Results 81 to 90 of about 25,624 (186)

Optimizing the Anti‐Inflammatory Efficacy of Pakistani Spice Blends: A Farm‐to‐Fork Analysis of Phytochemical Synergy and Processing Stability

eFood, Volume 7, Issue 4, August 2026.
This review aims to evaluate the anti‐inflammatory potential of these spice blends, emphasizing their synergistic mechanisms, and to investigate how cultivation practices, post‐harvest processing, and environmental stressors shape their medicinal efficacy. By addressing this gap, it seeks to provide a comprehensive framework for integrating traditional
Qudrat Ullah, Waqas Haider, Farhang Hameed Awlqadr, Ahmed Bilal, Muhammad Tayyab Arshad, Emmanuel Laryea   +5 more
wiley   +1 more source

The dual role of CCND1 in heterotopic ossification: A Non-canonical Pathway for Celecoxib treatment

Heliyon
Objective: To explore the effective targets of Celecoxib in the treatment of heterotopic ossification using network pharmacology methods. Methods: Potential molecules related to heterotopic ossification were obtained by retrieving the GEO and CTD ...
Wei Liu, Junchao Huang, Jianhai Hu, Ziheng Bu, Zheng Zhou, Jianing Yu, Huajun Wang, Xinbo Wu, Peng Wu   +8 more
doaj   +1 more source

Microgel‐Based Immunomodulatory Biomaterials for Regulating Macrophage Polarization

Journal of Biomedical Materials Research Part A, Volume 114, Issue 8, August 2026.
Macrophages are key regulators of the immune system. Modulating their phenotype from pro‐inflammatory (M1) to pro‐regenerative (M2) is key to engineering implantable tissue scaffolds for regenerative medicine. Understanding the cell‐matrix mechanosensitive trends macrophages exhibit with microgel‐based biomaterials will enhance future research.
Cody Tuftee, Muhammad Rizwan
wiley   +1 more source

The Cost-effectiveness of Celecoxib versus Non-steroidal Anti-inflammatory Drugs plus Proton-pump Inhibitors for Treating Osteoarthritis in Algeria

Journal of Health Economics and Outcomes Research, 2013
# Background Cyclooxygenase-2 inhibitors such as celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA), have fewer gastrointestinal side effects, but are more expensive ...
Nadir Hammoumraoui, Sid Ahmed Kherraf, Joaquin Mould-Quevedo, Tarek A. Ismail   +3 more
doaj  

Neuromuscular exercise in addition to celecoxib versus celecoxib alone for symptomatic and radiographic knee osteoarthritis: a randomized controlled trial

BMC Sports Science, Medicine and Rehabilitation
Background Neuromuscular exercise (NEXA) and celecoxib each are effective for treating knee osteoarthritis (OA), but the potential benefits of combination therapy remain unclear. The aim of this study was to investigate the effects of NEXA in addition to
Xiaotian Yang, Haixin Song, Xuqing Li, Tao Wu, Jianhua Li, Chengqi He   +5 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo

Drug Design, Development and Therapy, 2018
Jiayang He,1 Ping Fang,2 Xiang Zheng,2 Chenchen Wang,2 Tenghui Liu,2 Bowen Zhang,2 Jian Wen,2 Ren-ai Xu3 1Department of Pharmacy, The First Hospital of Jiaxing, Jiaxing, Zhejiang, China; 2Department of Pharmacology, School of Pharmacy of Wenzhou Medical
He JY, Fang P, Zheng X, Wang CC, Liu TH, Zhang BW, Wen J, Xu RA   +7 more
doaj  

Association Between Postoperative NSAID Use and Bleeding Following Transoral Robotic Surgery

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 2, Page 402-408, August 2026.
Abstract Objective To evaluate the safety and outcomes of NSAID use following transoral robotic surgery (TORS). Study Design Retrospective cohort study using propensity score matching. Setting Multi‐institutional database (TriNetX). Methods Patients undergoing TORS were identified using ICD‐10 codes.
Brayden Seliger, Jacob Beiriger, Milana Berry, Nilam Patel, Richard B. Cannon, Marcus M. Monroe, Hilary C. McCrary   +6 more
wiley   +1 more source

Efficient One‐Pot Synthesis of Dibenzoxanthenes Using a Vinylimidazolium‐Based Brønsted Acidic Ionic Liquid [VSBIM][Cl]: In Silico Evaluation of Drug‐Likeness, ADMET Properties, PASS Analysis, Antiviral Activity Prediction, and Molecular Docking Studies

ChemistryOpen, Volume 15, Issue 8, August 2026.
An efficient and solvent‐free sustainable one‐pot protocol is developed for the synthesis of broad range of dibenzoxanthenes using 5 mol% Bronsted acidic ionic liquid [VSBIM][Cl]. The versatility of the methodology was demonstrated by the effective synthesis of 19 dibenzoxanthene derivatives up to 90%–95% yields.
Talamarlla Deepthi, Barnali Maiti
wiley   +1 more source

Preoperative celecoxib use does not increase risk of myocardial infarction and may be protective against thromboembolic complications following total joint arthroplasty

Journal of Orthopaedic Reports
Purpose: The purpose of this study was to determine if preoperative celecoxib treatment raises the risk of postoperative 1) myocardial infarctions, 2) thromboembolic complications, 3) acute kidney injuries, 4) transfusions, and 5) readmissions. Materials
Matthew L. Magruder, Shabnam Parsa, Ariel N. Rodriguez, Mitchell Ng, Che Hang Jason Wong   +4 more
doaj   +1 more source