Results 51 to 60 of about 66,137 (309)

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]

, 2007
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P, ANZINI M., BIAVA M, BOTTA M, CAPPELLI A, FORLI S, GHELARDINI C, MAKOVEC F, MANETTI, F, PATRIGNANI P, PERGOLA, CARLO, POCE G, PORRETTA GC, ROSSI, ANTONIETTA, ROVINI M, SAUTEBIN, LIDIA, SUPINO S, VIVOLI E   +17 more
core   +1 more source

Celecoxib treatment alleviates cerebral injury in a rat model of post-traumatic epilepsy [PDF]

PeerJ, 2023
Background An important factor contributing to the development and occurrence of post-traumatic epilepsy (PTE) is neuroinflammation and oxidative stress.
Lei Chen, Qingsheng Niu, Caibin Gao, Fang Du   +3 more
doaj   +2 more sources

Effect of cyclooxygenase-2 inhibitors in double J stent removal [PDF]

, 2022
Background: Celecoxib is a selective cyclooxygenase-2(COX-2) inhibitor that can reduce the inflammatory process during double J (DJ) stent removal procedure.
Abriansyah, Aryo Teguh, Rulianov, Rulianov, Santoso, Jumadi, Siregar, Safendra   +3 more
core   +2 more sources

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G₁ cell cycle arrest and autophagy

Molecular Cancer, 2009
Background Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear.
Gao Qiuhan, Yong Sook, Zhu Congju, Kang Khong, Wong Meng   +4 more
doaj   +1 more source

Non-steroidal anti-inflammatory drugs—changes in prescribing may be warranted [PDF]

, 2006
No abstract ...
Madhok, R., McKellar, G., Singh, G., Wu, O.   +3 more
core   +1 more source

Devitrification of amorphous celecoxib [PDF]

AAPS PharmSciTech, 2005
The purpose of this research was to analyze the devitrification of amorphous celecoxib (CEL) in the presence of different stressors (temperature, pressure, and/or humidity) encountered during processing of solid dosage forms. Amorphous CEL was prepared in situ in the analytical instruments, as well as in laboratory, by quench-cooling of melt process ...
Arvind K. Bansal, Piyush Gupta
openaire   +3 more sources

Celecoxib Enhances Radiosensitivity via Induction of G2-M Phase Arrest and Apoptosis in Nasopharyngeal Carcinoma

Cellular Physiology and Biochemistry, 2014
Background: Previous work has proposed that celecoxib may be able to enhance the effects of radiotherapy. However, the underlying mechanism of this activity has not yet been determined.
Shui-xing Zhang, Qian-hui Qiu, Wen-bo Chen, Chang-hong Liang, Biao Huang   +4 more
doaj   +1 more source

Jitteriness/anxiety syndrome caused by coadministration of celecoxib, a selective COX‐2 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis

Neuropsychopharmacology Reports, 2023
Antidepressant‐induced jitteriness/anxiety syndrome is characterized as anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, and (hypo)mania, which appear immediately after initiation or increased ...
Toshinori Shirata, Shinji Yano, Keisuke Noto, Muneaki Kanno, Akihito Suzuki   +4 more
doaj   +1 more source

Challenges and Opportunities for Celecoxib Repurposing

Pharmaceutical Research, 2023
AbstractDrug repositioning, also known as drug repurposing, reprofiling, or rediscovery, is considered to be one of the most promising strategies to accelerate the development of new original drug products. Multiple examples of successful rediscovery or therapeutic switching of old molecules that did not show clinical benefits or safety in initial ...
Urszula Bąk, Anna Krupa
openaire   +3 more sources

New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship. [PDF]

PLoS ONE, 2017
Sixteen new carboxamide derivatives bearing substituted benzenesulphonamide moiety (7a-p) were synthesized by boric acid mediated amidation of appropriate benzenesulphonamide with 2-amino-4-picoline and tested for anti-inflammatory activity. One compound
David Izuchukwu Ugwu, Uchechukwu Chris Okoro, Hilal Ahmad   +2 more
doaj   +1 more source