Results 131 to 140 of about 8,708 (251)

A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia [PDF]

, 2017
Ceftazidime/avibactam comprises the broad-spectrum cephalosporin ceftazidime and the non-β-lactam β-lactamase inhibitor avibactam. This phase 3, randomised, double-blind study (NCT01726023) assessed the efficacy and safety of ceftazidime/avibactam plus ...
Chen, Q., Chow, J.W., Kim, M.J., Laud, P.J., Nguyen, D.A., Qin, X., Song, J., Stone, G.G., Tran, B.G., Wang, L.   +9 more
core   +1 more source

Ceftolozane/Tazobactam for the Treatment of Complicated Infections in Hospital Settings—A French Real-world Study

Open Forum Infectious Diseases
Background This study describes the conditions of use of ceftolozane/tazobactam (C/T) and associated outcomes in French hospital settings. Methods This was a prospective, multicenter, French observational study. Patients who received at least 1 dose of C/
J. Timsit, J. Mootien, B. Akrich, X. Bourge, I. Brassac, B. Castan, Carole Mackosso, Linsay Monteiro Tavares, Fabrice Ruiz, D. Boutoille, R. Ruimy   +10 more
semanticscholar   +1 more source

Critical evaluation of ceftolozane–tazobactam for complicated urinary tract and intra-abdominal infections

Therapeutics and Clinical Risk Management, 2016
Stephanie E Giancola,1 Monica V Mahoney,2 Tiffany E Bias,3,4 Elizabeth B Hirsch2,51Department of Pharmacy, St Mary’s Medical Center, Huntington, WV, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Hahnemann University Hospital, 4Drexel ...
Giancola SE, Mahoney MV, Bias TE, Hirsch EB   +3 more
doaj  

The impact of initial antibiotic treatment failure: Real-world insights in patients with complicated, health care-associated intra-abdominal infection [PDF]

, 2019
Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation of antibiotic therapy) for health
Baelen, Elisa, Karve, Sudeep, Peeters, Pascale, Potter, Danielle, Rodríguez-Baño, Jesús, Rojas-Farreras, Sonia, Ryan, Kellie   +6 more
core   +1 more source

Antimicrobial Resistance (AMR) and Multidrug Resistance (MDR): Overview of Current Approaches, Consortia and Intellectual Property Issues [PDF]

, 2017
The supply of new diagnostics and treatments is insufficient to keep up with the increase in antimicrobial resistance (AMR) and multidrug resistance (MDR) as older medicines are used more widely and microbes develop resistance to them.
Bhagwandin, Niresh, Jenner, Andrew, Kowalski, Stanley P.   +2 more
core   +1 more source

Ceftolozane/tazobactam: Literature review of its activity on Taiwanese isolates before its launch in Taiwan (2012–2021)

Heliyon
Ceftolozane, a novel cephalosporin, combined with tazobactam, a known β-lactamase inhibitor, shows robust antipseudomonal activity, although it doesn't cover carbapenemases.
Chien-Ming Chao, Wen-Liang Yu
semanticscholar   +1 more source

Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
Extracellular bacterial metabolites have potential as markers of bacterial growth and resistance emergence but have not been evaluated in dynamic in vitro studies.
Jessica R. Tait, Dovile Anderson, R. Nation, Darren J. Creek, C. Landersdorfer   +4 more
semanticscholar   +1 more source

Cost-effectiveness analysis of CTZ/TAZ for the treatment of ventilated hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in Japan

BMC Health Services Research
Background Resistant bacterial infections, particularly those caused by gram-negative pathogens, are associated with high mortality and economic burdens.
Risako Takaya, Nobuyoshi Mori, Eiko Saito, Sachiko Ohde   +3 more
doaj   +1 more source

Effect of Ceftaroline, Ceftazidime/Avibactam, Ceftolozane/Tazobactam, and Meropenem/Vaborbactam on Establishment of Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice

Pathogens and Immunity
Background: The potential for promotion of intestinal colonization with healthcare-associated pathogens by new antibiotics used to treat infections due to multidrug-resistant Gram-negative bacilli is unclear.
B. Hausman, Samir Memic, Jennifer Cadnum, Elizabeth Zink, Brigid Wilson, C. Donskey   +5 more
semanticscholar   +1 more source

Susceptibility of Gram-negative pathogens collected in Israel to ceftolozane/tazobactam, imipenem/relebactam and comparators: SMART 2018–22

JAC-Antimicrobial Resistance
Objectives To assess the in vitro antimicrobial activity of ceftolozane/tazobactam, imipenem/relebactam and comparator agents against clinical isolates of Gram-negative bacilli collected in Israel from 2018 to 2022. Methods Six clinical laboratories each
M. Wise, C. DeRyke, I. Alekseeva, F. Siddiqui, K. Young, M. Motyl, Daniel F. Sahm   +6 more
semanticscholar   +1 more source