Results 81 to 90 of about 66,137 (309)

Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model [PDF]

, 2011
Celecoxib, a selective cyclooxygenase-2 inhibitor, has shown potential anticancerous activity against majority of solid tumors especially on patients with colon cancer.
Banerjee, Shubhadeep, Das, Shubasis, Mandal, Mahitosh, Perumal, Venkatesan, Sen, R. K.   +4 more
core   +1 more source

Celecoxib cocrystal polymorphs† [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Celecoxib (CEL) is a well-known nonsteroidal anti-inflammatory drug (NSAID) and selectively used from the cocxib family. It is a specific COX-2 inhibitor for pain and inflammation without inhibiting COX-1. A major downside of this popular NSAID is its poor aqueous solubility (9 mg L–1), which limits bioavailability (40%). Several methods were attempted
Ashwini Nangia, Sudhir Mittapalli, Geetha Bolla   +2 more
openaire   +2 more sources

Preassembly‐Controlled Radical Recombination at Bismuth: Decarboxylative C─N Coupling with Sulfonamides

Chemistry – A European Journal, EarlyView.
Radical processes involving bismuth hold great potential, but innovative strategies are required to control the reactivity of bismuth intermediates. Herein, we report a direct photochemical decarboxylation with molecular bismuth for C─N coupling of benzylic carboxylic acids and sulfonamides.
Elina K. Taskinen, Dominik Birnthaler, Vid Kermelj, Burkhard König   +3 more
wiley   +1 more source

Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial.

Journal of Clinical Oncology, 2019
PURPOSE The overexpression of cyclooxygenase 2 (COX-2) gene, also known as prostaglandin-endoperoxide synthase 2 ( PTGS2), occurs in breast cancer, but whether it affects response to anticox drugs remains unclear.
A. Hamy, Sandrine Tury, Xiaofei Wang, Junheng Gao, J. Pierga, S. Giacchetti, E. Brain, B. Pistilli, M. Marty, M. Espié, G. Benchimol, E. Laas, M. Laé, B. Asselain, B. Aouchiche, M. Edelman, F. Reyal   +16 more
semanticscholar   +1 more source

Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy

ChemMedChem, EarlyView.
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg, Robert Schuster, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Jonas Schädlich, Markus Laube, Jens Pietzsch, Vuk Gordić, Tamara Krajnović, Sanja Mijatović, Danijela Maksimović‐Ivanić, Evamarie Hey‐Hawkins   +12 more
wiley   +1 more source

Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression

PLoS ONE, 2019
The current study aimed to identify the radiosensitizing effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy in non-small-cell lung cancer (NSCLC) cells. The combination of celecoxib potentiated radiation-
Pan Zhang, D. He, Erqun Song, Mingdong Jiang, Yang Song   +4 more
semanticscholar   +1 more source

Selective Cyclooxygenase-2 Inhibitor Prevents Cisplatin-induced Tumorigenesis in A/J Mice [PDF]

, 2012
Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX-2) inhibitors have been shown to prevent carcinogen-induced experimental tumors. We investigated the effect of a COX-2 inhibitor, celecoxib, on cisplatin-
Katayama, Hideki, Kishino, Daizo, Kiura, Katsuyuki, Kuyama, Shouichi, Mimoto, Junko, Okada, Toshiaki, Sato, Ken, Takigawa, Nagio, Tanimoto, Mitsune, Ueoka, Hiroshi   +9 more
core   +1 more source

Carborane‐Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index

ChemMedChem, EarlyView.
Eight nido‐ and ortho‐carborane compounds based on celecoxib and flurbiprofen were synthesized and their COX inhibition was determined. The deboronation of the di‐substituted celecoxib derivative results in a switch from COX‐1 inhibitory preference to COX‐2 inhibition.
Lea Ueberham, Jonas Schädlich, Kim Schramke, Sebastian Braun, Christoph Selg, Markus Laube, Peter Lönnecke, Jens Pietzsch, Evamarie Hey‐Hawkins   +8 more
wiley   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source

Celecoxib Inhibits Hepatocellular Carcinoma Cell Growth and Migration by Targeting PNO1

Medical Science Monitor, 2019
Background Celecoxib has shown anti-tumor activities against several types of cancer. Although the majority of research focuses on its mechanism via cyclooxygenase-2 (COX-2) enzyme inhibition, we identified a distinct mechanism behind celecoxib anti ...
Huijun Dai, Suisui Zhang, Riliang Ma, Linghui Pan   +3 more
semanticscholar   +1 more source