Results 61 to 70 of about 63,048 (236)

Proposal of metagenomic-origin LRA-5 as a precursor of active β-lactamases through Tyr69Gln and Val166Glu amino acid substitutions: a functional and structural analysis

Antimicrobial Agents and Chemotherapy
Wild-type LRA-5, recovered from Alaskan soil samples, shares no more than 33% amino acid sequence identity with enzymes from pathogens like PER β-lactamases. Recombinant E.
Gabriela D'Amico González, María Margarita Rodríguez, Pedro Penzotti, Florencia Brunetti, Barbara Ghiglione, Luke A. Moe, Daniela Centrón, Gabriel Gutkind, Lin Gao, Shozeb Haider, Rachel A. Powers, Sebastián Klinke, Pablo Power   +12 more
doaj   +1 more source

Molecular docking result of ceftazidime.

, 2014
(A) Binding pose of ceftazidime in the binding site of blaOXA-1 (B) A close-up view of the binding pose of ceftazidime; Protein structure is shown in surface model and the ligand is shown in stick model. (C) H-bond network with protein residues are shown.
Anand Anbarasu (539441), Madhan Sugumar (539439), Sudha Ramaiah (539442), Anand Manoharan (255198), K. M. Kumar (539440)   +4 more
core   +1 more source

Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats [PDF]

, 2000
The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline)
Matzke, Gary R., Frye, Reginald F., Kellum, John A, Alkharfy, Khalid M.   +3 more
core   +1 more source

Ceftazidime and meropenem MIC for engineered mutants.

, 2023
Ceftazidime and meropenem MIC for engineered mutants.
Kay A. Ramsay (11856887), Attika Rehman (15503576), Iain L. Lamont (382593), Lois W. Martin (15503582), Samuel T. Wardell (15503579), Scott C. Bell (8538324), Wayne M. Patrick (7271693), Craig Winstanley (75404)   +7 more
core   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source

Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats [PDF]

, 2011
The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2).
Lacchini, Raúl, Barrena, Jorge Pablo, Villagra, Sergio, Reynaldi, Francisco J., Rule, Roberto   +4 more
core   +2 more sources

Dual delivery of active antibactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers

International Journal of Nanomedicine, 2016
Yung-Hen Hsu,1,2 Chang-Tun Lin,2 Yi-Hsun Yu,1,2 Ying-Chao Chou,1,2 Shih-Jung Liu,1,2 Err-Cheng Chan3 1Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 2Department of Mechanical Engineering, 3Department of Medical Biotechnology and ...
Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC   +5 more
doaj  

An Application of a Physiologically Based Pharmacokinetic Approach to Predict Ceftazidime Pharmacokinetics in a Pregnant Population

Pharmaceutics
Physiological changes during pregnancy can alter maternal and fetal drug exposure. The objective of this work was to predict maternal and umbilical ceftazidime pharmacokinetics during pregnancy.
Khaled Abduljalil, Iain Gardner, Masoud Jamei   +2 more
doaj   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian, Nipit Tangchitnob   +1 more
wiley   +1 more source

Ceftazidime Is the Key Diversification and Selection Driver of VIM-Type Carbapenemases

mBio, 2018
In recent decades, carbapenems have been considered the last line of antibiotic therapy for Gram-negative bacterial infections. Unfortunately, strains carrying a high diversity of β-lactamases able to hydrolyze carbapenems have emerged in the clinical ...
Laura Martínez-García, José M. González-Alba, Fernando Baquero, Rafael Cantón, Juan Carlos Galán   +4 more
doaj   +1 more source