Results 91 to 100 of about 25,624 (186)

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, Volume 22, Issue 45, 13 August 2026.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Using Pharmacovigilance Data for Signal Detection of Drug Interactions for Rosuvastatin

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT The 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase inhibitor rosuvastatin is a substrate of breast cancer resistance protein (BCRP). BCRP inhibition increases rosuvastatin plasma concentrations and may result in concentration‐dependent muscle toxicity, at worst rhabdomyolysis.
Ronja Levomäki, Päivi Hirvensalo, Aleksi Tornio, Anne M. Filppula   +3 more
wiley   +1 more source

Multi‐Omics Integration Identifies PTGS2 as a Candidate Diagnostic Biomarker and Precise Therapeutic Target Related to Schisandra chinensis for Osteoarthritis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This study used multi‐layer methods such as network pharmacology, differential expression analysis, functional enrichment and GSEA, molecular docking, single‐cell transcriptomics and virtual knockout to analyze the molecular mechanism of Schisandra chinensis (SC) in treating osteoarthritis (OA).
Lingtian Min, Yikai You, Shiqi Ren, Cheng Chen   +3 more
wiley   +1 more source

Addressing ‘hard‐to‐fund’ research questions in bowel research: Exploring the role of decision architecture randomised trials

Colorectal Disease, Volume 28, Issue 8, August 2026.
Abstract Patients and health professionals face difficult decisions every day when choosing between standard‐of‐care treatments for the same disease. In bowel disease, some treatments are used interchangeably, but a lack of evidence may exist as to whether one is more effective than another. Randomised controlled trials provide robust evidence in these
Stephen J. Chapman, Carly Bisset, Hayley Fowler, Alice Murray, Jessica Banks, Judit Kovacs, Jim Tiernan, Julie Cornish, Susan Moug, Dale Vimalachandran, James H. Flory, Andrew Vickers, Clare Relton   +12 more
wiley   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1301-1311, August 2026.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long‐term effects on the risk of periodontitis remain unclear. Methods We emulated target trials using US electronic health records (1995–2019) to compare the 5‐year risk of incident ...
Ignacio Leiva‐Escobar, Aiswarya Puzhakkara Chennas, Zoheir Alayash, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Sebastian‐Edgar Baumeister, Michael Nolde   +7 more
wiley   +1 more source

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Drug Design, Development and Therapy, 2015
Sunyoung Lee,1,* Yonghyun Lee,1,2,* Wooseong Kim,1 Joon Nam,1 Seongkeun Jeong,1 Jin-Wook Yoo,1 Min-Soo Kim,1 Hyung Ryong Moon,1 Yunjin Jung11College of Pharmacy, Pusan National University, Busan, 2Bio-Nanomedicine Lab, Department of Biological Sciences ...
Lee S, Lee Y, Kim W, Nam J, Jeong S, Yoo JW, Kim MS, Moon HR, Jung Y   +8 more
doaj  

Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial. [PDF]

Basic Clin Pharmacol Toxicol
Saarikoski T, Saari TI, Backman JT, Niemi M, Neuvonen PJ, Olkkola KT, Laine K.   +6 more
europepmc   +1 more source

Celecoxib adjunct to antidepressants for major depressive disorder: Systematic review and meta-analysis. [PDF]

Brain Behav Immun Health
Srisurapanont M, Suradom C, Suttajit S.
europepmc   +1 more source

Comparison of transdermal and oral anti-inflammatory drugs on immediate post-operative pain control in total knee arthroplasty: a randomized controlled trial. [PDF]

Arthroplasty
Jaruthien N, Piriyamanun R, Ngarmukos S, Tanavalee A, Kampitak V, Tanavalee C, Amarase C.   +6 more
europepmc   +1 more source

Exploring celecoxib polymorph landscape using AIMNet2 machine learning interatomic potential. [PDF]

Chem Sci
Zheng P, Abramov YA, Sun CC, Isayev O.
europepmc   +1 more source