Results 31 to 40 of about 25,572 (179)

Jitteriness/anxiety syndrome caused by coadministration of celecoxib, a selective COX‐2 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis

Neuropsychopharmacology Reports, 2023
Antidepressant‐induced jitteriness/anxiety syndrome is characterized as anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, and (hypo)mania, which appear immediately after initiation or increased ...
Toshinori Shirata, Shinji Yano, Keisuke Noto, Muneaki Kanno, Akihito Suzuki   +4 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Celecoxib Enhances Radiosensitivity via Induction of G2-M Phase Arrest and Apoptosis in Nasopharyngeal Carcinoma

Cellular Physiology and Biochemistry, 2014
Background: Previous work has proposed that celecoxib may be able to enhance the effects of radiotherapy. However, the underlying mechanism of this activity has not yet been determined.
Shui-xing Zhang, Qian-hui Qiu, Wen-bo Chen, Chang-hong Liang, Biao Huang   +4 more
doaj   +1 more source

Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells

International Journal of Nanomedicine, 2011
Tae-Ho Kim1*, Young-Il Jeong2*, Shu-Guang Jin2, Jian Pei2, Tae-Young Jung1, Kyung-Sub Moon1, In-Young Kim1, Sam-Suk Kang1, Shin Jung1,21Department of Neurosurgery, 2Brain Tumor Research Laboratory, Chonnam National University Research Institute of ...
Jung S., Kang SS, Kim IY, Jung TY, Pei J, Jin SG, Jeong YI, Kim TH   +7 more
doaj  

Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting

Cell Communication and Signaling
Celecoxib, a selective COX-2 inhibitor, has demonstrated anti-liver cancer effects in various preclinical models and clinical traits. However, prolonged use of celecoxib can lead to drug resistance, necessitating higher doses to maintain efficacy, which ...
Chujiao Hu, Zhirui Zeng, Xin Bao, Dahuan Li, Huading Tai, Haohao Zeng, Cheng Luo, Lei Tang, Tengxiang Chen, Shi Zuo   +9 more
doaj   +1 more source

Intra‐articular Orthobiologics Show Statistically but Not Clinically Meaningful Improvements Compared With Viscosupplementation in Knee Osteoarthritis: A Network Meta‐analysis of Randomized Controlled Trials

Arthroscopy, EarlyView.
Purpose To evaluate the comparative effectiveness of intra‐articular platelet‐rich plasma (PRP), stromal vascular fraction (SVF), bone marrow aspirate concentrate (BMAC), umbilical cord‐derived mesenchymal stem cell (UC‐MSC), and hyaluronic acid (HA) for pain relief and functional improvement in patients with knee osteoarthritis through network meta ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Sung‐Hwan Kim   +5 more
wiley   +1 more source

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G₁ cell cycle arrest and autophagy

Molecular Cancer, 2009
Background Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear.
Gao Qiuhan, Yong Sook, Zhu Congju, Kang Khong, Wong Meng   +4 more
doaj   +1 more source

Arthroscopic Segmental Labral Reconstruction Using a Presutured Iliotibial Band Allograft Soaked in Bone Marrow Aspirate Concentrate

Arthroscopy Techniques, EarlyView.
Abstract Labral reconstruction is a surgical procedure in which a graft is used to replace irreparable acetabular labral tissue. Biologic augmentation with bone marrow aspirate concentrate harvested from the ipsilateral iliac crest is increasingly used to enhance graft incorporation and potentially improve functional outcomes, especially in patients ...
Jacob D. Kodra, Arthur Saroyan, Kevin Lord, Andrew Schab, Jeremy K. Ansah‐Twum, Jon Salandra, Renato Locks, Andrew E. Jimenez   +7 more
wiley   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

IMPROVEMENT THE RELEASE AND AVAIALBILITY OF CELECOXIB CO-ADSORBATE FROM FLOATING CAPSULES [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2012
Celecoxib is a selective COX-2 inhibitor non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis ...
Sherif Abu-elyazid
doaj   +1 more source