Results 31 to 40 of about 33,756 (203)

Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) : a systematic structured review of the literature [PDF]

, 2007
Adverse events triggered by non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1.
Weberschock, Tobias Bernd Bernd, Boehncke, Wolf-Henning, Tobias Bernd Weberschock, Sylke-Monina Müller, Sandra Boehncke, Müller, Sylke-Monina, Wolf-Henning Boehncke, Weberschock, Tobias Bernd, Boehncke, Sandra   +8 more
core   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Clinical Efficacy of Celecoxib with and without Caffeine versus Ibuprofen for Pain Control following Crown Lengthening Surgery

Journal of Dental School, 2019
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed pain control medications following periodontal surgery. This study aimed to compare the efficacy of three drug regimens namely celecoxib, celecoxib + caffeine and
Niloofar Jenabian, Ali Akbar Moghadamnia, Reza Beyraghshamshir   +2 more
doaj   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources

Protective effect of lycopene on celecoxib induced hepatotoxicity in albino rats: A histological study

Pakistan Journal of Pharmaceutical Sciences, 2020
Celecoxib, a selective COX-2 inhibitor, is one of the most effective and widely used analgesic and anti-inflammatory drugs. However it has been reported that celecoxib may cause adverse effects on liver, kidney and GIT.
Maria Khan, Somia Gul, Aisha Abdul Haq, Kiran Rafiq, Quratulain Leghari, Farrukh Mustafa Memon Karachi, Pakistan   +6 more
doaj   +1 more source

Celecoxib Induces Heme Oxygenase-1 Expression in Macrophages and Vascular Smooth Muscle Cells Via Ros-Dependent Signaling Pathway

, 2012
The multiple cytoprotective mechanisms of heme oxygenase HO- 1 make it a promising therapeutic target. This study investigated whether the selective cyclooxygenase COX-2 inhibitor, celecoxib, can upregulate HO-1 expression.
王彰勳;何豐名;康皓程;林琬琬;黃國晉, WANG, JANG-SHIUN;HO, FENG-MING;KANG, HAO-CHENG;LIN, WAN-WAN;HUANG, KUO-CHIN   +1 more
core   +1 more source

Formulation, Characterization, and in Vivo Evaluation of Celecoxib-PVP Solid Dispersion Nanoparticles Using Supercritical Antisolvent Process

Molecules, 2014
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process.
Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek, Min-Soo Kim   +3 more
doaj   +1 more source

Efficacy and safety of celecoxib on the incidence of recurrent colorectal adenomas: a systematic review and meta-analysis [PDF]

, 2019
Background: Celecoxib has previously been shown to be effective in reducing recurrent colorectal adenomas, but its long-term effects are unknown. In addition, safety issues are of major concern. Therefore, we examined the efficacy and safety of celecoxib
Nathisuwan, Surakit, Veettil, Sajesh Kalkandi, Ching, Siew Mooi, Lim, Kean Ghee, Jinatongthai, Peerawat, Chaiyakunapruk, Nathorn, Kew, Siang Tong   +6 more
core   +1 more source

Evaluation of Celecoxib-Lactose Incompatibility Reactions at Solid State using Physicochemical Methods [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2021
Background & Aims:  Drug excipient incompatibility evaluation is an important part of pre-formulation studies. Drug-excipient interaction may affect drug stability, bioavailability, therapeutic effects, efficacy, and safety.
Ali Fattahzadeh, Azin Jahangiri, Naser Ranjkeshzadeh, Faranak Ghaderi   +3 more
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source