Results 41 to 50 of about 95,684 (265)

Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of Neisseria gonorrhoeae genomes

Microbiology Spectrum, 2023
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health issue. Machine learning (ML) is a powerful tool that can aid in identifying mutations and predicting their impact on AMR.
Sung Min Ha, Eric Y. Lin, Jeffrey D. Klausner, Paul C. Adamson   +3 more
doaj   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, EarlyView.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source

Bacitracin enhances ceftriaxone susceptibility of the high-level ceftriaxone-resistant gonococcal FC428 clone

Microbiology Spectrum, 2023
Neisseria gonorrhoeae is a multidrug-resistant bacterial pathogen for which ceftriaxone mono-antimicrobial therapy and ceftriaxone plus azithromycin dual-antimicrobial therapy are the only remaining effective therapies.
Yuhua Gu, Shuaijie Song, Qingrui Zhu, Ruilin Jiao, Xu'ai Lin, Fan Yang, Stijn van der Veen   +6 more
doaj   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Synergistic Antimicrobial Activity of Ceftriaxone and Polyalthia longifolia Methanol (MEPL) Leaf Extract against Methicillin-Resistant Staphylococcus aureus and Modulation of mecA Gene Presence

Antibiotics, 2023
Medicinal plants are an essential source of traditional curatives for numerous skin diseases. Polyalthia longifolia (Sonn.) Thwaites (Annonaceae family) is a medicinal plant used to cure skin illnesses. P.
Valiappan Ranjutha, Yeng Chen, Lamya Ahmed Al-Keridis, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen, Subash C. B. Gopinath, Sreenivasan Sasidharan   +8 more
doaj   +1 more source

Life Claiming Anaphylaxis to Intravenous Ceftriaxone after Negative Skin Test [PDF]

, 2005
Antibiotic prophylaxis before surgical procedures is commonly practiced. Hypersensitivity reactions to antibacterial drugs are most feared complications; which have varying grades of presentation.
Dr. Raktima A, Dr. Gaurav K, Dr. Girdhar K, Dr. Prashant K   +3 more
core  

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

CEFTRIAXONE-INDUCED PERIORBITAL EDEMA [PDF]

, 2019
Cephalosporins are widely prescribed antibiotics for common infections and also used for prophylactic measures. Ceftriaxone is a third-generation cephalosporin which is known to cause hypersensitivity reactions presenting in various manifestations ...
Bs, Sujatha, ANUHYA, VINAYAKA, Nayak, Veena, Somu, Keerthi, Thomson, Sereene Rose   +4 more
core   +1 more source

Ceftriaxone‐associated immune haemolytic anaemia: A patient‐level systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Ceftriaxone can cause acute haemolysis. Its clinical presentation, risk factors, and outcomes remain incompletely characterized. We conducted a systematic review of published cases with patient‐level data, following international guidelines and with registration in PROSPERO (CRD420261338709). Reports were identified through three bibliographic
Sonja Miotti, Giada Wyttenbach, Mario G. Bianchetti, Camilla Lavagno, Pietro Camozzi, Gregorio P. Milani, Renato Gualtieri, Sebastiano A. G. Lava, Pietro B. Faré, Simone Janett   +9 more
wiley   +1 more source

Multicenter Population Pharmacokinetic Study of Unbound Ceftriaxone in Critically Ill Patients

, 2022
The objective of this study was to describe the total and unbound population pharmacokinetics of ceftriaxone in critically ill adult patients and to define optimized dosing regimens.
Joynt, Gavin M., Sime, Fekade B., Roberts, Jason A, Joynt, Gavin M, Wong, Gloria, Heffernan, Aaron J, Sime, Fekade B, Ungerer, Jacobus, Heffernan, Aaron J., Lipman, Jeffrey, Kumta, Nilesh, Wallis, Steven C, Wallis, Steven C., McWhinney, Brett, Roberts, Jason A.   +14 more
core   +1 more source