Results 121 to 130 of about 105,631 (265)

Structural Basis of Reduced Susceptibility to Ceftazidime-Avibactam and Cefiderocol in Enterobacter cloacae Due to AmpC R2 Loop Deletion

Antimicrobial Agents and Chemotherapy, 2020
Ceftazidime-avibactam and cefiderocol are two of the latest generation β-lactam agents that possess expanded activity against highly drug-resistant bacteria, including carbapenem-resistant Enterobacterales. Here, we show that structural changes in AmpC β-
A. Kawai, C. McElheny, Alina Iovleva, Ellen G. Kline, N. Sluis-Cremer, R. Shields, Y. Doi   +6 more
semanticscholar   +1 more source

The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]

, 2017
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K, Diaz, Jose J, Jr, Huston, Jared M, May, Addison K, Mazuski, John E, Mollen, Kevin P, Nadler, Evan P, O\u27Neill, Patrick J, Prince, Jose M, Rosengart, Matthew R, Sawyer, Robert G, Tessier, Jeffrey M   +11 more
core   +3 more sources

Challenges in Diagnosing and Treating Percutaneous Nephrostomy‐Related Urinary Tract Infection in Cancer Patients: A Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective We aimed to evaluate medical decisions regarding urinary tract infection (UTI), describe associated microorganisms, and assess potential risk factors for percutaneous nephrostomy‐related UTI (UTI‐PN). Methods Oncological patients who underwent percutaneous nephrostomy (PN) were included. We assessed percutaneous nephrostomy procedure‐
Jeferson Rodrigo Zanon, Marcelo Jenné Mimica, José Humberto Tavares Guerreiro Fregnani, Ricardo dos Reis   +3 more
wiley   +1 more source

Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.

Journal of Antimicrobial Chemotherapy, 2020
BACKGROUND MBL-producing strains of Enterobacteriaceae are a major public health concern. We sought to define optimal combination regimens of ceftazidime/avibactam with aztreonam in a hollow-fibre infection model (HFIM) of MBL-producing strains of ...
T. Lodise, N. M. Smith, Nicholas O'Donnell, A. Eakin, Patricia N. Holden, Katie Rose Boissonneault, Jieqiang Zhou, Xun Tao, J. Bulitta, V. Fowler, H. Chambers, R. Bonomo, Brian T. Tsuji   +12 more
semanticscholar   +1 more source

In Vitro Activities of Nisin and Nisin Derivatives Alone and In Combination with Antibiotics against Staphylococcus Biofilms [PDF]

, 2016
peer-reviewedThe development and spread of pathogenic bacteria that are resistant to the existing catalog of antibiotics is a major public health threat.
Cotter, Paul D., Field, Des, Hill, Colin, O'Connor, Rory, Ross, R Paul   +4 more
core   +1 more source

Phenotypic and Genotypic Study of Antibiotic Resistance blaPER‐1, blaVEB, and blaSHV‐1 Genes in Clinical Isolates of Pseudomonas aeruginosa

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Pseudomonas aeruginosa is a non‐fermentative, opportunistic Gram‐negative bacterium that causes 10%–15% of nosocomial and burn wound infections worldwide. This bacterium is resistant to various antibiotics through multiple mechanisms, including acquisition of resistance genes.
Milad Gholampour Matin, Reza Shapouri, Mohammadreza Nahaei, Mojtaba Mohammadi Roknabadi, Rasoul Shokri   +4 more
wiley   +1 more source

A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia [PDF]

, 2017
Ceftazidime/avibactam comprises the broad-spectrum cephalosporin ceftazidime and the non-β-lactam β-lactamase inhibitor avibactam. This phase 3, randomised, double-blind study (NCT01726023) assessed the efficacy and safety of ceftazidime/avibactam plus ...
Chen, Q., Chow, J.W., Kim, M.J., Laud, P.J., Nguyen, D.A., Qin, X., Song, J., Stone, G.G., Tran, B.G., Wang, L.   +9 more
core   +1 more source

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

mBio, 2017
The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies.
Melissa D. Barnes, Marisa L. Winkler, Magdalena A. Taracila, Malcolm G. Page, Eric Desarbre, Barry N. Kreiswirth, Ryan K. Shields, Minh-Hong Nguyen, Cornelius Clancy, Brad Spellberg, Krisztina M. Papp-Wallace, Robert A. Bonomo   +11 more
doaj   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

Journal of Hospital Medicine, Volume 21, Issue 5, Page 477-486, May 2026.
Visual Abstract Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living.
Jumpei Taniguchi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga   +4 more
wiley   +1 more source

The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]

, 2018
Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M., Bethel, Christopher R., Bonomo, Robert A., Giannini, Estefanía, Klinke, Sebastian, Llarrull, Leticia Irene, Mojica, María F., Otero, Lisandro Horacio, Palacios, Antonela Rocio, Taracila, Magdalena A., Vila, Alejandro Jose   +10 more
core   +1 more source