Results 1 to 10 of about 25,572 (179)
Pharmaceutics, 2020 Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related ...
In-Soo Yoon +2 more
exaly +3 more sources
Celecoxib inhibits COX-2 and initiates YAP-dependent mitochondrial apoptosis via YBX1 shuttling in hepatocellular carcinoma [PDF]
Cell Communication and SignalingDrug resistance poses a significant challenge in hepatocellular carcinoma (HCC) treatment. In this study, we aimed to assess the efficacy of celecoxib against HCC and uncover the underlying mechanism.
Zhe Hou +9 more
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Celecoxib Inhibits Vasculogenic Mimicry and Induces Apoptosis in the D17 Canine Osteosarcoma Cell Line via the COX-2/PGE2 Signaling Axis [PDF]
Veterinary SciencesOsteosarcoma is a highly aggressive canine bone tumor characterized by early metastasis and resistance to chemotherapy. Vasculogenic mimicry (VM), the ability of tumor cells to form microvascular channels independent of endothelial cells, can contribute ...
Jungwoo Jo +5 more
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Effect of Cyclooxygenase-2 Inhibitors in Double J Stent Removal under Local Anesthesia
The Annals of African Surgery, 2021 Introduction: Celecoxib is a selective cyclooxygenase-2(COX-2) inhibitor that can reduce the inflammatory process during double J (DJ) stent removal procedure.
Rulianov Rulianov +3 more
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Celecoxib for osteoarthritis [PDF]
Cochrane Database of Systematic Reviews, 2017 Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms.
Livia, Puljak +5 more
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC50 =
Mostafa M. M. El-Miligy +5 more
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Inhibition mechanism of the intracellular transporter Ca2+-pump from sarco-endoplasmic reticulum by the antitumor agent dimethyl-celecoxib. [PDF]
PLoS ONE, 2014 Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear.
Ramón Coca +4 more
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Journal of Orthopaedic Surgery and Research, 2023 Background Tendon injuries are among the most common musculoskeletal disorders. Celecoxib possesses an effective anti-inflammatory activity in the tendon injury treatment. Lactoferrin has a great potential for the tendon regeneration.
Yaonan Zhang +6 more
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ANTI-INFLAMMATORY, ANALGESIC AND ULCEROGENIC POTENCY OF CURCUMIN IN COMPARISON WITH CELECOXIB AND PREDNISOLONE [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 The present study investigates the anti-inflammatory, analgesic effect, and gastric disturbance of curcumin compared with celecoxib and prednisolone.
Tarek Khamis +4 more
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INTERACTIONS OF CELECOXIB WITH DIFFERENT ANTIDIABETIC DRUGS IN DIABETIC RATS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2016 The selective cyclooxygenase-2 inhibitor, celecoxib, can be prescribed to type 2 diabetic patients receiving oral hypoglycemic agents. This study was conducted to assess whether celecoxib affect the hypoglycemic activity of oral hypoglycemic agents in ...
Manar Nader, Shehta Said, Manar Helal
doaj +1 more source