Results 81 to 90 of about 10,920,537 (245)

Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]

, 2010
The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core   +1 more source

Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield.

PLoS ONE, 2011
ObjectiveCell-free fetal DNA is a source of fetal genetic material that can be used for non-invasive prenatal diagnosis. Usually constituting less than 10% of the total cell free DNA in maternal plasma, the majority is maternal in origin.
Angela N Barrett, Bernhard G Zimmermann, Darrell Wang, Andrew Holloway, Lyn S Chitty   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Cell-free DNA promotes malignant transformation in non-tumor cells

Scientific Reports, 2020
Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-
Aline Gomes de Souza, Victor Alexandre F. Bastos, Patricia Tieme Fujimura, Izabella Cristina C. Ferreira, Letícia Ferro Leal, Luciane Sussuchi da Silva, Ana Carolina Laus, Rui Manuel Reis, Mario Machado Martins, Paula Souza Santos, Natássia C. Resende Corrêa, Karina Marangoni, Carolina Hassibe Thomé, Leandro Machado Colli, Luiz Ricardo Goulart, Vivian Alonso Goulart   +15 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes [PDF]

, 2011
We report a novel optical biosensor platform using near-infrared fluorescent single-walled carbon nanotubes (SWNTs) functionalized with target-recognizing aptamer DNA for noninvasively detecting cell-signaling molecules In real time.
Rickus, Jenna, Jong Hyun Choi, Choi, Jong Hyun, Sauffer, M. Dane, Benjamin A. Baker, Salgado, Janette, Jaroch, David, Janette Salgado, D. Marshall Porterfield, M. Dane Sauffer, David Jaroch, Jenna L. Rickus, Cha, Tae-Gon, Tae-Gon Cha, Baker, Benjamin A., Porterfield, D. Marshall, Janette Salgado (2041291), David Jaroch (2198059), Jenna L. Rickus (2198056), Benjamin A. Baker (2041294), Jong Hyun Choi (1425256), Tae-Gon Cha (1666642), D. Marshall Porterfield (2151688), M. Dane Sauffer (2198062)   +23 more
core   +1 more source

Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma

npj Precision Oncology
Glioblastoma is the most common and deadly brain cancer in adults. Although the disease disrupts the blood-brain barrier and exposes the tumor to the systemic circulation, using circulating cell-free DNA as a non-invasive biomarker for diagnosing ...
Hunter R. Underhill, Drew L. Sellers, Sabine Hellwig, Hediyeh Baradaran, Mary P. Bronner, Alun Thomas, Sarah Menacho, Christian J. Davidson, Rachna Malani, Andrew Farrell, Michael Karsy, David A. Nix, Yingqi Zhang, Laura A. Boatz, Joe Mendez, Lindsay Burt, Donald Cannon, Charlie S. Dean, Brion E. Harrison, Samuel Stevenson, Kinga Aitken, Stefan M. Pulst, Howard Colman, Randy L. Jensen   +23 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The ROC curves of cell-free fetal DNA and cell-free total DNA levels in total spontaneous abortion.

, 2013
The ROC curves of cell-free fetal DNA and cell-free total DNA levels are represented by red and blue lines, respectively.
You Jung Han (195038), Min Hyoung Kim (283284), Hyun Mee Ryu (195047), So Yeon Park (195028), Moon Young Kim (195043), Ji Hyae Lim (195020), Da Eun Lee (283285), Jung Yeol Han (283286)   +7 more
core   +1 more source