Results 61 to 70 of about 58,334 (260)

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types [PDF]

, 2015
The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells.
Bastos-Pereira, Benavides, Booth, Booth, Bruzziches, Carón, Chandrasekharan, Chen, Chen, Choi, Chuang, Cremesti, Cruickshanks, Das, Das, Eberle, Florio, Flower, Formelli, Francis, Gandelman, Giannini, González, Grösch, Hamed, Hayden, Holliday, Hsieh, Hsu, Huang, Johnson, Kardosh, Kern, Kim, Komalavilas, Kots, Liu, Mao, Nandakishore, Nichols, Oh, Park, Park, Pilane, Piplani, Pyrko, Rabkin, Ramer, Reinehr, Roberts, Russwurm, Saba, Sabichi, Schiffmann, Schiffmann, Shen, Shin, Soh, Song, Swiergiel, Tang, Tripathi, Tsutsumi, Veronesi, Vosooghi, Wang, Watanabe, Werner, Williams, Yacoub, Yu   +70 more
core   +2 more sources

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. [PDF]

PLoS ONE, 2014
We have previously shown that celecoxib in combination with an antibiotic, increase the bacterial sensitivity to antibiotics. However, the underlying molecular mechanism remained elusive.
Madhavi Annamanedi, Arunasree M Kalle
doaj   +1 more source

EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]

, 2019
Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe, Chen, David, Feng, Xi, Gupta, Nalin, Gupta, Sonali, Liu, Sharon, Rosi, Susanna   +6 more
core   +1 more source

Organ‐sparing strategies in patients with MSI/dMMR tumors including Lynch syndrome: Current state of the art and future perspectives for clinical decision‐making

International Journal of Cancer, EarlyView.
Abstract Deficiency in DNA mismatch repair (dMMR) is a common pathway of carcinogenesis across different tumor types and confers a characteristic microsatellite instability‐high (MSI‐H) molecular phenotype. The MSI‐H/dMMR phenotype may arise from an inherited pathogenic variant in the context of Lynch syndrome and is most frequently observed in ...
Martin Duval, Antoine Dardenne, Thomas Samaille, Leo Mas, Jérémie H. Lefèvre, Xavier Dray, Mathilde Wagner, Romain Cohen, Thierry André   +8 more
wiley   +1 more source

Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

Journal of Pharmacological Sciences, 2017
Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone healing. We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID, inhibited the canonical Wnt/β-catenin signaling pathway. Since this pathway also
Akihiro Nagano, Masaki Arioka, Fumi Takahashi-Yanaga, Etsuko Matsuzaki, Toshiyuki Sasaguri   +4 more
doaj   +1 more source

Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression

Journal of Nanobiotechnology, 2023
Intervertebral disc degeneration (IDD) has been identified as one of the predominant factors leading to persistent low back pain and disability in middle-aged and elderly people.
Yunhao Wang, Genjiang Zheng, Xiaoxing Xie, Wei Yu, Jianxi Wang, Fazhi Zang, Chen Yang, Qiangqiang Xiao, Rongcheng Zhang, Leixin Wei, Xiaodong Wu, Lei Liang, Peng Cao, Chen Xu, Jing Li, Bo Hu, Tao Zhang, Jinglei Wu, Huajiang Chen   +18 more
doaj   +1 more source

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source