported by EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project ...
Bianco, Gabriele, Costa, Cristina, Bastos, Paulo, Almeida, André, Cavallo, Rossana, Boattini, Matteo, Comini, Sara, De Rosa, Francesco Giuseppe, Corcione, Silvia   +8 more
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Ceftazidime–Avibactam Pharmacokinetic Comparative In Vivo/In Vitro Study in a Critically Ill Children Under High‐Volume Continuous Venovenous Hemodiafiltration

Pharmacology Research & Perspectives
Ceftazidime–avibactam is a novel cephalosporin/beta‐lactamase inhibitor combination developed to address increasing antimicrobial resistance. This report presents a comparative study of the pharmacokinetics of ceftazidime and avibactam, utilizing in ...
Michael Thy, Alexandre Debs, Gabrielle Lui, Leo Froelicher‐Bournaud, Jean‐Marc Tréluyer, Mehdi Oualha   +5 more
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Synergistic Effect of Ceftazidime-Avibactam with Aztreonam on Carbapenemase-Positive Klebsiella pneumoniae MBL+, NDM+

Mateusz Szymański,1,2 Małgorzata M Skiba,2 Małgorzata Piasecka,2 Alina Olender3 1Human Anatomy Department, Medical University, Lublin, Poland; 2Intensive Care Unit, Stefan Cardinal Wyszyński District Specialist Hospital ...
Szymański M, Olender A, Skiba MM, Piasecka M   +3 more
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KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study

, 2018
KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonization is a major risk factor for developing systemic infections. Ceftazidime/avibactam could have a role as decolonization therapy in special situations PATIENTS AND METHODS: retrospective ...
Pallotto, Carlo, Sodano, Giuseppe, Righi, Elda, Righi E., Graziano, Elena, Carannante N., Di Caprio G., Bernardo M., Sodano G., Bernardo, Mariano, Tascini C., Sartor, Assunta, Carannante, Novella, Tascini, Carlo, Bassetti, Matteo, Mallardo, Enza, Mallardo E., Sartor A., Di Caprio, Giovanni, Bassetti M., Graziano E., Francisci D., Pallotto C., Francisci, Daniela   +23 more
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In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates

, 2019
WOS: 000471951900029PubMed ID: 30576787Objectives: Infections caused by multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) are a growing problem because of the limited options for treatment.
Mataracı Kara, Emel, Özbek Çelik, Berna, Yılmaz, Mesut   +2 more
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Reduced catalytic activity of KPC β-lactamase can increase ceftazidime resistance

Communications Biology
β-Lactamases confer bacterial resistance by hydrolyzing β-lactam antibiotics. Klebsiella pneumoniae carbapenemases (KPCs) are a major cause of resistance to carbapenems, but combinations of β-lactams with β-lactamase inhibitors, such as ceftazidime ...
André Birgy, Dignite Fabrice Ngango, Murugesan Palaniappan, Shahlo O. Solieva, Devin G. Kelly, Zhizeng Sun, Gregory Bowman, Timothy Palzkill   +7 more
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Global epidemiology and resistance-related mutations of ceftazidime-avibactam-resistant Klebsiella pneumoniae strains

Frontiers in Cellular and Infection Microbiology
ObjectiveCarbapenem-resistant Klebsiella pneumoniae (CRKP) infection has become a global public health problem in recent years. However, ceftazidime-avibactam-resistant (CAZ/AVI-R) Klebsiella pneumoniae (K. pneumoniae) has emerged during treatment for CRKP infection.
Xie, Xinya, Chen, Jiali, Qi, Lihua, Yuan, Yue, Long, Jiamin, Wu, Xuelian, Liu, Yuan, Guo, Jinpeng, Wang, Changjun, Meng, Xiangzhao, Liu, Xiong, Chen, Yong, Liu, Jie   +12 more
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Impaired Inhibition by Avibactam and Resistance to the Ceftazidime-Avibactam Combination Due to the D ¹⁷⁹ Y Substitution in the KPC-2 β-Lactamase

, 2017
The ceftazidime-avibactam antibiotic combination was recently shown to be at risk for the emergence of resistance under treatment. To gain insight into the underlying mechanism, we have analyzed the catalytic properties of a Klebsiella ...
Michel Arthur, Fabrice Compain
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The bacterial etiology and antimicrobial susceptibility of lower respiratory tract infections in Vietnam

Annals of Clinical Microbiology and Antimicrobials
Background Lower respiratory tract infection (LRTI) remains the leading infectious cause of morbidity and mortality globally. Key bacterial pathogens include Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli ...
Tran Thi Ngoc Dung, Chau Vinh, Pham Hong Anh, Vo Kim Phuong Linh, Ha Thanh Tuyen, Pham Thanh Tam, Nguyen Phu Huong Lan, Truong Thien Phu, Nguyen Su Minh Tuyet, Pham Hong Nhung, Van Dinh Trang, Nguyen Thi Van, Quynh Nguyen, Nguyen Thi Thanh, Thomas Kesteman, H. Rogier van Doorn, Guy Thwaites, Pham Thanh Duy   +17 more
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