Results 91 to 100 of about 66,137 (309)

Herbal therapy for treating rheumatoid arthritis (review) [PDF]

, 2011
Background Herbal medicine interventions have been identified as having potential benefit in the treatment of rheumatoid arthritis (RA). Objectives To update an existing systematic (Cochrane) review of herbal therapies in RA. Search methods
Cameron, Melainie, Chrubasik, Sigrun, Gagnier, Joel J.   +2 more
core   +1 more source

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman, Ankita Narang, Ziad Al Bkhetan, Robyn L. Woods, Suzanne G. Orchard, Alice J. Owen, Michelle A. Fravel, Julia Gilmartin‐Thomas, Joanne Ryan, Peter D. Fransquet, Rory Wolfe, Chenglong Yu, John J. McNeil, Paul Lacaze, Michael E. Ernst   +14 more
wiley   +1 more source

Co-crystal of Tramadol Hydrochloride–Celecoxib (ctc): A Novel API–API Co-crystal for the Treatment of Pain

, 2017
We have identified a co-crystal of tramadol hydrochloride–celecoxib (ctc; E-58425/MR308), a novel active pharmaceutical ingredient (API)–API co-crystal formed by an intrinsic 1:1 molecular ratio of rac-tramadol·HCl and celecoxib, which displays ...
C. Almansa, Ramon MercÃ, Nicolas Tesson, J. Farran, J. S., Carlos R. Plata-Salamán   +5 more
semanticscholar   +1 more source

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

Oncoimmunology, 2016
Two major challenges facing cancer immunotherapy are the relatively low therapeutic efficacy and the potential side effects. New drug delivery system and efficient drug combination are required to overcome these challenges.
Yongkui Li, Min Fang, Jian Zhang, Jian Wang, Yu Song, Jie Shi, Wei Li, Gang Wu, Jinghua Ren, Zheng Wang, W. Zou, Lin Wang   +11 more
semanticscholar   +1 more source

Transition Metal‐Promoted Direct CS and CSe Bond Formation from Csp3H Bonds

European Journal of Organic Chemistry, EarlyView.
This review summarizes the significant advancements in transition metal‐catalyzed direct chalcogenylation of Csp3H bonds over the past decade (2014–2024). The discussion is organized by transition metal catalysts, with particular emphasis on mechanistic insights of these transformations.
Douglas B. Paixão, Diego Seckler, Carla M. B. Gomes, Gul Badshah, Gabriel P. Bueno, Paulo H. Schneider, Ricardo S. Schwab, Daniel S. Rampon   +7 more
wiley   +1 more source

Acoustic-like dynamics of amorphous drugs in the THz regime [PDF]

arXiv, 2013
The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation.
arxiv  

Estimating the Cost and Carbon Output of Musculoskeletal Primary Care Management Decisions: A Retrospective Analysis of Electronic Health Records

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Healthcare accounts for up to 5% of worldwide carbon emissions and costs global economies an estimated $9 trillion annually. Primary care accounts for up to one‐fifth of all NHS carbon emissions, with musculoskeletal (MSK) pain accounting for 14%–30% of all primary care consultations.
Alex Braybrooke, Melissa Pegg, Rebecca Naylor, James Bailey, James Scott, Roanna Burgess, Dahai Yu, Simon Wathall, Kelvin P. Jordan, Robert Malcolm, Hayden Holmes, George Peat, Anirban Banerjee, Jonathan C. Hill   +13 more
wiley   +1 more source

Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis

BMC Cancer, 2018
Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental ...
L. Sharaf, Mridul Sharma, D. Chandel, G. Shukla   +3 more
semanticscholar   +1 more source

Royal Jelly, A Super Food, Protects Against Celecoxib-Induced Renal Toxicity in Adult Male Albino Rats

Canadian Journal of Kidney Health and Disease
Background: Celecoxib is a COX-2 nonsteroidal anti-inflammatory drug (NSAID). It is widely used for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Hesham A. M. I. Khalifa, Naglaa Z. H. Eleiwa, Heba A. Nazim   +2 more
doaj   +1 more source

Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance

Pharmaceutical Sciences, 2017
Background: Celecoxib is a non-steroidal anti-inflammatory drug used extensively in the treatment of pain, arthritis, and cancers. However, its administration is limited due to its several disadvantages including gastric irritation and hepatic first pass
Sepideh Mardani 1, Maryam Maghsoodi 2 * , Saeed Ghanbarzadeh 3,4, Ali Nokhodchi 5, Shadi Yaqoubi 6, Hamed Hamishehkar 7 *
doaj   +1 more source