Results 161 to 170 of about 10,358,430 (239)

TP53 mutations on circulating cell-free DNA

EBioMedicine, 2016
Klaus Pantel
doaj   +1 more source

Cell-free DNA genomic and fragmentomic features for early outcome prediction in large B cell lymphoma. [PDF]

Cell Rep Med
Wang S, Mapar P, Moldovan N, van der Pol Y, Safrastyan A, van Werkhoven E, Tantyo NA, Snieder B, Do Brito Valente AF, de Jonge AV, Dinmohamed A, Drees EEE, Roemer MGM, Ylstra B, Klerk CPW, Strobbe L, Sandberg Y, Boersma RS, Koene H, Pruijt H, de Heer K, van Rijn R, Bilgin YM, de Jongh E, Nijland M, van der Poel M, Koster A, Nieuwenhuizen L, Fijnheer R, Beeker A, Mous R, Vergote VKJ, Vermaat JSP, Pegtel DM, Chamuleau MED, Mouliere F.   +35 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Circulating cell-free DNA in hematological malignancies

Haematologica, 2016
Lieselot Buedts, Peter Vandenberghe
doaj   +1 more source

Validation of the TransplantTrace cfDNA Kidney assay for measurement of donor-derived cell-free DNA in transplant recipients. [PDF]

Front Med (Lausanne)
Berg M, VanBemmel K, Klustner S, Westerling S, Pettersson L, Foord E, Kalista T, Uhlin M.   +7 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Detection of recurrence of HPV-driven oropharyngeal cancer by HPV cell-free DNA. [PDF]

Sci Rep
Fricke NM, Guarda V, Höfler D, Waterboer T, Schouten CS, Ikenberg K, Schroeder L, Rosing F, Broglie Daeppen MA.   +8 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Impact of preanalytical variables on urinary cell-free DNA quality: Centrifugation, EDTA concentration, storage and thawing strategies. [PDF]

PLoS One
Li W, Guo S, Zhou Z, Peng H, Fu Y, Zou C, Zhang X, Li S, Zhou Z, Qian K, Zhang S.   +10 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source