Results 11 to 20 of about 25,572 (179)

Etanercept/celecoxib on improving MRI inflammation of active ankylosing spondylitis: A multicenter, open-label, randomized clinical trial

Frontiers in Immunology, 2022
ObjectiveTo investigate the efficacy and safety of clinical, magnetic resonance imaging (MRI) changes in active ankylosing spondylitis (AS) patients with etanercept and celecoxib alone/combined treatment.MethodsA randomized controlled trial was conducted
Liudan Tu, Minjing Zhao, Xiaohong Wang, Qingcong Kong, Zena Chen, Qiujing Wei, Qiuxia Li, Qinghong Yu, Zhizhong Ye, Shuangyan Cao, Zhimin Lin, Zetao Liao, Qing Lv, Jun Qi, Ou Jin, Yunfeng Pan, Jieruo Gu   +16 more
doaj   +1 more source

Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells. [PDF]

PLoS ONE, 2013
Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can elicit anti-tumor effects in various malignancies. Here, we sought to clarify the role of autophagy in celecoxib-induced cytotoxicity in human urothelial carcinoma (UC) cells.
Kuo-How Huang, Kuan-Lin Kuo, I-Lin Ho, Hong-Chiang Chang, Yuan-Ting Chuang, Wei-Chou Lin, Ping-Yi Lee, Shih-Chen Chang, Chih-Kang Chiang, Yeong-Shiau Pu, Chien-Tso Chou, Chen-Hsun Hsu, Shing-Hwa Liu   +12 more
doaj   +1 more source

Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. [PDF]

PLoS ONE, 2012
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that has been reported to elicit anti-proliferative response in various tumors. In this study, we aim to investigate the antitumor effect of celecoxib on urothelial carcinoma (UC) cells and the ...
Kuo-How Huang, Kuan-Lin Kuo, Shyh-Chyan Chen, Te-I Weng, Yuan-Ting Chuang, Yu-Chieh Tsai, Yeong-Shiau Pu, Chih-Kang Chiang, Shing-Hwa Liu   +8 more
doaj   +1 more source

Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats.

PLoS ONE, 2014
Nonsteroidal anti-inflammatory drugs (NSAIDs) can produce adverse effects by inhibiting prostaglandin (PG) synthesis. A PGE1 analogue, misoprostol, is often utilized to alleviate NSAID-related gastrointestinal side effects. This study examined the effect
Dustin L Cooper, Derek E Murrell, Christopher M Conder, Victoria E Palau, Grace E Campbell, Shaun P Lynch, James W Denham, Angela V Hanley, Kenny W Bullins, Peter C Panus, Krishna Singh, Sam Harirforoosh   +11 more
doaj   +1 more source

The Efficacy and Safety of Celecoxib in Addition to Standard Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Current Oncology, 2022
The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy. Randomized controlled trials (RCTs) that evaluated the efficacy and safety
Shi-Yu Ye, Jia-Yi Li, Teng-Hui Li, Yong-Xi Song, Jing-Xu Sun, Xiao-Wan Chen, Jun-Hua Zhao, Yuan Li, Zhong-Hua Wu, Peng Gao, Xuan-Zhang Huang   +10 more
doaj   +1 more source

Celecoxib concentration predicts decrease in prostaglandin E₂ concentrations in nipple aspirate fluid from high risk women

BMC Cancer, 2008
Background Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating plasma and breast nipple aspirate ...
Flynn John T, Ruhlen Rachel L, Hewett John E, Qin Wenyi, Sauter Edward R, Rottinghaus George, Chen Yin-Chieh   +6 more
doaj   +1 more source

Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS

Biochemistry Research International, 2017
Objective. To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. Method. In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes.
Xiang Zheng, Jian Wen, Teng-hui Liu, Qiu-Geng Ou-yang, Jian-ping Cai, Hong-yu Zhou   +5 more
doaj   +1 more source

Metronomic Celecoxib Therapy in Clinically Available Dosage Ablates Hepatocellular Carcinoma via Suppressing Cell Invasion, Growth, and Stemness in Pre-Clinical Models

Frontiers in Oncology, 2020
ObjectiveTo investigate the anti-carcinogenic effect of metronomic Celecoxib (i.e., frequent administration in clinically available doses) against hepatocellular carcinoma (HCC) in the perspective of metastasis, spontaneous hepatocarcinogenesis, cancer ...
Chun-Chieh Yeh, Chun-Chieh Yeh, Pei-Ying Liao, Pei-Ying Liao, Sudhir Pandey, Su-Yung Yung, Hsueh-Chou Lai, Hsueh-Chou Lai, Long-Bin Jeng, Long-Bin Jeng, Wei-Chun Chang, Wei-Chun Chang, Wen-Lung Ma, Wen-Lung Ma, Wen-Lung Ma, Wen-Lung Ma   +15 more
doaj   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2

Journal of Experimental & Clinical Cancer Research, 2008
Background The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model. Methods For immunoblot analysis of COX-
Han Jae, Oh Young, Park Won, Pyo Hongryull   +3 more
doaj   +1 more source