Results 91 to 100 of about 33,756 (203)

Computer-Aided Drug Repurposing: A Cyclooxygenase-2 Inhibitor Celecoxib as a Ligand for Estrogen Receptor Alpha

Indonesian Journal of Chemistry, 2015
A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines.
Enade Perdana Istyastono, Florentinus Dika Octa Riswanto, Sri Hartati Yuliani   +2 more
doaj   +1 more source

Intra‐articular Orthobiologics Show Statistically but Not Clinically Meaningful Improvements Compared With Viscosupplementation in Knee Osteoarthritis: A Network Meta‐analysis of Randomized Controlled Trials

Arthroscopy, Volume 42, Issue 10, Page 2291-2308, October 2026.
Purpose To evaluate the comparative effectiveness of intra‐articular platelet‐rich plasma (PRP), stromal vascular fraction (SVF), bone marrow aspirate concentrate (BMAC), umbilical cord‐derived mesenchymal stem cell (UC‐MSC), and hyaluronic acid (HA) for pain relief and functional improvement in patients with knee osteoarthritis through network meta ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Sung‐Hwan Kim   +5 more
wiley   +1 more source

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley   +1 more source

Optimasi Pembentukan Multikomponen Kristal Celecoxib-Piperin [PDF]

, 2020
Celecoxib merupakan obat golongan NSAID yang bekerja secara spesifik menghambat enzim siklooksigenase-2. Senyawa ini termasuk ke dalam BCS kelas II karena memiliki kelarutan yang rendah dan permeabilitas yang tinggi.
Fauziyyah, Dirfedli
core   +1 more source

Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats

Frontiers in Pharmacology
IntroductionIntestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a ...
Szilvia B. László, Barbara Hutka, Barbara Hutka, András S. Tóth, András S. Tóth, Tamás Hegyes, Zsuzsanna O. Demeter, Zsuzsanna O. Demeter, Arezoo Haghighi, Arezoo Haghighi, Gerda Wachtl, Gerda Wachtl, Ágnes Kelemen, Anna Jakab, Klára Gyires, Klára Gyires, Zoltán S. Zádori, Zoltán S. Zádori   +17 more
doaj   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source

A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia

, 2017
William L Pridgen,1 Carol Duffy,2 Judy F Gendreau,3 R Michael Gendreau3 1Innovative Med Concepts, LLC, 2Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, 3Gendreau Consulting, LLC, Poway, CA, USA Objective: Infections and other ...
Gendreau RM, Gendreau JF, Carol Duffy, Duffy, Carol, William L Pridgen, Duffy C, Judy F Gendreau, Gendreau, Judy F., Pridgen, William L., Pridgen WL, R Michael Gendreau, Gendreau, R. Michael   +11 more
core   +1 more source

Safety of Nonsteroidal Anti‐Inflammatory Drug Use in Traumatic Brain Injury

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Use of nonsteroidal anti‐inflammatory drugs (NSAIDs) after a traumatic brain injury (TBI) is controversial due to potential worsening of an intracranial hemorrhage (ICH). This study evaluated if NSAID use within 14 days of TBI was associated with a clinically significant progression of intracranial bleed (PIB).
Jennifer Beavers, Mary Katherine Cella Shultz, Leanne Atchison, Cara Lwin, Dandan Liu, Silky Chotai, Andrew J. Medvecz, Robel Beyene, Michael C. Smith, Bradley M. Dennis, Susan Hamblin   +10 more
wiley   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Revealing Changes in Celecoxib Nanostructured Lipid Carrier’s Bioavailability Using Hyaluronic Acid as an Enhancer by HPLC-MS/MS [PDF]

Yi Zhu,1,2,* Meiling Chen,3,* Chuangzan Yang,1,2 Geng Lu,1,2 Sa Huang,1,2 Meili Chen,3 Yufei Wang,4 Junfeng Ban1– 3 1Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2The Innovation Team for Integrating Pharmacy with ...
Huang S, Lu G, Zhu Y, Chen M, Ban J, Wang Y, Yang C   +6 more
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