Results 61 to 70 of about 50,777 (219)

Effect of periocular injection of celecoxib and propranolol on ocular level of vascular endothelial growth factor in a diabetic mouse model [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the effects of periocular injection of propranolol and celecoxib on ocular levels of vascular endothelial growth factor (VEGF) in a diabetic mouse model. METHODS: Forty 4-6wk BALB-C male mice weighing 20-25 g were used.
Saman Nassiri, Gholamreza Houshmand, Mostafa Feghhi, Alireza Kheirollah, Mohammad Bahadoram, Nariman Nassiri   +5 more
doaj   +1 more source

In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]

, 2010
The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg, Goltsov, Alexey, Goltsov, Gregory, Goryanin, Igor, Humphery-Smith, Ian, Lebedeva, Galina   +5 more
core   +5 more sources

Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells

International Journal of Nanomedicine, 2011
Tae-Ho Kim1*, Young-Il Jeong2*, Shu-Guang Jin2, Jian Pei2, Tae-Young Jung1, Kyung-Sub Moon1, In-Young Kim1, Sam-Suk Kang1, Shin Jung1,21Department of Neurosurgery, 2Brain Tumor Research Laboratory, Chonnam National University Research Institute of ...
Jung S., Kang SS, Kim IY, Jung TY, Pei J, Jin SG, Jeong YI, Kim TH   +7 more
doaj  

Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]

, 2014
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R, Kakadia, Pratibha G.
core   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]

, 2019
Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe, Chen, David, Feng, Xi, Gupta, Nalin, Gupta, Sonali, Liu, Sharon, Rosi, Susanna   +6 more
core   +1 more source

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types [PDF]

, 2015
The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells.
Bastos-Pereira, Benavides, Booth, Booth, Bruzziches, Carón, Chandrasekharan, Chen, Chen, Choi, Chuang, Cremesti, Cruickshanks, Das, Das, Eberle, Florio, Flower, Formelli, Francis, Gandelman, Giannini, González, Grösch, Hamed, Hayden, Holliday, Hsieh, Hsu, Huang, Johnson, Kardosh, Kern, Kim, Komalavilas, Kots, Liu, Mao, Nandakishore, Nichols, Oh, Park, Park, Pilane, Piplani, Pyrko, Rabkin, Ramer, Reinehr, Roberts, Russwurm, Saba, Sabichi, Schiffmann, Schiffmann, Shen, Shin, Soh, Song, Swiergiel, Tang, Tripathi, Tsutsumi, Veronesi, Vosooghi, Wang, Watanabe, Werner, Williams, Yacoub, Yu   +70 more
core   +2 more sources

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, EarlyView.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer [PDF]

, 2008
Background While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor growth and prolong survival ...
Wenyi Qin, Weizhu Zhu, John E Hewett, George Rottinghaus, Yin-Chieh Chen, John T Flynn, Beth Kliethermes, Ferdinando Mannello, Edward R Sauter, JD Vassalli, V Ellis, MJ Duffy, PA Andreasen, Z Ma, JR Merchan, PO Chappuis, JR Merchan, F Blasi, K Bajou, K Bajou, P Ballabh, YH Chuang, S Lanza-Jacoby, GD Basu, ER Sauter, HN Andrews, ER Sauter, ER Sauter, ER Sauter, F Schonberger, W Qin, VA Ploplis, MJ Duffy   +32 more
core   +2 more sources