Results 211 to 220 of about 10,389,331 (239)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Toward generalizable prediction of cancer signal using a cell-free DNA language model. [PDF]

Cell Rep Med
Xu Y, Bao H, Huang D, Zhang K, Zhu J, Yang L, Fu S, Chang Z, Zhang J, Chang S, Zhu B, Wu S, Yang S, Wu X, Shao Y.   +14 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Using cell-free DNA tumor methylation score to detect and monitor cholangiocarcinoma. [PDF]

HPB (Oxford)
Javanshir S, Angeli-Pahim I, Iyengar P, Chambers A, Smarandache IM, Ganguli R, Shrestha A, Squadrito J, Abreu A, Suchan G, Rizk C, Palaz F, Hughes SJ, Sahin I, Grajo JR, Duarte S, Zarrinpar A.   +16 more
europepmc   +1 more source

<i>GastroAlert</i>: a multimodal epigenetic blood test for early detection of gastric cancer using cell-free DNA. [PDF]

Mil Med Res
Xu YJ, Xu JF, Xia CF, Wu YJ, Li DG, Liu TY, Cui HP, Zhang J, Shang L, Chen WQ.   +9 more
europepmc   +1 more source

Prognostic Significance of Cell-Free DNA Derived 5-Hydroxymethylcytosine Signatures in Newly Diagnosed Multiple Myeloma. [PDF]

JCO Precis Oncol
Zhang Z, Derman B, Wang B, Kowitwanich K, Cursio J, Gao L, Appelbaum D, He C, Jakubowiak A, Zhang W, Chiu BC.   +10 more
europepmc   +1 more source

The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities. [PDF]

Front Immunol
Jones E, Cano-Gamez K.
europepmc   +1 more source

Donor-derived cell-free DNA testing for noninvasive monitoring of allograft rejection after lung transplantation. [PDF]

Front Immunol
Ding S, Sun Y, Zheng X, Mai S, Wu J, Xu Y, Chen J, Huang M.   +7 more
europepmc   +1 more source

Preoperative Plasma Cell-Free DNA Integrity Index in Clear Cell Renal Cell Carcinoma: An Exploratory Case-Control Study. [PDF]

Cancers (Basel)
Milecki T, Stępka J, Wesoły J, Cieślikowski WA.   +3 more
europepmc   +1 more source

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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Heather Parsons, Atish D. Choudhury, Michael L Cheng   +2 more
exaly